CPEB2 and GAA

Number of citations of the paper that reports this interaction (PubMedID 22157746)
54

Data Source:
BioGRID (two hybrid)

		CPEB2	GAA
Description		cytoplasmic polyadenylation element binding protein 2	alpha glucosidase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Neuron Projection Synapse	Lysosome Lysosomal Membrane Plasma Membrane Membrane Azurophil Granule Membrane Lysosomal Lumen Extracellular Exosome Tertiary Granule Membrane Ficolin-1-rich Granule Membrane Autolysosome Lumen
	Molecular Function	MRNA Regulatory Element Binding Translation Repressor Activity Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding GTPase Inhibitor Activity Translation Factor Activity, RNA Binding MRNA 3'-UTR AU-rich Region Binding Ribosome Binding Ribosomal Large Subunit Binding Ribosomal Small Subunit Binding Translation Regulator Activity	Catalytic Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Alpha-1,4-glucosidase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Carbohydrate Binding Alpha-glucosidase Activity
	Biological Process	Translation Regulation Of Translation Cellular Response To Insulin Stimulus Cellular Response To Hypoxia Negative Regulation Of Cytoplasmic Translational Elongation Negative Regulation Of Cytoplasmic Translation	Maltose Metabolic Process Regulation Of The Force Of Heart Contraction Diaphragm Contraction Heart Morphogenesis Carbohydrate Metabolic Process Glycogen Metabolic Process Glycogen Catabolic Process Disaccharide Metabolic Process Sucrose Metabolic Process Glucose Metabolic Process Striated Muscle Contraction Lysosome Organization Locomotory Behavior Tissue Development Aorta Development Vacuolar Sequestering Muscle Cell Cellular Homeostasis Neuromuscular Process Controlling Posture Neuromuscular Process Controlling Balance Cardiac Muscle Contraction Glycophagy
Pathways			Glycogen storage disease type II (GAA) Neutrophil degranulation Glycogen breakdown (glycogenolysis)
Drugs			Acarbose Miglitol AT2220 alpha-Arbutin
Diseases			Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS		Cognitive flexibility ( 30134085) Triglyceride levels ( 32203549) Type 2 diabetes ( 33479058)	Blood protein levels ( 30072576) Platelet distribution width ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		26 interacting genes: ATG2A ATP1B2 BSCL2 C2CD2L CAPN15 COPS7A DMRTB1 ERI3 GAA GABBR1 GPX7 KEAP1 MT-ATP6 NECAB2 OTUB1 PIGS PSAP PUF60 RBPMS SEMA4B SORBS3 SPARC TFIP11 TUBA1A U2AF1 USP42	11 interacting genes: CPEB2 CREBBP DYNC1LI2 EP300 HIVEP1 NCF1 NUMBL PARD3B RAB2A SH3GLB2 STAT2
Entrez ID		132864	2548
HPRD ID		16744	06006
Ensembl ID		ENSG00000137449	ENSG00000171298
Uniprot IDs		A0A5K1VW61 A0A5K1VW71 A0A5K1VW79 A0A5K1VW93 Q7Z5Q1	P10253
PDB IDs			5KZW 5KZX 5NN3 5NN4 5NN5 5NN6 5NN8 7P2Z 7P32
Enriched GO Terms of Interacting Partners?			Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Histone H3K27 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Acetylation N-terminal Protein Amino Acid Acetylation Regulation Of Cellular Response To Heat Acetyltransferase Activity Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity Regulation Of Innate Immune Response Protein Acetylation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Histone Acetyltransferase Activity Centrosome Localization Tau Protein Binding Transcription Coactivator Binding Protein Destabilization Canonical NF-kappaB Signal Transduction Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Negative Regulation Of Cytoplasmic Translational Elongation Damaged DNA Binding Response To Hypoxia Cell Surface Receptor Signaling Pathway Via JAK-STAT Cytoplasm P53 Binding Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Response To Decreased Oxygen Levels Response To Oxygen Levels Histone H2B Acetyltransferase Activity Cell Surface Receptor Signaling Pathway Via STAT Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Peptide Crotonyltransferase Activity Neutrophil-mediated Killing Of Fungus Chromatin DNA Binding Regulation Of Defense Response Cellular Response To UV Positive Regulation Of Protein Localization To Nucleus
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