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TRAT1 and CD247
Number of citations of the paper that reports this interaction (PMID
9687533
)
22
Data Source:
HPRD
(in vivo)
TRAT1
CD247
Gene Name
T cell receptor associated transmembrane adaptor 1
CD247 molecule
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
T Cell Receptor Complex
Cytoplasm
Plasma Membrane
Integral Component Of Membrane
T Cell Receptor Complex
Alpha-beta T Cell Receptor Complex
Molecular Function
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Transmembrane Signaling Receptor Activity
Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Biological Process
Negative Regulation Of Receptor Recycling
Cellular Defense Response
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Innate Immune Response
Neurotrophin TRK Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Positive Regulation Of Calcium-mediated Signaling
T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Receptor Signaling Pathway
Negative Regulation Of Transport
Viral Process
T Cell Costimulation
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Innate Immune Response
Regulation Of Defense Response To Virus By Virus
Regulation Of Immune Response
T Cell Receptor Signaling Pathway
Pathways
Signaling by the B Cell Receptor (BCR)
Downstream TCR signaling
Signaling by FGFR in disease
PIP3 activates AKT signaling
Signaling by EGFRvIII in Cancer
Signaling by SCF-KIT
Downstream signaling events of B Cell Receptor (BCR)
DAP12 signaling
PI3K/AKT activation
PI-3K cascade
PI3K events in ERBB2 signaling
Downstream signaling of activated FGFR
Innate Immune System
Signaling by PDGF
Signalling by NGF
DAP12 interactions
GAB1 signalosome
Signaling by Ligand-Responsive EGFR Variants in Cancer
NGF signalling via TRKA from the plasma membrane
Signaling by ERBB4
Signaling by Overexpressed Wild-Type EGFR in Cancer
Role of LAT2/NTAL/LAB on calcium mobilization
Constitutive PI3K/AKT Signaling in Cancer
PI3K events in ERBB4 signaling
Signaling by FGFR
Signaling by ERBB2
Signaling by EGFR
TCR signaling
Downstream signal transduction
Fc epsilon receptor (FCERI) signaling
Signaling by EGFR in Cancer
PI3K/AKT Signaling in Cancer
Adaptive Immune System
Drugs
Diseases
GWAS
Celiac disease (
20190752
)
Celiac disease and Rheumatoid arthritis (
21383967
)
Rheumatoid arthritis (
20453842
)
Systemic sclerosis (
21750679
20383147
21779181
)
Protein-Protein Interactions
11 interactors:
CD247
CD3E
FYN
GRB2
LCK
LCP2
LYN
PIK3R1
SRC
TRA
TRB
38 interactors:
CD2
CD244
CD28
CD3D
CD48
CD5
CSK
DOCK2
FCGR3A
FYN
GAB2
GRB2
JAK3
LCK
LY6E
NCR1
NCR3
PCGF2
PI4K2B
PTPN22
PTPN3
PTPN6
PTPRC
SH2B3
SHC1
SLA
SLA2
STAT5A
STAT5B
TFRC
TIRAP
TRA
TRAT1
TRB
UNC119
VTN
ZAP70
ZNF281
Entrez ID
50852
919
HPRD ID
05392
01729
Ensembl ID
ENSG00000163519
ENSG00000198821
Uniprot IDs
Q6PIZ9
P20963
PDB IDs
1TCE
1YGR
2HAC
2OQ1
3IK5
3IOZ
Enriched GO Terms of Interacting Partners
?
T Cell Costimulation
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of T Cell Activation
Positive Regulation Of Homotypic Cell-cell Adhesion
Immune Response-regulating Signaling Pathway
Positive Regulation Of Cell-cell Adhesion
Fc Receptor Signaling Pathway
Regulation Of T Cell Activation
Positive Regulation Of Cell Activation
Antigen Receptor-mediated Signaling Pathway
Positive Regulation Of Immune Response
Regulation Of Cell-cell Adhesion
Positive Regulation Of Cell Adhesion
Regulation Of Lymphocyte Activation
Platelet Activation
Regulation Of Immune Response
Positive Regulation Of Immune System Process
Regulation Of Cell Activation
T Cell Receptor Signaling Pathway
Regulation Of Cell Adhesion
Cell Activation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Immune System Process
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc Receptor Mediated Stimulatory Signaling Pathway
Fc-gamma Receptor Signaling Pathway
Innate Immune Response
Blood Coagulation
Hemostasis
Enzyme Linked Receptor Protein Signaling Pathway
Leukocyte Migration
Fc-epsilon Receptor Signaling Pathway
Viral Process
Phagocytosis
Regulation Of Body Fluid Levels
Wound Healing
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Peptide
Immune System Process
Response To Wounding
Immune Response
Peptidyl-tyrosine Autophosphorylation
Defense Response
Epidermal Growth Factor Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Response To Peptide Hormone
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Immune System Process
Regulation Of Immune System Process
Regulation Of Immune Response
Regulation Of Cell Activation
Positive Regulation Of Cell Activation
Regulation Of Lymphocyte Activation
Positive Regulation Of Immune System Process
Regulation Of T Cell Activation
Positive Regulation Of Immune Response
Cell Activation
Immune Response-regulating Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Cell-cell Adhesion
Positive Regulation Of T Cell Activation
Positive Regulation Of Homotypic Cell-cell Adhesion
Positive Regulation Of Cell-cell Adhesion
Antigen Receptor-mediated Signaling Pathway
Positive Regulation Of Cell Adhesion
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Cell Adhesion
Lymphocyte Activation
Homotypic Cell-cell Adhesion
Leukocyte Activation
T Cell Aggregation
T Cell Activation
Lymphocyte Aggregation
Leukocyte Aggregation
Hemopoiesis
Defense Response
Single Organismal Cell-cell Adhesion
Leukocyte Cell-cell Adhesion
Immune System Development
Leukocyte Differentiation
T Cell Receptor Signaling Pathway
T Cell Costimulation
Immune Response
T Cell Differentiation
Lymphocyte Differentiation
Innate Immune Response
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
T Cell Differentiation In Thymus
Positive Regulation Of Signal Transduction
Organ Development
Response To Stress
Response To Stimulus
Signal Transduction
Regulation Of Body Fluid Levels
Leukocyte Migration
Cell Adhesion
Positive Regulation Of Gamma-delta T Cell Differentiation
Tagcloud
?
already
annotation
annotations
autoimmunity
b6
cd3
characteristically
chip
coding
elements
encode
encodes
encyclopedia
enrich
gencode
intron
manual
marks
project
qrt
quantification
seq
spatially
supported
t1d
tcr
throughput
utilized
wealth
Tagcloud (Difference)
?
already
annotation
annotations
autoimmunity
b6
cd3
characteristically
chip
coding
elements
encode
encodes
encyclopedia
enrich
gencode
intron
manual
marks
project
qrt
quantification
seq
spatially
supported
t1d
tcr
throughput
utilized
wealth
Tagcloud (Intersection)
?