DSCAM and LMO2

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		DSCAM	LMO2
Description		DS cell adhesion molecule	LIM domain only 2
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Axon Dendrite Growth Cone Cell Projection Neuronal Cell Body Synapse	Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	Protein Binding Cell-cell Adhesion Mediator Activity Protein Tyrosine Kinase Binding Netrin Receptor Binding	Transcription Coregulator Binding Transcription Coactivator Activity Protein Binding Identical Protein Binding BHLH Transcription Factor Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Adhesion Nervous System Development Axon Guidance Synapse Assembly Central Nervous System Development Locomotory Behavior Retina Layer Formation Social Behavior Synaptic Transmission, Glutamatergic Netrin-activated Signaling Pathway Positive Regulation Of Phosphorylation Dendrite Morphogenesis Positive Regulation Of Axon Extension Involved In Axon Guidance Post-embryonic Retina Morphogenesis In Camera-type Eye Camera-type Eye Photoreceptor Cell Differentiation Dendritic Spine Development Dendrite Self-avoidance	Positive Regulation Of Transcription By RNA Polymerase II
Pathways		DSCAM interactions DSCAM interactions	RUNX1 regulates transcription of genes involved in differentiation of HSCs
Drugs
Diseases			Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Adult body size ( 32376654) Anxiety in major depressive disorder ( 24047446) Blood protein levels ( 30072576) Fasting plasma glucose ( 31170924) Feeling nervous ( 29500382) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Gut microbiota relative abundance (Prevotella) ( 33208821) Hallux valgus ( 32131869) Intracranial aneurysm ( 30823506) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Mild to moderate chronic kidney disease ( 31178898) Neutrophil count ( 21507922) Non-small cell lung cancer (survival) ( 21079520) Obesity-related traits ( 23251661) Refractive error ( 32231278) Schizophrenia ( 34099189) Schizophrenia x sex interaction ( 34099189) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Systemising ( 31508503) Tuberculosis ( 24057671) Worry/vulnerability (special factor of neuroticism) ( 30867560)	Cognitive performance ( 19734545) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Major depressive disorder x sex interaction ( 34099189) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Red blood cell count ( 27863252 32888494)
Interacting Genes		157 interacting genes: ACO1 ACTN1 ACTN4 AFDN AMOTL2 AP2A1 AP2B1 APC2 ARCN1 ARIH2 ASTN1 ATP5F1B ATP6V1B2 ATRX BFSP1 BICD1 BTBD1 CADPS CAMK2A CAP2 CEP63 CFAP91 CIAO2B CIT CLTC CLU COG1 COG4 COPS5 CPNE5 CRTAC1 CSNK2B CUL9 CXXC5 DIP2A DLG1 DLG2 DLG4 DNAJA2 DPYSL2 DST DYNC1H1 DYRK1A EEF2 EIF3C ENC1 EYA3 FLNB GFAP GFPT1 GLUL GNPTAB GPRASP1 GUF1 HLA-A HNRNPF IFT122 IFT88 INTS8 IQGAP1 IST1 KALRN KCNN1 KDM4C KHDRBS1 KIF21A KIF3A KIF5A KIFC3 KLHL4 KPNB1 KRT222 KRT83 LARS1 LDB1 LIMK1 LMO2 LNX1 MACF1 MAGI2 MAGI3 MAP3K11 MAP4K4 MAT2A MERTK METAP1 METAP2 MITD1 MNAT1 MORF4L2 MPRIP MTA3 MTMR10 NAPA NAPB NCK1 NEFL NEFM NF2 NOMO2 NUP43 PAK1 PAX6 PDE4DIP PDLIM5 PIH1D2 PLEC POLDIP2 POLR3B PPP1R16B PRPF8 PSMD2 PTPN13 RAPGEF4 RCBTB1 RILPL1 ROBO1 RTL10 RUFY2 RUFY3 S100A10 SACS SDHA SEMA4D SEPTIN2 SGSM3 SHTN1 SIPA1L1 SKIL SOS2 SPTBN1 STAG1 STAT3 SUPT5H SUPV3L1 SYNE1 SYNGAP1 TARS3 TFIP11 TRIM37 TRIP11 TTC17 TTC7B UBA3 UQCRC1 USP11 VIM VPS54 WARS1 WASHC4 WDR13 WDR59 XRN2 ZBTB43 ZBTB47 ZNF202 ZNF365	190 interacting genes: ABI2 ADAMTSL4 AFDN AGTRAP AIMP2 AIRIM ALDH6A1 ARHGEF5 ARID5A ARNT2 ATOSB AXIN1 BANP BCAS2 BEX2 BLZF1 BYSL C1orf94 CALCOCO2 CBY2 CCDC33 CDC25A CDC5L