DSCAM and PRPF8

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		DSCAM	PRPF8
Description		DS cell adhesion molecule	pre-mRNA processing factor 8
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Axon Dendrite Growth Cone Cell Projection Neuronal Cell Body Synapse	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP Membrane Nuclear Speck Small Nuclear Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome U2-type Catalytic Step 1 Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex
	Molecular Function	Protein Binding Cell-cell Adhesion Mediator Activity Protein Tyrosine Kinase Binding Netrin Receptor Binding	RNA Binding Protein Binding Peptidase Activity U6 SnRNA Binding U1 SnRNA Binding U2 SnRNA Binding U5 SnRNA Binding K63-linked Polyubiquitin Modification-dependent Protein Binding Pre-mRNA Intronic Binding Metal-dependent Deubiquitinase Activity
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Adhesion Nervous System Development Axon Guidance Synapse Assembly Central Nervous System Development Locomotory Behavior Retina Layer Formation Social Behavior Synaptic Transmission, Glutamatergic Netrin-activated Signaling Pathway Positive Regulation Of Phosphorylation Dendrite Morphogenesis Positive Regulation Of Axon Extension Involved In Axon Guidance Post-embryonic Retina Morphogenesis In Camera-type Eye Camera-type Eye Photoreceptor Cell Differentiation Dendritic Spine Development Dendrite Self-avoidance	Spliceosomal Tri-snRNP Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Cellular Response To Lipopolysaccharide Cellular Response To Tumor Necrosis Factor
Pathways		DSCAM interactions DSCAM interactions	mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs
Diseases			Retinitis pigmentosa (RP)
GWAS		Adult body size ( 32376654) Anxiety in major depressive disorder ( 24047446) Blood protein levels ( 30072576) Fasting plasma glucose ( 31170924) Feeling nervous ( 29500382) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Gut microbiota relative abundance (Prevotella) ( 33208821) Hallux valgus ( 32131869) Intracranial aneurysm ( 30823506) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Mild to moderate chronic kidney disease ( 31178898) Neutrophil count ( 21507922) Non-small cell lung cancer (survival) ( 21079520) Obesity-related traits ( 23251661) Refractive error ( 32231278) Schizophrenia ( 34099189) Schizophrenia x sex interaction ( 34099189) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Systemising ( 31508503) Tuberculosis ( 24057671) Worry/vulnerability (special factor of neuroticism) ( 30867560)	Calcium levels ( 20705733) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494)
Interacting Genes		157 interacting genes: ACO1 ACTN1 ACTN4 AFDN AMOTL2 AP2A1 AP2B1 APC2 ARCN1 ARIH2 ASTN1 ATP5F1B ATP6V1B2 ATRX BFSP1 BICD1 BTBD1 CADPS CAMK2A CAP2 CEP63 CFAP91 CIAO2B CIT CLTC CLU COG1 COG4 COPS5 CPNE5 CRTAC1 CSNK2B CUL9 CXXC5 DIP2A DLG1 DLG2 DLG4 DNAJA2 DPYSL2 DST DYNC1H1 DYRK1A EEF2 EIF3C ENC1 EYA3 FLNB GFAP GFPT1 GLUL GNPTAB GPRASP1 GUF1 HLA-A HNRNPF IFT122 IFT88 INTS8 IQGAP1 IST1 KALRN KCNN1 KDM4C KHDRBS1 KIF21A KIF3A KIF5A KIFC3 KLHL4 KPNB1 KRT222 KRT83 LARS1 LDB1 LIMK1 LMO2 LNX1 MACF1 MAGI2 MAGI3 MAP3K11 MAP4K4 MAT2A MERTK METAP1 METAP2 MITD1 MNAT1 MORF4L2 MPRIP MTA3 MTMR10 NAPA NAPB NCK1 NEFL NEFM NF2 NOMO2 NUP43 PAK1 PAX6 PDE4DIP PDLIM5 PIH1D2 PLEC POLDIP2 POLR3B PPP1R16B PRPF8 PSMD2 PTPN13 RAPGEF4 RCBTB1 RILPL1 ROBO1 RTL10 RUFY2 RUFY3 S100A10 SACS SDHA SEMA4D SEPTIN2 SGSM3 SHTN1 SIPA1L1 SKIL SOS2 SPTBN1 STAG1 STAT3 SUPT5H SUPV3L1 SYNE1 SYNGAP1 TARS3 TFIP11 TRIM37 TRIP11 TTC17 TTC7B UBA3 UQCRC1 USP11 VIM VPS54 WARS1 WASHC4 WDR13 WDR59 XRN2 ZBTB43 ZBTB47 ZNF202 ZNF365	21 interacting genes: ABCA1 DHX9 DSCAM DUX4 ERG GPKOW H2BC5 HNRNPH2 NEDD4 PIN1 PTEN RNF20 SERPINB2 SLC22A2 SND1 SUMO2 TP53 UBC UBE2I USP7 ZNF830
