CPEB2 and CAPN15

Number of citations of the paper that reports this interaction (PubMedID 22157746)
54

Data Source:
BioGRID (two hybrid)

		CPEB2	CAPN15
Description		cytoplasmic polyadenylation element binding protein 2	calpain 15
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Neuron Projection Synapse	Cytoplasm
	Molecular Function	MRNA Regulatory Element Binding Translation Repressor Activity Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding GTPase Inhibitor Activity Translation Factor Activity, RNA Binding MRNA 3'-UTR AU-rich Region Binding Ribosome Binding Ribosomal Large Subunit Binding Ribosomal Small Subunit Binding Translation Regulator Activity	Calcium-dependent Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Translation Regulation Of Translation Cellular Response To Insulin Stimulus Cellular Response To Hypoxia Negative Regulation Of Cytoplasmic Translational Elongation Negative Regulation Of Cytoplasmic Translation	Proteolysis
Pathways			Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Cognitive flexibility ( 30134085) Triglyceride levels ( 32203549) Type 2 diabetes ( 33479058)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		26 interacting genes: ATG2A ATP1B2 BSCL2 C2CD2L CAPN15 COPS7A DMRTB1 ERI3 GAA GABBR1 GPX7 KEAP1 MT-ATP6 NECAB2 OTUB1 PIGS PSAP PUF60 RBPMS SEMA4B SORBS3 SPARC TFIP11 TUBA1A U2AF1 USP42	7 interacting genes: CPEB2 DAZAP2 RNF216 RNF26 SOX4 TRAF2 UBC
Entrez ID		132864	6650
HPRD ID		16744	07220
Ensembl ID		ENSG00000137449	ENSG00000103326
Uniprot IDs		A0A5K1VW61 A0A5K1VW71 A0A5K1VW79 A0A5K1VW93 Q7Z5Q1	O75808
PDB IDs
Enriched GO Terms of Interacting Partners?			Mitogen-activated Protein Kinase Kinase Kinase Binding Post-translational Protein Modification Protein Polyubiquitination Ubiquitin Protein Ligase Binding Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin Protein Ligase Activity Regulation Of Defense Response To Virus Macromolecule Catabolic Process TORC2 Complex Disassembly Negative Regulation Of Cytoplasmic Translational Elongation TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Modification-dependent Protein Catabolic Process Regulation Of Type I Interferon Production Ascending Aorta Morphogenesis Pro-B Cell Differentiation Sphingolipid Binding IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex Atrial Septum Primum Morphogenesis Regulation Of Gene Expression Protein Modification Process CD27 Signaling Pathway Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Translational Elongation Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Noradrenergic Neuron Differentiation Tumor Necrosis Factor Binding Tumor Necrosis Factor Receptor Superfamily Binding Mitral Valve Morphogenesis Regulation Of Cytokine Production Protein Localization To Perinuclear Region Of Cytoplasm Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Gamma-delta T Cell Activation Cellular Response To Oxygen-containing Compound Regulation Of Gamma-delta T Cell Differentiation Thioesterase Binding CD40 Receptor Complex CD40 Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Interleukin-17-mediated Signaling Pathway Catabolic Process Negative Regulation Of Cytoplasmic Translation Regulation Of Translational Elongation Lymphoid Progenitor Cell Differentiation Positive Regulation Of JUN Kinase Activity
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