FOXP3 and FOSB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FOXP3	FOSB
Description		forkhead box P3	FosB proto-oncogene, AP-1 transcription factor subunit
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex	Chromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Histone Acetyltransferase Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding NF-kappaB Binding NFAT Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II B Cell Homeostasis Negative Regulation Of Cytokine Production Myeloid Cell Homeostasis CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Lineage Commitment T Cell Mediated Immunity Tolerance Induction Tolerance Induction To Self Antigen T Cell Tolerance Induction Regulation Of Immunoglobulin Production Positive Regulation Of T Cell Tolerance Induction Regulation Of T Cell Anergy Positive Regulation Of T Cell Anergy Negative Regulation Of Chronic Inflammatory Response Negative Regulation Of T Cell Cytokine Production Positive Regulation Of Peripheral T Cell Tolerance Induction T Cell Anergy Chromatin Remodeling DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Inflammatory Response Negative Regulation Of Cell Population Proliferation Response To Virus Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Establishment Of Endothelial Blood-brain Barrier Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Lipopolysaccharide Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-4 Production Negative Regulation Of Interleukin-5 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-4 Production Negative Regulation Of CREB Transcription Factor Activity Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Transforming Growth Factor Beta1 Production Positive Regulation Of Transforming Growth Factor Beta1 Production Immature T Cell Proliferation In Thymus Positive Regulation Of Immature T Cell Proliferation In Thymus CD4-positive, Alpha-beta T Cell Proliferation T Cell Proliferation T Cell Activation Negative Regulation Of T Cell Proliferation T Cell Homeostasis CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Negative Regulation Of DNA-binding Transcription Factor Activity Regulatory T Cell Differentiation Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Activated T Cell Proliferation Alpha-beta T Cell Proliferation Negative Regulation Of Alpha-beta T Cell Proliferation Lymphocyte Proliferation Isotype Switching To IgE Isotypes Negative Regulation Of Isotype Switching To IgE Isotypes Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Defense Response To Virus Negative Regulation Of Inflammatory Response Negative Regulation Of Immune Response T Cell Receptor Signaling Pathway Response To Rapamycin Negative Regulation Of T-helper 17 Cell Differentiation Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation	Negative Regulation Of Transcription By RNA Polymerase II Response To Amphetamine Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Female Pregnancy Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Progesterone Cellular Response To Hormone Stimulus Response To Nicotine Response To Cocaine Response To Morphine Response To Ethanol Positive Regulation Of Transcription By RNA Polymerase II Behavioral Response To Cocaine Response To Corticosterone Response To CAMP Cellular Response To Calcium Ion
Pathways		RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) RUNX1 regulates transcription of genes involved in WNT signaling	Estrogen-dependent gene expression NGF-stimulated transcription NGF-stimulated transcription Regulation of PD-L1(CD274) transcription
Drugs
Diseases		Permanent neonatal diabetes mellitus (PNDM) Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS		Vitiligo ( 27723757)	Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Heel bone mineral density ( 28869591 30598549)
Interacting Genes		18 interacting genes: EP300 FOSB IKZF4 KAT8 KRTAP3-3 KRTAP6-2 KRTAP8-1 MDM2 NFAT5 NFATC2 NLK PRR20A PRR20B PRR20C PRR20D PRR20E RBPMS RUNX1	28 interacting genes: AGXT CENPO CREB5 CYTH4 DNMT3L ENKD1 EP300 FAM222B FAM90A1 FOXP3 GLIS2 JUNB JUND LINC00963 NCK2 NEDD9 NFE2L2 PHC2 PHF1 POGZ POU6F2 ROR2 SRA1 TENT5B TLE5 TLX3 VEZF1 ZC3H10
Entrez ID		50943	2354
HPRD ID		02242	01270
Ensembl ID		ENSG00000049768	ENSG00000125740
Uniprot IDs		Q9BZS1	P53539
PDB IDs		3QRF 4WK8	5VPA 5VPB 5VPC 5VPD 5VPE 5VPF 6UCI 6UCL 6UCM 7UCC 7UCD
Enriched GO Terms of Interacting Partners?		Protein Propionyltransferase Activity DNA-binding Transcription Factor Binding Pre-mRNA Intronic Binding Histone H4 Acetyltransferase Activity Negative Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Acetyltransferase Activity Transcription By RNA Polymerase II Calcineurin-NFAT Signaling Cascade Positive Regulation Of RNA Metabolic Process Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity Negative Regulation Of RNA Metabolic Process Calcineurin-mediated Signaling Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Macromolecule Biosynthetic Process Histone Acetyltransferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Intermediate Filament Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Hemopoiesis DNA-templated Transcription Positive Regulation Of Receptor Signaling Pathway Via STAT Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Response To Cocaine Response To Formaldehyde Cellular Response To Vitamin B1 Positive Regulation Of Gene Expression Cellular Response To Osmotic Stress Transcription Coactivator Binding Transcription Initiation-coupled Chromatin Remodeling Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Protein Processing Positive Regulation Of Alpha-beta T Cell Differentiation	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Chromatin Regulation Of T-helper 17 Type Immune Response Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Factor AP-1 Complex Transcription Coregulator Binding Protein-DNA Complex DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Metabolic Process Regulation Of T-helper Cell Differentiation DNA-binding Transcription Factor Activity Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Negative Regulation Of RNA Metabolic Process ESC/E(Z) Complex Sequence-specific Double-stranded DNA Binding Regulation Of CD4-positive, Alpha-beta T Cell Activation Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Activation CD4-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Cell Differentiation Zinc Ion Binding Alpha-beta T Cell Lineage Commitment CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Alpha-beta T Cell Activation Negative Regulation Of Macromolecule Metabolic Process L-serine-pyruvate Transaminase Activity T Cell Lineage Commitment
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