CPEB2 and USP42

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		CPEB2	USP42
Description		cytoplasmic polyadenylation element binding protein 2	ubiquitin specific peptidase 42
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Neuron Projection Synapse	Nucleus Nucleoplasm Cytosol
	Molecular Function	MRNA Regulatory Element Binding Translation Repressor Activity Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding GTPase Inhibitor Activity Translation Factor Activity, RNA Binding MRNA 3'-UTR AU-rich Region Binding Ribosome Binding Ribosomal Large Subunit Binding Ribosomal Small Subunit Binding Translation Regulator Activity	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Translation Regulation Of Translation Cellular Response To Insulin Stimulus Cellular Response To Hypoxia Negative Regulation Of Cytoplasmic Translational Elongation Negative Regulation Of Cytoplasmic Translation	Proteolysis Spermatogenesis Protein Deubiquitination Cell Differentiation Regulation Of Protein Stability Regulation Of Apoptotic Process
Pathways			Ub-specific processing proteases
Drugs
Diseases
GWAS		Cognitive flexibility ( 30134085) Triglyceride levels ( 32203549) Type 2 diabetes ( 33479058)	Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321)
Interacting Genes		26 interacting genes: ATG2A ATP1B2 BSCL2 C2CD2L CAPN15 COPS7A DMRTB1 ERI3 GAA GABBR1 GPX7 KEAP1 MT-ATP6 NECAB2 OTUB1 PIGS PSAP PUF60 RBPMS SEMA4B SORBS3 SPARC TFIP11 TUBA1A U2AF1 USP42	6 interacting genes: CPEB2 HRAS RNF10 SPP1 TP53 UBC
Entrez ID		132864	84132
HPRD ID		16744	18879
Ensembl ID		ENSG00000137449	ENSG00000106346
Uniprot IDs		A0A5K1VW61 A0A5K1VW71 A0A5K1VW79 A0A5K1VW93 Q7Z5Q1	Q9H9J4
PDB IDs
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Nervous System Development Negative Regulation Of Neurogenesis Negative Regulation Of Glial Cell Proliferation Cellular Response To Gamma Radiation Fibroblast Proliferation Negative Regulation Of Cell Development Negative Regulation Of Gliogenesis Regulation Of Glial Cell Proliferation Response To Gamma Radiation Positive Regulation Of MiRNA Metabolic Process Cellular Response To Ionizing Radiation Cellular Senescence Ras Protein Signal Transduction Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Regulation Of Neurogenesis Regulation Of Tissue Remodeling Regulation Of Nervous System Development Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Negative Regulation Of Cytoplasmic Translational Elongation Regulation Of MiRNA Metabolic Process Regulation Of Fibroblast Proliferation Regulation Of Gliogenesis Phospholipase C Activator Activity Neuron Apoptotic Process Response To Ionizing Radiation GTPase Complex Positive Regulation Of Estradiol Secretion Regulation Of Estradiol Secretion Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Negative Regulation Of Pentose-phosphate Shunt Cellular Response To Decreased Oxygen Levels Oxidative Stress-induced Premature Senescence Cellular Response To Hypoxia Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Glucose Catabolic Process To Lactate Via Pyruvate MRNA 3'-UTR Binding Germ Cell Nucleus Cellular Response To Actinomycin D Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Cell Differentiation Negative Regulation Of Cell Population Proliferation Tissue Development Regulation Of Response To Wounding Cellular Response To Radiation Intrinsic Apoptotic Signaling Pathway Positive Regulation Of RNA Metabolic Process
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