TRAT1 and CD3E

Number of citations of the paper that reports this interaction (PubMedID 9687533)
35

Data Source:
HPRD (in vivo)

		TRAT1	CD3E
Description		T cell receptor associated transmembrane adaptor 1	CD3 epsilon subunit of T-cell receptor complex
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Centriolar Satellite T Cell Receptor Complex Mitotic Spindle	Immunological Synapse Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex Gamma-delta T Cell Receptor Complex Dendritic Spine Cell Body
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding SH3 Domain Binding Protein Kinase Binding Signaling Receptor Complex Adaptor Activity T Cell Receptor Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Receptor Recycling Adaptive Immune Response Immune System Process Cellular Defense Response Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Transport	Positive Regulation Of Cell-matrix Adhesion Adaptive Immune Response Immune System Process Positive Regulation Of T Cell Anergy T Cell Anergy Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Signal Complex Assembly G Protein-coupled Receptor Signaling Pathway Smoothened Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Dendrite Development Calcium-mediated Signaling Cerebellum Development T Cell Costimulation Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Cell-cell Adhesion Mediated By Integrin CD4-positive, Alpha-beta T Cell Proliferation T Cell Proliferation Positive Regulation Of T Cell Proliferation T Cell Activation Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Thymic T Cell Selection Negative Thymic T Cell Selection Negative Regulation Of Smoothened Signaling Pathway Gamma-delta T Cell Activation Alpha-beta T Cell Activation Lymphocyte Activation Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Protein-containing Complex Assembly Apoptotic Signaling Pathway Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Pathways		PIP3 activates AKT signaling Downstream TCR signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules Co-inhibition by PD-1
Drugs			Muromonab Teplizumab Catumaxomab Mosunetuzumab Teclistamab Odronextamab
Diseases			T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS		Autoimmune thyroid disease ( 32581359)	Lung cancer in ever smokers ( 28604730) Pulse pressure ( 27841878)
Interacting Genes		13 interacting genes: BDKRB1 CD247 CD3E FYN GRB2 LCK LCP2 LYN PIK3R1 SEC22A SRC TRA TRB	26 interacting genes: ADAM33 BNIP3 CD3D CD3G CD79B CSK EPS8L1 LCK MUC15 NCK1 NCK2 NCL PIK3R1 PKMYT1 POLR1G PTPN22 SHC1 SNTA1 SYK TOP2B TRAT1 TRB UBASH3A UNC119 ZAP70 ZFPL1
Entrez ID		50852	916
HPRD ID		05392	08923
Ensembl ID		ENSG00000163519	ENSG00000198851
Uniprot IDs		C9JF66 Q6PIZ9	P07766
PDB IDs			1A81 1SY6 1XIW 2ROL 5QU2 6JXR 7FJD 7FJE 7FJF 7PHR 8ES7 8ES8 8ES9 8F0L 8JC0 8JCB 8TW4 8TW6 8VY4 8WXE 8WY0 8WYI 8YC0 9BBC 9C3E 9CI8 9CIA 9CQ4
Enriched GO Terms of Interacting Partners?		T Cell Costimulation Immune Response-activating Cell Surface Receptor Signaling Pathway Alpha-beta T Cell Receptor Complex Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Leukocyte Activation Fc-gamma Receptor Signaling Pathway Immune Response-activating Signaling Pathway Cell Activation Positive Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway T Cell Receptor Complex Immune System Process Regulation Of Immune Response Cell-cell Junction Ephrin Receptor Binding Enzyme-linked Receptor Protein Signaling Pathway Immune Effector Process Positive Regulation Of Immune Response Regulation Of Immune System Process T Cell Receptor Signaling Pathway Lymphocyte Activation Positive Regulation Of T Cell Activation Immune Response Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Leukocyte Cell-cell Adhesion Adaptive Immune Response T Cell Activation Peptidyl-tyrosine Phosphorylation Phospholipase Activator Activity T Cell Receptor Binding Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Cell Surface Receptor Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Phosphatidylinositol 3-kinase Binding Leukocyte Mediated Cytotoxicity Gamma-delta T Cell Activation Stimulatory C-type Lectin Receptor Signaling Pathway Phospholipase Binding Cellular Response To Lectin Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Leukocyte Migration Detection Of Tumor Cell Regulation Of Cell Adhesion	Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Receptor Complex Lymphocyte Activation Phosphotyrosine Residue Binding Regulation Of T Cell Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Receptor Signaling Pathway Leukocyte Activation Regulation Of Immune Response T Cell Activation Cell Activation Immune Response-activating Signaling Pathway Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Adaptive Immune Response Positive Regulation Of Immune System Process Regulation Of Immune System Process Positive Regulation Of Immune Response Lymphocyte Differentiation Alpha-beta T Cell Receptor Complex T Cell Selection Negative Regulation Of T Cell Receptor Signaling Pathway Immune System Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Mononuclear Cell Differentiation Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Thymic T Cell Selection T Cell Receptor Binding Positive T Cell Selection Leukocyte Differentiation Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Gamma-delta T Cell Activation T Cell Differentiation Thymic T Cell Selection Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of MAPK Cascade Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Beta Selection Immune Response Regulation Of Cell-cell Adhesion B Cell Activation Positive Regulation Of Cell-cell Adhesion
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