DSCAM and STAG1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		DSCAM	STAG1
Description		DS cell adhesion molecule	STAG1 cohesin complex component
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Axon Dendrite Growth Cone Cell Projection Neuronal Cell Body Synapse	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Chromosome Cytosol Cilium Cohesin Complex Nuclear Matrix Nuclear Body Mitotic Cohesin Complex Mitotic Spindle Pole
	Molecular Function	Protein Binding Cell-cell Adhesion Mediator Activity Protein Tyrosine Kinase Binding Netrin Receptor Binding	Chromatin Binding Protein Binding
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Adhesion Nervous System Development Axon Guidance Synapse Assembly Central Nervous System Development Locomotory Behavior Retina Layer Formation Social Behavior Synaptic Transmission, Glutamatergic Netrin-activated Signaling Pathway Positive Regulation Of Phosphorylation Dendrite Morphogenesis Positive Regulation Of Axon Extension Involved In Axon Guidance Post-embryonic Retina Morphogenesis In Camera-type Eye Camera-type Eye Photoreceptor Cell Differentiation Dendritic Spine Development Dendrite Self-avoidance	Chromosome Segregation Sister Chromatid Cohesion Establishment Of Mitotic Sister Chromatid Cohesion Cell Division Mitotic Spindle Assembly
Pathways		DSCAM interactions DSCAM interactions	Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Adult body size ( 32376654) Anxiety in major depressive disorder ( 24047446) Blood protein levels ( 30072576) Fasting plasma glucose ( 31170924) Feeling nervous ( 29500382) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Gut microbiota relative abundance (Prevotella) ( 33208821) Hallux valgus ( 32131869) Intracranial aneurysm ( 30823506) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Mild to moderate chronic kidney disease ( 31178898) Neutrophil count ( 21507922) Non-small cell lung cancer (survival) ( 21079520) Obesity-related traits ( 23251661) Refractive error ( 32231278) Schizophrenia ( 34099189) Schizophrenia x sex interaction ( 34099189) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Systemising ( 31508503) Tuberculosis ( 24057671) Worry/vulnerability (special factor of neuroticism) ( 30867560)	A body shape index ( 34021172) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Apolipoprotein B levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 25673413 28892062) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Central corneal thickness ( 32528159 29760442 31798171) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778) Dentures ( 31235808) General risk tolerance (MTAG) ( 30643258) HDL cholesterol ( 30275531) Height ( 25282103) Intraocular pressure ( 29617998) LDL cholesterol levels ( 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Multisite chronic pain ( 31194737 33830993) Myocardial infarction ( 33532862) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Plateletcrit ( 32888494) Schizophrenia ( 30285260 29483656 28991256 25056061) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		157 interacting genes: ACO1 ACTN1 ACTN4 AFDN AMOTL2 AP2A1 AP2B1 APC2 ARCN1 ARIH2 ASTN1 ATP5F1B ATP6V1B2 ATRX BFSP1 BICD1 BTBD1 CADPS CAMK2A CAP2 CEP63 CFAP91 CIAO2B CIT CLTC CLU COG1 COG4 COPS5 CPNE5 CRTAC1 CSNK2B CUL9 CXXC5 DIP2A DLG1 DLG2 DLG4 DNAJA2 DPYSL2 DST DYNC1H1 DYRK1A EEF2 EIF3C ENC1 EYA3 FLNB GFAP GFPT1 GLUL GNPTAB GPRASP1 GUF1 HLA-A HNRNPF IFT122 IFT88 INTS8 IQGAP1 IST1 KALRN KCNN1 KDM4C KHDRBS1 KIF21A KIF3A KIF5A KIFC3 KLHL4 KPNB1 KRT222 KRT83 LARS1 LDB1 LIMK1 LMO2 LNX1 MACF1 MAGI2 MAGI3 MAP3K11 MAP4K4 MAT2A MERTK METAP1 METAP2 MITD1 MNAT1 MORF4L2 MPRIP MTA3 MTMR10 NAPA NAPB NCK1 NEFL NEFM NF2 NOMO2 NUP43 PAK1 PAX6 PDE4DIP PDLIM5 PIH1D2 PLEC POLDIP2 POLR3B PPP1R16B PRPF8 PSMD2 PTPN13 RAPGEF4 RCBTB1 RILPL1 ROBO1 RTL10 RUFY2 RUFY3 S100A10 SACS SDHA SEMA4D SEPTIN2 SGSM3 SHTN1 SIPA1L1 SKIL SOS2 SPTBN1 STAG1 STAT3 SUPT5H SUPV3L1 SYNE1 SYNGAP1 TARS3 TFIP11 TRIM37 TRIP11 TTC17 TTC7B UBA3 UQCRC1 USP11 VIM VPS54 WARS1 WASHC4 WDR13 WDR59 XRN2 ZBTB43 ZBTB47 ZNF202 ZNF365	7 interacting genes: CALM1 DSCAM RAD21 SMAD2 SMAD9 STAG2 WFDC5
