OTX2 and AURKC

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		OTX2	AURKC
Name		orthodenticle homeobox 2	aurora kinase C
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Growth Cone Protein-containing Complex	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Spindle Pole Nucleus Chromosome Cytoplasm Centrosome Spindle Cytoskeleton Spindle Microtubule Midbody Chromosome Passenger Complex Spindle Midzone
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Eukaryotic Initiation Factor 4E Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Axon Guidance Regulation Of Smoothened Signaling Pathway Forebrain Development Midbrain Development Positive Regulation Of Embryonic Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Assembly Dopaminergic Neuron Differentiation Primitive Streak Formation Positive Regulation Of Gastrulation	Protein Phosphorylation Mitotic Spindle Organization Attachment Of Spindle Microtubules To Kinetochore Regulation Of Cytokinesis Positive Regulation Of Cytokinesis Mitotic Spindle Midzone Assembly Cell Division Meiotic Cell Cycle
Pathways		Formation of the anterior neural plate Formation of the posterior neural plate	None
Drugs		None	SNS-314 Fostamatinib
Diseases		Anophthalmia and microphthalmia (A/M) Septo-optic dysplasia	None
GWAS		Alcohol consumption ( 31358974 ) Alcohol consumption (drinks per week) ( 30643258 ) Chronotype ( 30696823 ) Lung cancer ( 31577861 ) Moderate-to-late spontaneous preterm birth ( 31194736 ) Refractive error ( 32231278 )	No GWAS studies recorded
Interacting Genes		44 interacting genes: APP ASIC4 ATP6V1G3 ATXN1 AURKC B4GALNT2 BNIP2 CDK3 CDK4 DMBX1 EIF4E FOXA2 GPR45 GUCA1B HIKESHI HNF1B HOMER3 HSD3B7 IQGAP1 JPT1 KLF3 LHX1 M1AP MITF NAA50 OR1L3 OR6C1 POLDIP3 RBM47 RNASE11 RPS26 RTCA SMARCB1 SNRPA TBCEL TENT5B TLE4 TMEM11 TNPO2 TRMT10B ZC3H10 ZDHHC17 ZNF765 ZNHIT1	13 interacting genes: BIRC5 BIRC7 BRCA1 CADPS CENPA H3C1 INCENP LNX1 NEDD4 NEDD4L OTX2 SRPK1 TACC2
Entrez ID		5015	6795
HPRD ID		07190	04605
Ensembl ID		ENSG00000165588	ENSG00000105146
Uniprot IDs		F1T0C9 F1T0D0 F1T0D1 P32243	Q9UQB9
PDB IDs		Not available	6GR8 6GR9 9ESA
GO Terms Enriched among Interactors		Adult Locomotory Behavior Regulation Of DNA-templated Transcription Initiation Nephric Duct Development Mesonephric Duct Development Positive Regulation Of Gene Expression, Epigenetic Developmental Growth Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Protein Binding Nucleus Transcription Regulator Complex Primitive Streak Formation Positive Regulation Of Gastrulation Pronephros Development Nephric Duct Morphogenesis Developmental Growth Involved In Morphogenesis Nuclear Transport Nucleocytoplasmic Transport Adult Behavior Regulation Of Gastrulation Negative Regulation Of Transcription By RNA Polymerase II	Ubiquitin-protein Transferase Activity Chromosome Segregation Microtubule Cytoskeleton Organization Involved In Mitosis Chromosome Ubiquitin Protein Ligase Activity Chromosome Passenger Complex Negative Regulation Of Potassium Ion Export Across Plasma Membrane Protein-containing Complex Organelle Localization Mitotic Cytokinesis Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Sodium Channel Inhibitor Activity Mitotic Spindle Midzone Assembly Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Potassium Channel Inhibitor Activity Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Spindle Midzone Assembly Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Mitotic Cytokinesis Regulation Of Metaphase Plate Congression Mitotic Spindle Organization Cytoskeleton-dependent Cytokinesis Regulation Of Mitotic Cytokinesis Lateral Element Negative Regulation Of Sodium Ion Transport Nucleoplasm Protein Ubiquitination Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Positive Regulation Of Cell Cycle Checkpoint RNA Polymerase Binding Receptor Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Enzyme Binding Microtubule-based Process Spindle Organization Chromosome, Centromeric Region Positive Regulation Of Chromosome Segregation Pericentric Heterochromatin Negative Regulation Of Potassium Ion Transport Post-translational Protein Modification Cysteine-type Endopeptidase Inhibitor Activity Microtubule Cytoskeleton Organization Positive Regulation Of Chromosome Separation Neuromuscular Junction Development Positive Regulation Of Cytokinesis