CPEB2 and ERI3

Number of citations of the paper that reports this interaction (PubMedID 22157746)
54

Data Source:
BioGRID (two hybrid)

		CPEB2	ERI3
Description		cytoplasmic polyadenylation element binding protein 2	ERI1 exoribonuclease family member 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Neuron Projection Synapse
	Molecular Function	MRNA Regulatory Element Binding Translation Repressor Activity Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding GTPase Inhibitor Activity Translation Factor Activity, RNA Binding MRNA 3'-UTR AU-rich Region Binding Ribosome Binding Ribosomal Large Subunit Binding Ribosomal Small Subunit Binding Translation Regulator Activity	3'-5'-RNA Exonuclease Activity Nucleic Acid Binding RNA Binding Nuclease Activity Exonuclease Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Translation Regulation Of Translation Cellular Response To Insulin Stimulus Cellular Response To Hypoxia Negative Regulation Of Cytoplasmic Translational Elongation Negative Regulation Of Cytoplasmic Translation
Pathways
Drugs
Diseases
GWAS		Cognitive flexibility ( 30134085) Triglyceride levels ( 32203549) Type 2 diabetes ( 33479058)	Anxiety ( 33859377) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444)
Interacting Genes		26 interacting genes: ATG2A ATP1B2 BSCL2 C2CD2L CAPN15 COPS7A DMRTB1 ERI3 GAA GABBR1 GPX7 KEAP1 MT-ATP6 NECAB2 OTUB1 PIGS PSAP PUF60 RBPMS SEMA4B SORBS3 SPARC TFIP11 TUBA1A U2AF1 USP42	6 interacting genes: CENPO CPEB2 FNDC3B PRNP SHANK3 YTHDF1
Entrez ID		132864	79033
HPRD ID		16744	15175
Ensembl ID		ENSG00000137449	ENSG00000117419
Uniprot IDs		A0A5K1VW61 A0A5K1VW71 A0A5K1VW79 A0A5K1VW93 Q7Z5Q1	B4DEX5 B4DN03 O43414
PDB IDs			2XRI 7K05 7K06 7K07 7LPY 7LPZ 7LQ0
Enriched GO Terms of Interacting Partners?			Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Glutamate Receptor Signaling Pathway Memory Regulation Of Synaptic Plasticity Dendritic Spine Organization Learning Or Memory Neuron Projection Organization Postsynapse Organization Cognition Type 8 Metabotropic Glutamate Receptor Binding Ribosome Binding Mis6-Sim4 Complex Negative Regulation Of Cytoplasmic Translational Elongation Modulation Of Chemical Synaptic Transmission Guanylate Kinase-associated Protein Clustering Cellular Component Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Postsynapse Organization Negative Regulation Of Dendritic Spine Maintenance Cupric Ion Binding Regulation Of Cell Projection Organization Type 5 Metabotropic Glutamate Receptor Binding FHF Complex Learning Centromere Complex Assembly Negative Regulation Of Cell Volume AMPA Glutamate Receptor Clustering Synaptic Receptor Adaptor Activity Positive Regulation Of Synapse Structural Plasticity NMDA Glutamate Receptor Clustering Striatal Medium Spiny Neuron Differentiation Negative Regulation Of Translational Elongation ATP-dependent Protein Binding Aspartic-type Endopeptidase Inhibitor Activity Manchette Assembly Postsynaptic Density Assembly Regulation Of Synapse Structural Plasticity Protein Localization To Perinuclear Region Of Cytoplasm Vocal Learning Neuron Spine Cuprous Ion Binding Positive Regulation Of Long-term Neuronal Synaptic Plasticity Observational Learning Negative Regulation Of Cytoplasmic Translation Postsynaptic Density Microtubule Binding Dendritic Spine Maintenance Nervous System Process Postsynaptic Specialization Assembly
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