OTX2 and FOXA2

Number of citations of the paper that reports this interaction (PubMedID 10623575)
0

Data Source:
HPRD (in vitro)

		OTX2	FOXA2
Description		orthodenticle homeobox 2	forkhead box A2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Growth Cone Protein-containing Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cell Junction
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Eukaryotic Initiation Factor 4E Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleic Acid Binding DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Axon Guidance Regulation Of Smoothened Signaling Pathway Forebrain Development Midbrain Development Positive Regulation Of Embryonic Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Assembly Dopaminergic Neuron Differentiation Primitive Streak Formation Positive Regulation Of Gastrulation	Negative Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Adult Locomotory Behavior Anatomical Structure Morphogenesis Negative Regulation Of Epithelial To Mesenchymal Transition Cell Differentiation Regulation Of Blood Coagulation Endocrine Pancreas Development Positive Regulation Of Embryonic Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Response To Interleukin-6 Dopaminergic Neuron Differentiation Primitive Streak Formation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Gastrulation
Pathways		Formation of the anterior neural plate Formation of the posterior neural plate	Regulation of gene expression in beta cells Positive Regulation of CDH1 Gene Transcription Formation of axial mesoderm Formation of definitive endoderm Developmental Lineage of Pancreatic Acinar Cells Developmental Lineage of Pancreatic Ductal Cells Developmental Lineage of Multipotent Pancreatic Progenitor Cells
Drugs
Diseases		Anophthalmia and microphthalmia (A/M) Septo-optic dysplasia
GWAS		Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Chronotype ( 30696823) Lung cancer ( 31577861) Moderate-to-late spontaneous preterm birth ( 31194736) Refractive error ( 32231278)	Adolescent idiopathic scoliosis ( 25784220) Apolipoprotein A1 levels ( 32203549) Birth weight ( 31043758) Body size at age 10 ( 32376654) Fasting blood glucose ( 22581228 33842983) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 34059833) Fasting plasma glucose ( 20152958 25187374) Gout ( 22179738) Hypothyroidism ( 27182965) Male-pattern baldness ( 27182965 22693459) Monobrow ( 27182965) Type 2 diabetes ( 30054458 32499647) Vitamin D levels ( 26704534)
Interacting Genes		44 interacting genes: APP ASIC4 ATP6V1G3 ATXN1 AURKC B4GALNT2 BNIP2 CDK3 CDK4 DMBX1 EIF4E FOXA2 GPR45 GUCA1B HIKESHI HNF1B HOMER3 HSD3B7 IQGAP1 JPT1 KLF3 LHX1 M1AP MITF NAA50 OR1L3 OR6C1 POLDIP3 RBM47 RNASE11 RPS26 RTCA SMARCB1 SNRPA TBCEL TENT5B TLE4 TMEM11 TNPO2 TRMT10B ZC3H10 ZDHHC17 ZNF765 ZNHIT1	10 interacting genes: EN2 GSC HOXA5 LHX1 MIP NCOA1 ONECUT1 OTUD3 OTX2 TLE1
Entrez ID		5015	3170
HPRD ID		07190	02618
Ensembl ID		ENSG00000165588	ENSG00000125798
Uniprot IDs		F1T0C9 F1T0D0 F1T0D1 P32243	B0ZTD4 Q9Y261
PDB IDs			5X07 7YZE 7YZF
Enriched GO Terms of Interacting Partners?		Adult Locomotory Behavior Regulation Of DNA-templated Transcription Initiation Nephric Duct Development Mesonephric Duct Development Positive Regulation Of Gene Expression, Epigenetic Developmental Growth Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Protein Binding Nucleus Transcription Regulator Complex Primitive Streak Formation Positive Regulation Of Gastrulation Pronephros Development Nephric Duct Morphogenesis Developmental Growth Involved In Morphogenesis Nuclear Transport Nucleocytoplasmic Transport Adult Behavior Regulation Of Gastrulation Negative Regulation Of Transcription By RNA Polymerase II	Sequence-specific Double-stranded DNA Binding Chromatin Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gastrulation Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Primitive Streak Formation Regulation Of Gastrulation Neuron Differentiation DNA Binding Animal Organ Development Positive Regulation Of Embryonic Development Regulation Of Gene Expression Anatomical Structure Morphogenesis Embryonic Morphogenesis DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Developmental Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process Midbrain Development Dopaminergic Neuron Differentiation Endoderm Development Animal Organ Morphogenesis Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Gastrulation Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Cerebellum Development Regionalization Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Tissue Development Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Dorsal Spinal Cord Interneuron Posterior Axon Guidance Nephric Duct Elongation Ectoderm Formation Metanephric Renal Vesicle Morphogenesis Renal Vesicle Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter By Galactose
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