OTX2 and NAA50

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		OTX2	NAA50
Description		orthodenticle homeobox 2	N-alpha-acetyltransferase 50, NatE catalytic subunit
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Growth Cone Protein-containing Complex	Nucleus Nucleolus Cytoplasm Cytosol NatA Complex Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Eukaryotic Initiation Factor 4E Binding Sequence-specific Double-stranded DNA Binding	Protein-N-terminal Amino-acid Acetyltransferase Activity Protein Binding Histone H4 Acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Protein-lysine-acetyltransferase Activity Protein N-terminal-methionine Acetyltransferase Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Axon Guidance Regulation Of Smoothened Signaling Pathway Forebrain Development Midbrain Development Positive Regulation Of Embryonic Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Assembly Dopaminergic Neuron Differentiation Primitive Streak Formation Positive Regulation Of Gastrulation	Chromatin Remodeling N-terminal Protein Amino Acid Acetylation Mitotic Sister Chromatid Cohesion Establishment Of Mitotic Sister Chromatid Cohesion Post-translational Protein Modification Mitotic Sister Chromatid Cohesion, Centromeric
Pathways		Formation of the anterior neural plate Formation of the posterior neural plate
Drugs
Diseases		Anophthalmia and microphthalmia (A/M) Septo-optic dysplasia
GWAS		Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Chronotype ( 30696823) Lung cancer ( 31577861) Moderate-to-late spontaneous preterm birth ( 31194736) Refractive error ( 32231278)	Prostate cancer ( 23535732)
Interacting Genes		44 interacting genes: APP ASIC4 ATP6V1G3 ATXN1 AURKC B4GALNT2 BNIP2 CDK3 CDK4 DMBX1 EIF4E FOXA2 GPR45 GUCA1B HIKESHI HNF1B HOMER3 HSD3B7 IQGAP1 JPT1 KLF3 LHX1 M1AP MITF NAA50 OR1L3 OR6C1 POLDIP3 RBM47 RNASE11 RPS26 RTCA SMARCB1 SNRPA TBCEL TENT5B TLE4 TMEM11 TNPO2 TRMT10B ZC3H10 ZDHHC17 ZNF765 ZNHIT1	6 interacting genes: BHLHE40 CEBPA JMJD6 NAA10 NAA15 OTX2
Entrez ID		5015	80218
HPRD ID		07190	14350
Ensembl ID		ENSG00000165588	ENSG00000121579
Uniprot IDs		F1T0C9 F1T0D0 F1T0D1 P32243	E7EQ69 Q9GZZ1
PDB IDs			2OB0 2PSW 3TFY 4X5K 6PPL 6PW9 6WF3 6WF5 6WFG 6WFK 6WFN 6WFO 9F1B 9F1C 9F1D
Enriched GO Terms of Interacting Partners?		Adult Locomotory Behavior Regulation Of DNA-templated Transcription Initiation Nephric Duct Development Mesonephric Duct Development Positive Regulation Of Gene Expression, Epigenetic Developmental Growth Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Protein Binding Nucleus Transcription Regulator Complex Primitive Streak Formation Positive Regulation Of Gastrulation Pronephros Development Nephric Duct Morphogenesis Developmental Growth Involved In Morphogenesis Nuclear Transport Nucleocytoplasmic Transport Adult Behavior Regulation Of Gastrulation Negative Regulation Of Transcription By RNA Polymerase II	NatA Complex Lung Development N-terminal Protein Amino Acid Acetylation Acetyltransferase Activity Protein Acetylation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Ribosome Binding Histone H4R3 Demethylase Activity Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Peptidyl-lysine 5-dioxygenase Activity Histone H3R2 Demethylase Activity Oxidative RNA Demethylation Determination Of Stomach Left/right Asymmetry Determination Of Intestine Left/right Asymmetry Response To Vitamin B2 C/EBP Complex Protein-N-terminal-alanine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity CHOP-C/EBP Complex Protein N-terminal-serine Acetyltransferase Activity Negative Regulation Of Protein Homooligomerization Ciliary Inversin Compartment White Fat Cell Proliferation Oxidative RNA Demethylase Activity Protein Demethylase Activity P-TEFb Complex Binding Negative Regulation Of Protein Oligomerization Maintenance Of Animal Organ Identity DNA-binding Transcription Factor Activity Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Regulation Of Centromeric Sister Chromatid Cohesion Negative Regulation Of Sister Chromatid Cohesion MRF Binding Kidney Development Determination Of Pancreatic Left/right Asymmetry Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Protein-N-terminal Amino-acid Acetyltransferase Activity Recognition Of Apoptotic Cell Convergent Extension Involved In Gastrulation Determination Of Liver Left/right Asymmetry RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of DNA-templated Transcription Response To Phenylpropanoid Regulation Of RNA Biosynthetic Process Fat Cell Proliferation Eukaryotic Initiation Factor 4E Binding Anatomical Structure Formation Involved In Morphogenesis
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