TRAT1

Name	T cell receptor associated transmembrane adaptor 1
Structure	No pdb structure
Interactors	13 interactors: BDKRB1 CD247 CD3E FYN GRB2 LCK LCP2 LYN PIK3R1 SEC22A SRC TRA TRB
GO Annotations	Cellular Component	Plasma Membrane Membrane Centriolar Satellite T Cell Receptor Complex Mitotic Spindle
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding
	Biological Process	Negative Regulation Of Receptor Recycling Adaptive Immune Response Immune System Process Cellular Defense Response Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Transport
Pathways	PIP3 activates AKT signaling Downstream TCR signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
GWAS	Autoimmune thyroid disease ( 32581359 )
Entrez ID	50852
HPRD ID	05392
Ensembl ID	ENSG00000163519
Uniprot IDs	C9JF66 Q6PIZ9
PDB IDs	Not available
GO Terms Enriched among Interactors ?	T Cell Costimulation Immune Response-activating Cell Surface Receptor Signaling Pathway Alpha-beta T Cell Receptor Complex Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Leukocyte Activation Fc-gamma Receptor Signaling Pathway Immune Response-activating Signaling Pathway Cell Activation Positive Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway T Cell Receptor Complex Immune System Process Regulation Of Immune Response Cell-cell Junction Ephrin Receptor Binding Enzyme-linked Receptor Protein Signaling Pathway Immune Effector Process Positive Regulation Of Immune Response Regulation Of Immune System Process T Cell Receptor Signaling Pathway Lymphocyte Activation Positive Regulation Of T Cell Activation Immune Response Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Leukocyte Cell-cell Adhesion Adaptive Immune Response T Cell Activation Peptidyl-tyrosine Phosphorylation Phospholipase Activator Activity T Cell Receptor Binding Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Cell Surface Receptor Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Phosphatidylinositol 3-kinase Binding Leukocyte Mediated Cytotoxicity Gamma-delta T Cell Activation Stimulatory C-type Lectin Receptor Signaling Pathway Phospholipase Binding Cellular Response To Lectin Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Leukocyte Migration Detection Of Tumor Cell Regulation Of Cell Adhesion