Entrez ID		1826	10274
HPRD ID		03953	05076
Ensembl ID		ENSG00000171587	ENSG00000118007
Uniprot IDs		O60469	Q8WVM7
PDB IDs		6ZR7	5QSM 5QSN 5QSO 5QSP 5QSQ 5QSR 5QSS 5QST 5QSU 5QSV 5QSW 5QSX 5QSY 5QSZ 6QB5 6R7O 6RRC 6RRK 6WG3 7W1M
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organelle Organization Cytoplasm Cytoskeleton Organization Regulation Of Cellular Component Organization Cytosol Regulation Of Neuron Projection Development Positive Regulation Of Axonogenesis Intracellular Protein Localization Regulation Of Cell Projection Organization Cellular Localization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Axonogenesis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Nervous System Development Supramolecular Fiber Organization Cell Projection Actin Filament Binding Protein Binding Regulation Of Nervous System Development Positive Regulation Of Cellular Component Organization Establishment Of Localization In Cell Positive Regulation Of Neurogenesis Establishment Of Protein Localization Identical Protein Binding Positive Regulation Of Cell Projection Organization Regulation Of Neurogenesis Epithelial Cell Development Protein Transport Postsynaptic Density Retrograde Axonal Transport Intracellular Transport Microtubule-based Process Positive Regulation Of Nervous System Development Axon Cytoplasm Axonal Transport Actin Binding Cytoskeleton-dependent Intracellular Transport Intermediate Filament Developmental Process Neuron Projection Microtubule Structural Constituent Of Cytoskeleton Microtubule Cytoskeleton Organization Intermediate Filament Organization Transport Along Microtubule Axon Intermediate Filament Cytoskeleton Cadherin Binding	Cohesin Complex Meiotic Cohesin Complex Sister Chromatid Cohesion Heteromeric SMAD Protein Complex SMAD Protein Complex Establishment Of Sister Chromatid Cohesion Establishment Of Mitotic Sister Chromatid Cohesion Mitotic Cohesin Complex Regulation Of Cell Communication By Electrical Coupling Detection Of Calcium Ion I-SMAD Binding Chromatin Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion SMAD Protein Signal Transduction Calcium Channel Complex Spindle Pole Chromosome, Centromeric Region Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum DGDP Biosynthetic Process GDP Biosynthetic Process Organ Growth Condensed Nuclear Chromosome Calcitriol Binding Lithocholic Acid Binding Histone H2B Ubiquitin Ligase Activity Peptidyl-aspartic Acid 3-dioxygenase Activity Nucleoplasm Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Homomeric SMAD Protein Complex Negative Regulation Of Phosphate Transmembrane Transport Nuclear Receptor-mediated Bile Acid Signaling Pathway Bile Acid Nuclear Receptor Activity Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Roof Of Mouth Development Intracellular Signal Transduction Regulation Of Cardiac Muscle Contraction Regulation Of Monoatomic Ion Transmembrane Transporter Activity Glycoprotein Transport Zygotic Specification Of Dorsal/ventral Axis Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Cis-regulatory Region Sequence-specific DNA Binding Establishment Of Meiotic Sister Chromatid Cohesion Chromosome Organization
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