OTX2 and TRMT10B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		OTX2	TRMT10B
Description		orthodenticle homeobox 2	tRNA methyltransferase 10B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Growth Cone Protein-containing Complex	Nucleus Nucleoplasm Mitochondrial Inner Membrane Cytosol TIM22 Mitochondrial Import Inner Membrane Insertion Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Eukaryotic Initiation Factor 4E Binding Sequence-specific Double-stranded DNA Binding	TRNA Binding Protein Binding Methyltransferase Activity Transferase Activity TRNA (guanosine(9)-N1)-methyltransferase Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Axon Guidance Regulation Of Smoothened Signaling Pathway Forebrain Development Midbrain Development Positive Regulation Of Embryonic Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Assembly Dopaminergic Neuron Differentiation Primitive Streak Formation Positive Regulation Of Gastrulation	TRNA N1-guanine Methylation Methylation Protein Insertion Into Mitochondrial Inner Membrane
Pathways		Formation of the anterior neural plate Formation of the posterior neural plate
Drugs
Diseases		Anophthalmia and microphthalmia (A/M) Septo-optic dysplasia
GWAS		Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Chronotype ( 30696823) Lung cancer ( 31577861) Moderate-to-late spontaneous preterm birth ( 31194736) Refractive error ( 32231278)
Interacting Genes		44 interacting genes: APP ASIC4 ATP6V1G3 ATXN1 AURKC B4GALNT2 BNIP2 CDK3 CDK4 DMBX1 EIF4E FOXA2 GPR45 GUCA1B HIKESHI HNF1B HOMER3 HSD3B7 IQGAP1 JPT1 KLF3 LHX1 M1AP MITF NAA50 OR1L3 OR6C1 POLDIP3 RBM47 RNASE11 RPS26 RTCA SMARCB1 SNRPA TBCEL TENT5B TLE4 TMEM11 TNPO2 TRMT10B ZC3H10 ZDHHC17 ZNF765 ZNHIT1	4 interacting genes: MEIS1 OTX2 TRIM55 TRIM63
Entrez ID		5015	158234
HPRD ID		07190	15242
Ensembl ID		ENSG00000165588	ENSG00000165275
Uniprot IDs		F1T0C9 F1T0D0 F1T0D1 P32243	B7Z9F7 Q6PF06
PDB IDs
Enriched GO Terms of Interacting Partners?		Adult Locomotory Behavior Regulation Of DNA-templated Transcription Initiation Nephric Duct Development Mesonephric Duct Development Positive Regulation Of Gene Expression, Epigenetic Developmental Growth Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Protein Binding Nucleus Transcription Regulator Complex Primitive Streak Formation Positive Regulation Of Gastrulation Pronephros Development Nephric Duct Morphogenesis Developmental Growth Involved In Morphogenesis Nuclear Transport Nucleocytoplasmic Transport Adult Behavior Regulation Of Gastrulation Negative Regulation Of Transcription By RNA Polymerase II	Cell Growth Involved In Cardiac Muscle Cell Development Lens Morphogenesis In Camera-type Eye Primitive Streak Formation Eukaryotic Initiation Factor 4E Binding Positive Regulation Of Gastrulation Regulation Of Gastrulation Ubiquitin Protein Ligase Activity Microtubule Diapedesis Muscle Atrophy Titin Binding Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Skeletal Muscle Atrophy Skeletal Muscle Adaptation Contractile Muscle Fiber Striated Muscle Atrophy Definitive Hemopoiesis DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Embryonic Development Leukocyte Migration Involved In Inflammatory Response Negative Regulation Of Glycolytic Process Megakaryocyte Development Macrophage Migration M Band Negative Regulation Of ATP Metabolic Process
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