CDX4 CLHC1 CMTM5 CORO1A CORO1C DAZAP2 DBF4B DDIT3 DMRT3 DRAP1 DRC4 DSCAM DYDC1 EFHC1 EFHC2 EHMT2 EIF3B EIF4EBP1 ELF2 ENKD1 ERBIN FAAP20 FAM228A FAM90A1 FHL3 FHL5 GATA1 GATA2 GATA3 GFAP GMEB2 GOLGA2 GRB2 HDAC5 HNRNPC HNRNPM HOOK1 ICA1L IFT43 IHO1 IKZF1 IKZF3 INCA1 ISL1 ISY1 KANK2 KAZN KDM5A KIF2A KIF3B KLHL20 KPRP KRT15 KRT34 KRT40 KRT75 KRT80 KRTAP10-7 LDB1 LDB2 LDOC1 LMO4 LMOD3 LYL1 LZTS1 LZTS2 MAGEA8 MAPRE1 MAPRE2 MAPRE3 MBIP MISP MRFAP1L1 MSN MTUS2 MYOZ3 N4BP2L2 NCAPH2 NDOR1 NDUFAB1 NDUFB7 NFKBID NHLH1 NIF3L1 NOTCH2NLA NOXA1 NSMF NTAQ1 NUP62 NUTM1 PATZ1 PAX9 PBX4 PDE9A PHC2 POLR2G PRDM6 PRKG1 PSMA1 RBBP8 RCN1 REL RELA RINT1 RLIM ROCK1 RTL8C RUSC1 SAXO1 SAXO4 SGTB SKP1 SMAD2 SMUG1 SNAPC5 SOX5 SP1 SSX2IP STAT1 STAT3 STIP1 TAL1 TAL2 TBX2 TCP10L TEKT3 TFIP11 TFPT THAP6 TLE5 TLX3 TRIB3 TRIM23 TRIM54 TRIM55 TRIM63 TRIP6 TSC1 TSC22D4 TSEN15 TSEN54 TSGA10IP TSPYL2 TSSK3 TUFT1 UBA6 UBASH3B UBE2I USH1G VBP1 VEZF1 VMAC WASF1 WASHC1 YOD1 YPEL3 ZFP64 ZMYND12 ZNF185 ZNF19 ZNF24 ZNF250 ZNF34 ZNF410 ZNF641 ZNF655 ZNF688
Entrez ID		1826	4005
HPRD ID		03953	01586
Ensembl ID		ENSG00000171587	ENSG00000135363
Uniprot IDs		O60469	P25791
PDB IDs		6ZR7	2XJY 2XJZ 2YPA 4KFZ
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organelle Organization Cytoplasm Cytoskeleton Organization Regulation Of Cellular Component Organization Cytosol Regulation Of Neuron Projection Development Positive Regulation Of Axonogenesis Intracellular Protein Localization Regulation Of Cell Projection Organization Cellular Localization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Axonogenesis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Nervous System Development Supramolecular Fiber Organization Cell Projection Actin Filament Binding Protein Binding Regulation Of Nervous System Development Positive Regulation Of Cellular Component Organization Establishment Of Localization In Cell Positive Regulation Of Neurogenesis Establishment Of Protein Localization Identical Protein Binding Positive Regulation Of Cell Projection Organization Regulation Of Neurogenesis Epithelial Cell Development Protein Transport Postsynaptic Density Retrograde Axonal Transport Intracellular Transport Microtubule-based Process Positive Regulation Of Nervous System Development Axon Cytoplasm Axonal Transport Actin Binding Cytoskeleton-dependent Intracellular Transport Intermediate Filament Developmental Process Neuron Projection Microtubule Structural Constituent Of Cytoskeleton Microtubule Cytoskeleton Organization Intermediate Filament Organization Transport Along Microtubule Axon Intermediate Filament Cytoskeleton Cadherin Binding	Protein Binding Nucleus Identical Protein Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Cytoskeleton Regulation Of RNA Metabolic Process Cytoskeleton Organization Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Metabolic Process Transcription Regulator Complex Nucleoplasm Chromatin Sequence-specific DNA Binding Regulation Of Metabolic Process Mitotic Spindle Astral Microtubule End Cellular Developmental Process Microtubule DNA-binding Transcription Factor Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Macromolecule Metabolic Process Cell Differentiation Cytoplasm Microtubule Cytoskeleton Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Spindle Assembly Microtubule-based Process Neuron Fate Specification Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Erythrocyte Differentiation Microtubule Binding Developmental Process Transcription Cis-regulatory Region Binding Positive Regulation Of Erythrocyte Differentiation
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