OTX2 and RPS26

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		OTX2	RPS26
Description		orthodenticle homeobox 2	ribosomal protein S26
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Growth Cone Protein-containing Complex	Nucleoplasm Cytoplasm Endoplasmic Reticulum Rough Endoplasmic Reticulum Cytosol Ribosome Small Ribosomal Subunit Membrane Cytosolic Ribosome Cytosolic Small Ribosomal Subunit Synapse Extracellular Exosome Cytoplasmic Side Of Rough Endoplasmic Reticulum Membrane Ribonucleoprotein Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Eukaryotic Initiation Factor 4E Binding Sequence-specific Double-stranded DNA Binding	RNA Binding MRNA Binding Structural Constituent Of Ribosome Protein Binding Cadherin Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Axon Guidance Regulation Of Smoothened Signaling Pathway Forebrain Development Midbrain Development Positive Regulation Of Embryonic Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Assembly Dopaminergic Neuron Differentiation Primitive Streak Formation Positive Regulation Of Gastrulation	Cytoplasmic Translation Translation Negative Regulation Of RNA Splicing
Pathways		Formation of the anterior neural plate Formation of the posterior neural plate	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency SARS-CoV-1 modulates host translation machinery SARS-CoV-2 modulates host translation machinery Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases		Anophthalmia and microphthalmia (A/M) Septo-optic dysplasia	Diamond-Blackfan anemia (DBA)
GWAS		Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Chronotype ( 30696823) Lung cancer ( 31577861) Moderate-to-late spontaneous preterm birth ( 31194736) Refractive error ( 32231278)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Anorexia nervosa ( 28494655) Asthma ( 31959851 31619474 30929738) Asthma (adult onset) ( 30929738) Asthma (moderate or severe) ( 30552067) Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive function ( 25644384) Hypothyroidism ( 27182965) Inflammatory skin disease ( 25574825) Liver enzyme levels (alanine transaminase) ( 33972514) Lymphocyte count ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (thyroid preparations) ( 31015401) Nonsyndromic cleft lip with cleft palate ( 28232668) Psoriasis ( 25574825 20953189) Refractive error ( 32231278) Vitiligo ( 22951725)
Interacting Genes		44 interacting genes: APP ASIC4 ATP6V1G3 ATXN1 AURKC B4GALNT2 BNIP2 CDK3 CDK4 DMBX1 EIF4E FOXA2 GPR45 GUCA1B HIKESHI HNF1B HOMER3 HSD3B7 IQGAP1 JPT1 KLF3 LHX1 M1AP MITF NAA50 OR1L3 OR6C1 POLDIP3 RBM47 RNASE11 RPS26 RTCA SMARCB1 SNRPA TBCEL TENT5B TLE4 TMEM11 TNPO2 TRMT10B ZC3H10 ZDHHC17 ZNF765 ZNHIT1	7 interacting genes: APP NDRG1 OTX2 PTEN SDCBP SRPK2 TSR2
Entrez ID		5015	6231
HPRD ID		07190	04743
Ensembl ID		ENSG00000165588	ENSG00000197728
Uniprot IDs		F1T0C9 F1T0D0 F1T0D1 P32243	P62854
PDB IDs			4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6G5H 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBD 6YBW 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMW 6ZN5 6ZOJ 6ZOK 6ZON 6ZP4 6ZV6 6ZVH 6ZVJ 6ZXG 6ZXH 7A09 7K5I 7QP6 7QP7 7R4X 7TQL 7XNX 7XNY 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IFD 8IFE 8JDJ 8JDK 8JDL 8JDM 8K2C 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPK 8PPL 8QOI 8RG0 8T4S 8UKB 8XP2 8XP3 8XSX 8XSY 8XSZ 8XXL 8XXM 8XXN 8Y0W 8Y0X 8YOO 8YOP 8ZDB 9BKD 9BLN 9C3H 9G8M 9G8O
Enriched GO Terms of Interacting Partners?		Adult Locomotory Behavior Regulation Of DNA-templated Transcription Initiation Nephric Duct Development Mesonephric Duct Development Positive Regulation Of Gene Expression, Epigenetic Developmental Growth Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Protein Binding Nucleus Transcription Regulator Complex Primitive Streak Formation Positive Regulation Of Gastrulation Pronephros Development Nephric Duct Morphogenesis Developmental Growth Involved In Morphogenesis Nuclear Transport Nucleocytoplasmic Transport Adult Behavior Regulation Of Gastrulation Negative Regulation Of Transcription By RNA Polymerase II	Myelin Maintenance Amyloid-beta Complex Growth Cone Lamellipodium Neuron Projection Organization Plasma Membrane Bounded Cell Projection Organization Trans-synaptic Signaling Chemical Synaptic Transmission Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Excitatory Postsynaptic Potential Intracellular Signaling Cassette Regulation Of Cell Population Proliferation Amylin Binding Positive Regulation Of Toll Signaling Pathway Synaptic Signaling Frizzled Binding Modulation Of Excitatory Postsynaptic Potential Reproductive Behavior Ribonucleotide Binding Negative Regulation Of Synaptic Vesicle Clustering Interleukin-5 Receptor Complex Intracellular Signal Transduction Regulation Of Receptor Internalization Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of JNK Cascade Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Neuron Projection Development Regulation Of Receptor-mediated Endocytosis Lipoprotein Particle Cell Projection Organization Regulation Of Mitotic Cell Cycle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Regulation Of Nervous System Process Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Cell Cycle Plasma Membrane Organization Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Central Nervous System Myelin Maintenance Regulation Of Epithelial To Mesenchymal Transition Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Rhythmic Synaptic Transmission
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