CPEB2 and ATP1B2

Number of citations: 54 (PubMedID 22157746)
Data Source: BioGRID (two hybrid)

		CPEB2	ATP1B2
Name		cytoplasmic polyadenylation element binding protein 2	ATPase Na+/K+ transporting subunit beta 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Neuron Projection Synapse	Photoreceptor Inner Segment Cytoplasm Plasma Membrane Sodium:potassium-exchanging ATPase Complex External Side Of Plasma Membrane Membrane Apical Plasma Membrane Lateral Plasma Membrane Cell Projection Membrane Cell Body Membrane Cell Periphery Astrocyte Projection Astrocyte End-foot Neuron To Neuron Synapse
	Molecular Function	MRNA Regulatory Element Binding Translation Repressor Activity Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding GTPase Inhibitor Activity Translation Factor Activity, RNA Binding MRNA 3'-UTR AU-rich Region Binding Ribosome Binding Ribosomal Large Subunit Binding Ribosomal Small Subunit Binding Translation Regulator Activity	ATPase Activator Activity Protein Binding Protein-macromolecule Adaptor Activity Protein Heterodimerization Activity ATPase Binding Transporter Activator Activity
	Biological Process	Translation Regulation Of Translation Cellular Response To Insulin Stimulus Cellular Response To Hypoxia Negative Regulation Of Cytoplasmic Translational Elongation Negative Regulation Of Cytoplasmic Translation	Retina Homeostasis Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Cell Adhesion Positive Regulation Of Neuron Projection Development Lateral Ventricle Development Third Ventricle Development Neuronal-glial Interaction Involved In Hindbrain Glial-mediated Radial Cell Migration Intracellular Potassium Ion Homeostasis Cell-substrate Adhesion Sodium Ion Export Across Plasma Membrane Photoreceptor Cell Maintenance Protein Stabilization Motor Behavior Membrane Repolarization Cell Communication By Electrical Coupling Involved In Cardiac Conduction Plasma Membrane Bounded Cell Projection Organization Transport Across Blood-brain Barrier Positive Regulation Of Sodium Ion Export Across Plasma Membrane Positive Regulation Of Potassium Ion Import Across Plasma Membrane Negative Regulation Of Glial Cell Migration Potassium Ion Import Across Plasma Membrane
Pathways		None	Basigin interactions Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs		None	Bisacodyl Tegoprazan
GWAS		Cognitive flexibility ( 30134085 ) Triglyceride levels ( 32203549 ) Type 2 diabetes ( 33479058 )	Brain morphology (MOSTest) ( 32665545 ) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Esophageal squamous cell carcinoma ( 25129146 ) Platelet count ( 32888494 ) Red cell distribution width ( 32888494 ) Refractive error ( 32231278 ) Sex hormone-binding globulin levels ( 22675492 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Type 2 diabetes (adjusted for BMI) ( 30297969 ) Waist circumference adjusted for body mass index ( 34021172 )
Novel Interactors		1 novel interactors: CC2D2A	None recorded
Interacting Genes		26 interacting genes: ATG2A ATP1B2 BSCL2 C2CD2L CAPN15 COPS7A DMRTB1 ERI3 GAA GABBR1 GPX7 KEAP1 MT-ATP6 NECAB2 OTUB1 PIGS PSAP PUF60 RBPMS SEMA4B SORBS3 SPARC TFIP11 TUBA1A U2AF1 USP42	2 interacting genes: CPEB2 NGB
Entrez ID		132864	482
HPRD ID		16744	01664
Ensembl ID		ENSG00000137449	ENSG00000129244
Uniprot IDs		A0A5K1VW61 A0A5K1VW71 A0A5K1VW79 A0A5K1VW93 Q7Z5Q1	P14415
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		None	Cellular Response To Oxygen Levels Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Negative Regulation Of Cytoplasmic Translational Elongation Response To Decreased Oxygen Levels Response To Oxygen Levels Response To Hypoxia Nitrite Reductase Activity Negative Regulation Of Translational Elongation Negative Regulation Of Cytoplasmic Translation Regulation Of Translational Elongation GTPase Inhibitor Activity Oxygen Carrier Activity Ribosomal Large Subunit Binding GDP-dissociation Inhibitor Activity MRNA Regulatory Element Binding Translation Repressor Activity Oxygen Transport Translation Regulator Activity Translation Factor Activity, RNA Binding Ribosomal Small Subunit Binding Oxygen Binding MRNA 3'-UTR AU-rich Region Binding Regulation Of Cytoplasmic Translation Cellular Response To Stress Ribosome Binding Cellular Response To Insulin Stimulus Heme Binding MRNA 3'-UTR Binding