OTX2 and TENT5B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		OTX2	TENT5B
Description		orthodenticle homeobox 2	terminal nucleotidyltransferase 5B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Growth Cone Protein-containing Complex	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Eukaryotic Initiation Factor 4E Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Transferase Activity Nucleotidyltransferase Activity Poly(A) RNA Polymerase Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Axon Guidance Regulation Of Smoothened Signaling Pathway Forebrain Development Midbrain Development Positive Regulation Of Embryonic Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Assembly Dopaminergic Neuron Differentiation Primitive Streak Formation Positive Regulation Of Gastrulation	Negative Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Translation Negative Regulation Of Cell Cycle MRNA Stabilization
Pathways		Formation of the anterior neural plate Formation of the posterior neural plate
Drugs
Diseases		Anophthalmia and microphthalmia (A/M) Septo-optic dysplasia
GWAS		Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Chronotype ( 30696823) Lung cancer ( 31577861) Moderate-to-late spontaneous preterm birth ( 31194736) Refractive error ( 32231278)
Interacting Genes		44 interacting genes: APP ASIC4 ATP6V1G3 ATXN1 AURKC B4GALNT2 BNIP2 CDK3 CDK4 DMBX1 EIF4E FOXA2 GPR45 GUCA1B HIKESHI HNF1B HOMER3 HSD3B7 IQGAP1 JPT1 KLF3 LHX1 M1AP MITF NAA50 OR1L3 OR6C1 POLDIP3 RBM47 RNASE11 RPS26 RTCA SMARCB1 SNRPA TBCEL TENT5B TLE4 TMEM11 TNPO2 TRMT10B ZC3H10 ZDHHC17 ZNF765 ZNHIT1	61 interacting genes: ACY1 AKAP8L AKAP9 ATXN1 BHLHE40 C10orf55 C3orf36 CERCAM CIMIP2B CYSRT1 DAZAP2 ENKD1 FAM168B FOS FOSB FOXI1 HIVEP1 HMGXB4 HNRNPF KLHL38 KRT34 KRTAP19-6 KRTAP6-1 KRTAP6-2 MGAT5B MKRN3 NAF1 NICN1 NR1D2 OTX2 PLK4 POU2AF1 POU6F2 PROP1 PSMB8 PSMF1 RBPMS2 RFX6 RHOXF2 RIMBP3C RUSC1 SLC15A2 SLC27A4 SMAP2 SOHLH1 SOX5 SPAG8 TBX6 TENT5A TLE5 TNS2 TRIP13 UBAP2 UBQLN2 USP54 YPEL3 ZBTB2 ZC3H10 ZNF503 ZNF620 ZNF688
Entrez ID		5015	115572
HPRD ID		07190	16882
Ensembl ID		ENSG00000165588	ENSG00000158246
Uniprot IDs		F1T0C9 F1T0D0 F1T0D1 P32243	Q96A09
PDB IDs
Enriched GO Terms of Interacting Partners?		Adult Locomotory Behavior Regulation Of DNA-templated Transcription Initiation Nephric Duct Development Mesonephric Duct Development Positive Regulation Of Gene Expression, Epigenetic Developmental Growth Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Protein Binding Nucleus Transcription Regulator Complex Primitive Streak Formation Positive Regulation Of Gastrulation Pronephros Development Nephric Duct Morphogenesis Developmental Growth Involved In Morphogenesis Nuclear Transport Nucleocytoplasmic Transport Adult Behavior Regulation Of Gastrulation Negative Regulation Of Transcription By RNA Polymerase II	Identical Protein Binding DNA-binding Transcription Factor Activity DNA Binding Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Nucleus Chromatin RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process
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