CDK11B and EIF3F

Number of citations of the paper that reports this interaction (PubMedID 36736316)
80

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		CDK11B	EIF3F
Description		cyclin dependent kinase 11B	eukaryotic translation initiation factor 3 subunit F
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GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Cytoplasm	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Synapse Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
	Molecular Function	Nucleotide Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Translation Initiation Factor Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Metallopeptidase Activity Hydrolase Activity Translation Initiation Factor Binding Identical Protein Binding Deubiquitinase Activity Metal-dependent Deubiquitinase Activity
	Biological Process	Mitotic Cell Cycle Regulation Of Cell Growth Regulation Of DNA-templated Transcription Protein Phosphorylation Apoptotic Process Regulation Of Apoptotic Process Regulation Of RNA Splicing Regulation Of Centrosome Cycle Regulation Of MRNA Processing Regulation Of Cell Cycle	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation Proteolysis IRES-dependent Viral Translational Initiation
Pathways		Recruitment of mitotic centrosome proteins and complexes	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs			Quercetin
Diseases
GWAS		Body mass index ( 26426971)	Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Depression (quantitative trait) ( 20800221) Malaria ( 31844061) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		26 interacting genes: AP2M1 CASP1 CASP3 CASP8 CCND3 CCNL2 CHEK2 EIF3F H1-1 KAT7 MSN PAK1 PDE4B PIN1 RANBP9 RNF10 RPS27A TCEA2 TH TPPP URM1 YWHAB YWHAE YWHAG YWHAQ YWHAZ	47 interacting genes: AGR2 APP ATXN1 BTG3 C1orf216 CCDC120 CCDC196 CDC42 CDK11B CDK19 CDSN COL1A2 DKC1 EEF1A1 EIF3M EML2 ERCC6 FBXO32 HAX1 HGS HNRNPK HTR2A KLHL20 LCOR MCPH1 MKRN2 MSH4 MTOR MYDGF MYOZ1 NUP54 OGT PBX4 PKN1 POGZ POU6F2 PTN RABIF RIN1 RPS6KB1 RTP5 SHBG SMAD9 SUOX TEX56P TIMM10B WASHC1
Entrez ID		984	8665
HPRD ID		08909	04887
Ensembl ID		ENSG00000248333	ENSG00000175390
Uniprot IDs		B4DII1 P21127	O00303
PDB IDs		7UKZ	3J8B 3J8C 6YBD 6ZMW 6ZON 6ZP4 6ZVJ 7A09 7QP6 7QP7 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPL 8RG0 8XXN 9BLN
Enriched GO Terms of Interacting Partners?		Phosphoserine Residue Binding Protein Targeting Protein Sequestering Activity Cytosol Nucleus Transmembrane Transporter Binding Focal Adhesion Regulation Of Protein Localization Vesicle Protein Modification Process Cytoplasm Protein Domain Specific Binding Enzyme Binding Post-translational Protein Modification Phosphoprotein Binding Identical Protein Binding Response To Anesthetic Regulation Of Primary Metabolic Process Pyroptotic Inflammatory Response Regulation Of Macromolecule Metabolic Process Cysteine-type Peptidase Activity Death-inducing Signaling Complex Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Immune System Process Positive Regulation Of Pyroptotic Inflammatory Response Ubiquitin Protein Ligase Binding Regulation Of Protein Localization To Nucleus Response To Cobalt Ion Cysteine-type Endopeptidase Activity Negative Regulation Of Intracellular Signal Transduction Regulation Of Metabolic Process Protein Metabolic Process Regulation Of System Process Negative Regulation Of Signal Transduction Interleukin-18-mediated Signaling Pathway Intracellular Signal Transduction Protein Tag Activity Regulation Of Protein Stability Protein Catabolic Process Immune System Process Proteolysis Death Receptor Binding Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Poly-ADP-ribosylation Response To Starvation Positive Regulation Of Myelination Cellular Response To Stress Regulation Of Gene Expression Microtubule Polymerization	Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Glycolytic Process Negative Regulation Of TORC2 Signaling Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of ATP Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Nutrient Positive Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Protein Localization Positive Regulation Of Translational Initiation Memory Positive Regulation Of RNA Biosynthetic Process Intracellular Signaling Cassette Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Programmed Cell Death Positive Regulation Of DNA-templated Transcription Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Pseudopodium Assembly Skin Morphogenesis Regulation Of TORC2 Signaling Regulation Of Supramolecular Fiber Organization TORC2 Signaling Negative Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Gliogenesis Positive Regulation Of TORC1 Signaling TORC1 Signaling Organelle Organization Positive Regulation Of Macromolecule Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Learning Protein Trimerization Positive Regulation Of Transcription By RNA Polymerase III Protein Tyrosine Kinase Activator Activity Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process ATP-dependent DNA Damage Sensor Activity Regulation Of Insulin Receptor Signaling Pathway Regulation Of Gene Expression Response To Auditory Stimulus Mitochondrial Intermembrane Space
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