OTX2 and GUCA1B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		OTX2	GUCA1B
Description		orthodenticle homeobox 2	guanylate cyclase activator 1B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Growth Cone Protein-containing Complex	Photoreceptor Outer Segment Photoreceptor Inner Segment Nucleoplasm Plasma Membrane Cilium Microtubule Cytoskeleton Membrane Nuclear Membrane Ciliary Basal Body Cell Projection Photoreceptor Disc Membrane Cone Photoreceptor Outer Segment
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Eukaryotic Initiation Factor 4E Binding Sequence-specific Double-stranded DNA Binding	Calcium Ion Binding Protein Binding Calcium Sensitive Guanylate Cyclase Activator Activity Guanylate Cyclase Regulator Activity Metal Ion Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Axon Guidance Regulation Of Smoothened Signaling Pathway Forebrain Development Midbrain Development Positive Regulation Of Embryonic Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Assembly Dopaminergic Neuron Differentiation Primitive Streak Formation Positive Regulation Of Gastrulation	Receptor Guanylyl Cyclase Signaling Pathway Cell-cell Signaling Body Fluid Secretion Visual Perception Phototransduction Regulation Of Signal Transduction
Pathways		Formation of the anterior neural plate Formation of the posterior neural plate	Inactivation, recovery and regulation of the phototransduction cascade
Drugs
Diseases		Anophthalmia and microphthalmia (A/M) Septo-optic dysplasia	Retinitis pigmentosa (RP)
GWAS		Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Chronotype ( 30696823) Lung cancer ( 31577861) Moderate-to-late spontaneous preterm birth ( 31194736) Refractive error ( 32231278)
Interacting Genes		44 interacting genes: APP ASIC4 ATP6V1G3 ATXN1 AURKC B4GALNT2 BNIP2 CDK3 CDK4 DMBX1 EIF4E FOXA2 GPR45 GUCA1B HIKESHI HNF1B HOMER3 HSD3B7 IQGAP1 JPT1 KLF3 LHX1 M1AP MITF NAA50 OR1L3 OR6C1 POLDIP3 RBM47 RNASE11 RPS26 RTCA SMARCB1 SNRPA TBCEL TENT5B TLE4 TMEM11 TNPO2 TRMT10B ZC3H10 ZDHHC17 ZNF765 ZNHIT1	3 interacting genes: GUCY2D GUCY2F OTX2
Entrez ID		5015	2979
HPRD ID		07190	03783
Ensembl ID		ENSG00000165588	ENSG00000112599
Uniprot IDs		F1T0C9 F1T0D0 F1T0D1 P32243	Q9UMX6
PDB IDs
Enriched GO Terms of Interacting Partners?		Adult Locomotory Behavior Regulation Of DNA-templated Transcription Initiation Nephric Duct Development Mesonephric Duct Development Positive Regulation Of Gene Expression, Epigenetic Developmental Growth Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Protein Binding Nucleus Transcription Regulator Complex Primitive Streak Formation Positive Regulation Of Gastrulation Pronephros Development Nephric Duct Morphogenesis Developmental Growth Involved In Morphogenesis Nuclear Transport Nucleocytoplasmic Transport Adult Behavior Regulation Of Gastrulation Negative Regulation Of Transcription By RNA Polymerase II	Peptide Receptor Activity Guanylate Cyclase Activity Receptor Guanylyl Cyclase Signaling Pathway Regulation Of Opsin-mediated Signaling Pathway CGMP Biosynthetic Process CGMP Metabolic Process Phosphorus-oxygen Lyase Activity Photoreceptor Disc Membrane Cyclic Nucleotide Biosynthetic Process CGMP-mediated Signaling Nuclear Outer Membrane Cyclic Purine Nucleotide Metabolic Process Purine Ribonucleotide Biosynthetic Process Lyase Activity Ribose Phosphate Biosynthetic Process Regulation Of G Protein-coupled Receptor Signaling Pathway Purine Nucleotide Biosynthetic Process Visual Perception Sensory Perception Of Light Stimulus Nucleotide Biosynthetic Process Purine-containing Compound Biosynthetic Process Signaling Receptor Activity Nucleoside Phosphate Biosynthetic Process Purine Ribonucleotide Metabolic Process Positive Regulation Of Gastrulation Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Eukaryotic Initiation Factor 4E Binding Rod Photoreceptor Outer Segment Protein-containing Complex Binding GTP Binding Purine Nucleotide Metabolic Process Photoreceptor Outer Segment Membrane Primitive Streak Formation Nucleotide Metabolic Process Regulation Of Gastrulation Sensory Perception Carbohydrate Derivative Biosynthetic Process Purine-containing Compound Metabolic Process Positive Regulation Of Embryonic Development Protein Kinase Activity Detection Of Light Stimulus Involved In Visual Perception Organophosphate Biosynthetic Process Nucleoside Phosphate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Midbrain Development Dopaminergic Neuron Differentiation Enzyme-linked Receptor Protein Signaling Pathway Protein Sequestering Activity
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