CDK11B and AP2M1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CDK11B	AP2M1
Description		cyclin dependent kinase 11B	adaptor related protein complex 2 subunit mu 1
Image
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Cytoplasm	Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Membrane AP-2 Adaptor Complex Clathrin Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endolysosome Membrane Synapse Clathrin-coated Endocytic Vesicle Extracellular Exosome Postsynapse Extrinsic Component Of Presynaptic Endocytic Zone Membrane Glutamatergic Synapse
	Molecular Function	Nucleotide Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Signal Sequence Binding Protein Binding Lipid Binding Clathrin Adaptor Activity Transmembrane Transporter Binding Low-density Lipoprotein Particle Receptor Binding Disordered Domain Specific Binding
	Biological Process	Mitotic Cell Cycle Regulation Of Cell Growth Regulation Of DNA-templated Transcription Protein Phosphorylation Apoptotic Process Regulation Of Apoptotic Process Regulation Of RNA Splicing Regulation Of Centrosome Cycle Regulation Of MRNA Processing Regulation Of Cell Cycle	Positive Regulation Of Receptor Internalization Intracellular Protein Transport Endocytosis Vesicle Budding From Membrane Protein Transport Vesicle-mediated Transport Receptor Internalization Synaptic Vesicle Endocytosis Protein-containing Complex Assembly Clathrin-dependent Endocytosis Regulation Of Vesicle Size Postsynaptic Neurotransmitter Receptor Internalization Vesicle-mediated Transport In Synapse Positive Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		Recruitment of mitotic centrosome proteins and complexes	Nef mediated downregulation of CD28 cell surface expression Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Major depressive disorder ( 22472876)
Interacting Genes		26 interacting genes: AP2M1 CASP1 CASP3 CASP8 CCND3 CCNL2 CHEK2 EIF3F H1-1 KAT7 MSN PAK1 PDE4B PIN1 RANBP9 RNF10 RPS27A TCEA2 TH TPPP URM1 YWHAB YWHAE YWHAG YWHAQ YWHAZ	86 interacting genes: ADRA1B AGTR1 AP2B1 AQP4 ARRB2 ATG9A ATXN1L BDKRB2 C1orf35 CACNA1A CD22 CD2BP2 CD3D CDK11B CEBPA CLK2 CORO7 CSNK2B CTLA4 CXorf51A CXorf51B DAB2 DCX DPPA2 DVL2 EAF1 EHD2 EIF1AD FAM90A1 FURIN FXR2 GAK GRIN2A GRIN2B H2BC10 H2BC13 H2BC21 H2BC4 H2BC6 H2BC7 H2BC8 HEXIM2 HOOK2 HTR6 IKZF1 IRS2 KCNJ11 KNOP1 LAMP1 LTB4R2 LUC7L2 LY9 MAB21L3 MED4 MEGF10 MFAP1 MPP1 MTURN NAA11 NCOR2 NDRG1 NKAPD1 PRPF18 PRPF38A PRR13 PTS RALBP1 RNF111 RPL22 RPL38 RRP12 RSPH14 RUNDC3A SFRP4 SNCA SPATS2 STON2 SYNJ1 TASOR TBC1D5 TGOLN2 TIAM1 TMA16 UBC ZBTB8A ZNF581
Entrez ID		984	1173
HPRD ID		08909	03014
Ensembl ID		ENSG00000248333	ENSG00000161203
Uniprot IDs		B4DII1 P21127	B4DNB9 E9PFW3 Q96CW1
PDB IDs		7UKZ	1H6E 6BNT 6URI
Enriched GO Terms of Interacting Partners?		Phosphoserine Residue Binding Protein Targeting Protein Sequestering Activity Cytosol Nucleus Transmembrane Transporter Binding Focal Adhesion Regulation Of Protein Localization Vesicle Protein Modification Process Cytoplasm Protein Domain Specific Binding Enzyme Binding Post-translational Protein Modification Phosphoprotein Binding Identical Protein Binding Response To Anesthetic Regulation Of Primary Metabolic Process Pyroptotic Inflammatory Response Regulation Of Macromolecule Metabolic Process Cysteine-type Peptidase Activity Death-inducing Signaling Complex Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Immune System Process Positive Regulation Of Pyroptotic Inflammatory Response Ubiquitin Protein Ligase Binding Regulation Of Protein Localization To Nucleus Response To Cobalt Ion Cysteine-type Endopeptidase Activity Negative Regulation Of Intracellular Signal Transduction Regulation Of Metabolic Process Protein Metabolic Process Regulation Of System Process Negative Regulation Of Signal Transduction Interleukin-18-mediated Signaling Pathway Intracellular Signal Transduction Protein Tag Activity Regulation Of Protein Stability Protein Catabolic Process Immune System Process Proteolysis Death Receptor Binding Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Poly-ADP-ribosylation Response To Starvation Positive Regulation Of Myelination Cellular Response To Stress Regulation Of Gene Expression Microtubule Polymerization	Innate Immune Response In Mucosa Mucosal Immune Response Organ Or Tissue Specific Immune Response Protein-containing Complex Organization Protein-containing Complex Assembly Protein Heterodimerization Activity Structural Constituent Of Chromatin Antibacterial Humoral Response Nucleosome Assembly Protein Domain Specific Binding Nucleosome Nucleosome Organization Protein-DNA Complex Assembly AP-2 Adaptor Complex Import Into Cell Endocytosis Receptor-mediated Endocytosis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Defense Response To Gram-positive Bacterium Synaptic Vesicle Endocytosis Synaptic Vesicle Uncoating Presynaptic Endocytosis Trans-synaptic Signaling Clathrin Adaptor Activity Synaptic Signaling Clathrin Coat Assembly Nucleoplasm Positive Regulation Of Receptor-mediated Endocytosis Clathrin-coated Endocytic Vesicle Antimicrobial Humoral Response Positive Regulation Of Endocytosis Clathrin Coat Disassembly Regulation Of Neuronal Synaptic Plasticity Regulation Of Endocytosis Chemical Synaptic Transmission Excitatory Postsynaptic Potential Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Vesicle Uncoating Nucleus Positive Regulation Of Receptor Internalization Synaptic Membrane Protein Binding Cellular Component Assembly NMDA Glutamate Receptor Activity Synapse Clathrin-dependent Endocytosis Synaptic Vesicle Regulation Of Vesicle-mediated Transport NMDA Selective Glutamate Receptor Complex
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