AURKC and SRPK1

Number of citations of the paper that reports this interaction (PMID 23602568)
8

Data Source:
BioGRID (enzymatic study)

		AURKC	SRPK1
Gene Name		aurora kinase C	SRSF protein kinase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Nuclear Chromosome, Centromeric Region Condensed Chromosome Cytoplasm Spindle Spindle Microtubule Midbody Spindle Pole Centrosome Chromosome Passenger Complex Spindle Midzone	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Plasma Membrane Nuclear Matrix
	Molecular Function	Protein Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity ATP Binding Histone Serine Kinase Activity	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Poly(A) RNA Binding
	Biological Process	Cytokinesis Protein Phosphorylation Attachment Of Spindle Microtubules To Kinetochore Regulation Of Signal Transduction Histone Modification Positive Regulation Of Cytokinesis Histone-serine Phosphorylation Mitotic Spindle Midzone Assembly Meiotic Cell Cycle	MRNA Processing Protein Phosphorylation Chromosome Segregation RNA Splicing Viral Process Sperm Chromatin Condensation Intracellular Signal Transduction Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Innate Immune Response Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: BIRC5 BRCA1 CENPA HIST1H3A INCENP LNX1 NEDD4 NEDD4L SRPK1 TACC2	174 interactors: ADPRH AHCYL1 ALKBH3 AMMECR1L APEX1 APP ARGLU1 ARHGAP12 ARHGAP26 ARL6IP4 ASAH1 ASXL1 AURKA AURKC C11orf52 C11orf63 C11orf87 C16orf78 C18orf25 C9orf72 CACNB1 CAMK2D CBX5 CDC42EP3 CDK7 CDKL3 CHEK2 CHERP CHUK CIAO1 CLIC5 CLK1 CLK4 CRHR1 CSAG1 DAW1 DDX47 DGCR8 DHX8 DHX9 DNAJC8 DUSP6 ECM1 EIF3M EPB41L4A EPHA3 ERBB2 ESRRG FAM124A FAM76B FERMT1 FGF12 FHL1 FKBP3 FLOT1 FLT1 GABARAP GABARAPL1 H2AFY HBS1L HIRIP3 HMGN3 HNRNPA1 IFIT5 IKBKG KCNAB1 KCNN2 KIAA1841 KPNA2 KPTN KRR1 LAMC1 LARP1 LBR LCE3D LIMK1 LINC00312 LUC7L LUC7L2 LUC7L3 MAGEB1 MAOB MAP1LC3A MAPK12 MAPK14 MAPKAPK5 MBNL3 MBP MRPL43 MRPS11 NCK2 NELFE NKAP NOL4L NOP16 NOVA1 NSMCE4A NSRP1 NUDT21 NXT2 OCEL1 ODF3L2 OR6B3 PAK4 PDGFRA PDPK1 PELI1 PELI2 PEX19 PFN1 PHF7 POLR2E PPIA PPIL1 PRM1 PRPF38A PTK2 RBM23 RBM39 RBM8A RBMS2 RIMS4 RNPS1 RPS6KB2 RSRC1 RSRC2 RSRP1 SAFB SCAF11 SEC23B SERPINB10 SETD3 SFMBT1 SLAIN2 SLC4A1AP SNRNP70 SPANXN4 SPATS2 SREK1 SRPK3 SRRM1 SRSF1 SRSF12 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 STAU1 STK26 SUDS3 TAF1B TFEB TNFRSF10C TOP2A TRA2B TRIM65 U2AF1 U2AF2 UBD UBE2E2 USP39 VANGL1 VDR WDR55 YPEL2 YTHDC1 YWHAG ZMYND11 ZNF444 ZNF514 ZRANB2 ZRSR2
Entrez ID		6795	6732
HPRD ID		04605	15992
Ensembl ID		ENSG00000105146	ENSG00000096063
Uniprot IDs		Q5Y191 Q9UQB9	B4DS61 Q96SB4
PDB IDs			1WAK 1WBP 3BEG
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Chromosome Segregation Protein Modification By Small Protein Conjugation Negative Regulation Of Sodium Ion Transport Microtubule Cytoskeleton Organization Cell Cycle Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Transcription, DNA-templated Protein Polyubiquitination Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Viral Process DNA Packaging Regulation Of Potassium Ion Transmembrane Transporter Activity Organelle Organization Negative Regulation Of Gene Expression Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Biosynthetic Process Cell Cycle Protein Monoubiquitination DNA Conformation Change Microtubule-based Process Regulation Of Potassium Ion Transport Regulation Of Sodium Ion Transport Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Histone H4-K20 Methylation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Positive Regulation Of Histone H4-K16 Acetylation Transmission Of Virus Development Involved In Symbiotic Interaction Protein Complex Assembly Organelle Localization Negative Regulation Of Ion Transport Cellular Protein Modification Process Cytoskeleton Organization Positive Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Caveolin-mediated Endocytosis Regulation Of Type B Pancreatic Cell Proliferation Cytokinesis Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Nucleosome Assembly Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Spindle Organization Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process	MRNA Processing RNA Processing RNA Splicing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Gene Expression RNA Metabolic Process DNA-templated Transcription, Termination Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Termination Of RNA Polymerase II Transcription Heterocycle Metabolic Process Cellular Metabolic Process MRNA 3'-end Processing Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Splicing Nitrogen Compound Metabolic Process RNA 3'-end Processing Spliceosomal Complex Assembly RNA Export From Nucleus Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing MRNA Export From Nucleus RNA Localization Nuclear Export MRNA Transport RNA Transport Nucleocytoplasmic Transport Nuclear Transport MRNA Splice Site Selection Ribonucleoprotein Complex Biogenesis Cellular Process Ribonucleoprotein Complex Assembly Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Regulation Of Gene Expression Protein Autophosphorylation Cytoplasmic Transport Regulation Of Alternative MRNA Splicing, Via Spliceosome Posttranscriptional Regulation Of Gene Expression Cellular Component Assembly Transcription, DNA-templated Metabolic Process Cellular Macromolecular Complex Assembly Regulation Of Metabolic Process RNA Biosynthetic Process Protein Phosphorylation Positive Regulation Of Viral Process Regulation Of Nitrogen Compound Metabolic Process
Tagcloud ?		alignment aneuploidy arms attachments aurkb aurora correction cpc generates haploids haspin highlighting implicate improper kinetochore kinetochores meiosis meiotic metaphase mi microtubule mitosis oocytes passenger perturbed phosphorylates prone recruiting segregation	70k arginine asf clk cloning coexpressed contributing dipeptides nh2 pancreas phosphorylate preference preferred proline redistribution reversible rs sf2 similarities spliceosome splicing srpk2 stringent sty u1 uniquely ww
Tagcloud (Difference) ?		alignment aneuploidy arms attachments aurkb aurora correction cpc generates haploids haspin highlighting implicate improper kinetochore kinetochores meiosis meiotic metaphase mi microtubule mitosis oocytes passenger perturbed phosphorylates prone recruiting segregation	70k arginine asf clk cloning coexpressed contributing dipeptides nh2 pancreas phosphorylate preference preferred proline redistribution reversible rs sf2 similarities spliceosome splicing srpk2 stringent sty u1 uniquely ww
Tagcloud (Intersection) ?