OTX2 and ASIC4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		OTX2	ASIC4
Description		orthodenticle homeobox 2	acid sensing ion channel subunit family member 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Growth Cone Protein-containing Complex	Plasma Membrane Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Eukaryotic Initiation Factor 4E Binding Sequence-specific Double-stranded DNA Binding	Sodium Channel Activity Protein Binding Ligand-gated Sodium Channel Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Axon Guidance Regulation Of Smoothened Signaling Pathway Forebrain Development Midbrain Development Positive Regulation Of Embryonic Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Assembly Dopaminergic Neuron Differentiation Primitive Streak Formation Positive Regulation Of Gastrulation	Behavioral Fear Response Monoatomic Ion Transport Sodium Ion Transport Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport
Pathways		Formation of the anterior neural plate Formation of the posterior neural plate	Stimuli-sensing channels
Drugs
Diseases		Anophthalmia and microphthalmia (A/M) Septo-optic dysplasia
GWAS		Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Chronotype ( 30696823) Lung cancer ( 31577861) Moderate-to-late spontaneous preterm birth ( 31194736) Refractive error ( 32231278)	Cerebrospinal fluid sTREM-2 levels ( 31708768) Lung function (FVC) ( 30804560)
Interacting Genes		44 interacting genes: APP ASIC4 ATP6V1G3 ATXN1 AURKC B4GALNT2 BNIP2 CDK3 CDK4 DMBX1 EIF4E FOXA2 GPR45 GUCA1B HIKESHI HNF1B HOMER3 HSD3B7 IQGAP1 JPT1 KLF3 LHX1 M1AP MITF NAA50 OR1L3 OR6C1 POLDIP3 RBM47 RNASE11 RPS26 RTCA SMARCB1 SNRPA TBCEL TENT5B TLE4 TMEM11 TNPO2 TRMT10B ZC3H10 ZDHHC17 ZNF765 ZNHIT1	3 interacting genes: CFTR OTX2 ZDHHC17
Entrez ID		5015	55515
HPRD ID		07190	16231
Ensembl ID		ENSG00000165588	ENSG00000072182
Uniprot IDs		F1T0C9 F1T0D0 F1T0D1 P32243	A0A8I5KPF5 Q96FT7
PDB IDs
Enriched GO Terms of Interacting Partners?		Adult Locomotory Behavior Regulation Of DNA-templated Transcription Initiation Nephric Duct Development Mesonephric Duct Development Positive Regulation Of Gene Expression, Epigenetic Developmental Growth Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Protein Binding Nucleus Transcription Regulator Complex Primitive Streak Formation Positive Regulation Of Gastrulation Pronephros Development Nephric Duct Morphogenesis Developmental Growth Involved In Morphogenesis Nuclear Transport Nucleocytoplasmic Transport Adult Behavior Regulation Of Gastrulation Negative Regulation Of Transcription By RNA Polymerase II	Golgi-associated Vesicle Membrane Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Interleukin-17-mediated Signaling Pathway Actin Ubiquitination Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production Perforant Pathway To Dendrate Granule Cell Synapse Positive Regulation Of Anion Channel Activity Protein Localization To Phagocytic Vesicle Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Positive Regulation Of Monoatomic Anion Transport Striated Muscle Myosin Thick Filament Positive Regulation Of Enamel Mineralization Actin Modification Cell Projection Organization Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Cell Communication Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Signaling Regulation Of Enamel Mineralization Membrane Hyperpolarization Positive Regulation Of Gastrulation Free Ubiquitin Chain Polymerization Cytosolic Ciliogenesis Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-stearoyltransferase Activity Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Developmental Process Eukaryotic Initiation Factor 4E Binding Regulation Of Multicellular Organismal Development Amelogenesis Regulation Of Canonical NF-kappaB Signal Transduction ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Cellular Response To Growth Factor Stimulus Tat Protein Binding Primitive Streak Formation Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Regulation Of Gastrulation Cellular Response To Forskolin Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Cell Communication Chloride Transmembrane Transporter Activity
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