Entrez ID		1826	10594
HPRD ID		03953	06295
Ensembl ID		ENSG00000171587	ENSG00000174231
Uniprot IDs		O60469	Q6P2Q9
PDB IDs		6ZR7	3E9L 3ENB 3JCR 3LRU 4JK7 4JK8 4JK9 4JKA 4JKB 4JKC 4JKD 4JKE 4JKF 4JKG 4JKH 4KIT 5MQF 5O9Z 5XJC 5YZG 5Z56 5Z57 5Z58 6AH0 6AHD 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6QW6 6QX9 6S8Q 6S9I 6ZYM 7A5P 7AAV 7ABF 7ABG 7ABI 7BDI 7BDJ 7BDK 7BDL 7DVQ 7OS2 7PJH 7PX3 7QTT 7W59 7W5A 7W5B 8BC8 8BC9 8BCA 8BCB 8BCC 8BCD 8BCE 8BCF 8BCG 8C6J 8CH6 8H6E 8H6J 8H6K 8H6L 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8Q7N 8Q7Q 8Q7V 8Q7W 8Q7X 8Q91 8QO9 8QOZ 8QP8 8QP9 8QPA 8QPB 8QPE 8QPK 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RC0 8RM5 8RO2 8Y6O 9FMD
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organelle Organization Cytoplasm Cytoskeleton Organization Regulation Of Cellular Component Organization Cytosol Regulation Of Neuron Projection Development Positive Regulation Of Axonogenesis Intracellular Protein Localization Regulation Of Cell Projection Organization Cellular Localization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Axonogenesis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Nervous System Development Supramolecular Fiber Organization Cell Projection Actin Filament Binding Protein Binding Regulation Of Nervous System Development Positive Regulation Of Cellular Component Organization Establishment Of Localization In Cell Positive Regulation Of Neurogenesis Establishment Of Protein Localization Identical Protein Binding Positive Regulation Of Cell Projection Organization Regulation Of Neurogenesis Epithelial Cell Development Protein Transport Postsynaptic Density Retrograde Axonal Transport Intracellular Transport Microtubule-based Process Positive Regulation Of Nervous System Development Axon Cytoplasm Axonal Transport Actin Binding Cytoskeleton-dependent Intracellular Transport Intermediate Filament Developmental Process Neuron Projection Microtubule Structural Constituent Of Cytoskeleton Microtubule Cytoskeleton Organization Intermediate Filament Organization Transport Along Microtubule Axon Intermediate Filament Cytoskeleton Cadherin Binding	Postsynaptic Cytosol PML Body Nucleoplasm Phosphothreonine Residue Binding Macromolecule Metabolic Process Rhythmic Process Nucleus RISC Complex Binding Phosphoserine Residue Binding MRNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Protein Modification Process Ubiquitin Ligase Activator Activity P53 Binding Regulation Of Telomere Capping Protein Tag Activity Protein Modification By Small Protein Conjugation RNA Polymerase Binding Synapse Organization Protein Stabilization Regulation Of Cell Cycle Process Regulation Of Cell Cycle SUMO Transferase Activity RNA Binding Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Process Circadian Behavior Rhythmic Behavior Regulation Of Telomere Maintenance Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Post-translational Protein Modification Ubiquitin Protein Ligase Binding Presynaptic Cytosol Osteoblast Differentiation Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleic Acid Binding Regulation Of Phosphorus Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Viral Process Central Nervous System Development Sphingolipid Floppase Activity 3'-5' DNA/RNA Helicase Activity Nuclear Body DNA-templated Viral Transcription Negative Regulation Of Catabolic Process
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