OTX2 and FOXA2

Number of citations of the paper that reports this interaction (PMID 10623575)
9

Data Source:
HPRD (in vitro)

		OTX2	FOXA2
Gene Name		orthodenticle homeobox 2	forkhead box A2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Growth Cone Protein Complex	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Binding Eukaryotic Initiation Factor 4E Binding Protein Heterodimerization Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Factor Binding Protein Domain Specific Binding Transcription Regulatory Region DNA Binding
	Biological Process	Cell Fate Specification Protein Complex Assembly Axon Guidance Endoderm Development Regulation Of Smoothened Signaling Pathway Dorsal/ventral Pattern Formation Metencephalon Development Forebrain Development Midbrain Development Somite Rostral/caudal Axis Specification Positive Regulation Of Embryonic Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Inner Ear Morphogenesis Eye Photoreceptor Cell Fate Commitment Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neuron Fate Determination Diencephalon Morphogenesis Primitive Streak Formation Positive Regulation Of Gastrulation	Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Negative Regulation Of Transcription From RNA Polymerase II Promoter By Glucose In Utero Embryonic Development Ectoderm Formation Cell Fate Specification Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Adult Locomotory Behavior Negative Regulation Of Epithelial To Mesenchymal Transition Chromatin Modification Regulation Of Steroid Metabolic Process Cell Differentiation In Hindbrain Dorsal/ventral Neural Tube Patterning Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Blood Coagulation Endocrine Pancreas Development Somite Rostral/caudal Axis Specification Negative Regulation Of Glucokinase Activity Positive Regulation Of Embryonic Development Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase III Promoter Cell Development Neuron Fate Specification Epithelial Tube Branching Involved In Lung Morphogenesis Lung Epithelial Cell Differentiation Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Connective Tissue Development Response To Interleukin-6 Dopaminergic Neuron Differentiation Primitive Streak Formation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Gastrulation Negative Regulation Of Detection Of Glucose
Pathways			Regulation of beta-cell development Regulation of gene expression in beta cells
Drugs
Diseases
GWAS			Fasting glucose-related traits (interaction with BMI) ( 22581228) Fasting plasma glucose ( 20152958) Male-pattern baldness ( 22693459)
Protein-Protein Interactions		9 interactors: APP ATXN1 CDK4 DMBX1 FOXA2 LHX1 MITF TLE4 ZDHHC17	9 interactors: EN2 GSC HOXA5 LHX1 MIP NCOA1 ONECUT1 OTX2 TLE1
Entrez ID		5015	3170
HPRD ID		07190	02618
Ensembl ID		ENSG00000165588	ENSG00000125798
Uniprot IDs		F1T0C9 F1T0D0 F1T0D1 P32243	B0ZTD4 Q9Y261
PDB IDs
Enriched GO Terms of Interacting Partners?		Adult Locomotory Behavior Ectoderm Formation Adult Behavior Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Locomotory Behavior Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gastrulation Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Primitive Streak Formation Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Somite Rostral/caudal Axis Specification Single-organism Behavior RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Ectoderm Development Gene Expression Behavior Cellular Macromolecule Biosynthetic Process Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Cell Differentiation In Hindbrain Macromolecule Biosynthetic Process Positive Regulation Of Embryonic Development RNA Biosynthetic Process Signaling Regulation Of Gastrulation Cell Communication Positive Regulation Of Cellular Metabolic Process Brain Development Regulation Of G2/M Transition Of Mitotic Cell Cycle Developmental Growth System Development Regulation Of Cell Cycle G2/M Phase Transition Head Development Regulation Of Transcription, DNA-templated Embryonic Axis Specification Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Transcription From RNA Polymerase II Promoter Gastrulation With Mouth Forming Second	Organ Development Positive Regulation Of Gene Expression System Development Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Hindbrain Development Embryonic Organ Development Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Regulation Of Gene Expression Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Embryonic Morphogenesis Developmental Process Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Anatomical Structure Morphogenesis Endoderm Development Embryonic Organ Morphogenesis Brain Development Chordate Embryonic Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gastrulation Embryo Development Ending In Birth Or Egg Hatching Head Development Positive Regulation Of Cellular Biosynthetic Process Primitive Streak Formation Dorsal/ventral Pattern Formation Embryonic Skeletal System Morphogenesis Metencephalon Development Central Nervous System Development Somite Rostral/caudal Axis Specification Cell Development Forebrain Development Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Pattern Specification Process Epithelium Development RNA Metabolic Process Embryonic Skeletal System Development Embryo Development Regulation Of Metabolic Process Cell Differentiation Positive Regulation Of Metabolic Process Gene Expression Gastrulation
Tagcloud ?		accumulate anatomical argue arise assertions atavism cartilages chondrify claim condensation disrupted disruptions dlx evolutionary hoxa hypotheses investigators jaw knockout mesenchyme mhox migrate morphogenesis played primitive reversals reversion specification sufficiently	acetylated battery brachyury confocal deta differentiating directed disrupting endoderm express flk1 gata4 matter mef2c mesc mesendoderm mesoderm mesodermal nanog occupancy oct4 pluripotency protocols reexpressed reexpression repression resp simultaneously undergoing
Tagcloud (Difference) ?		accumulate anatomical argue arise assertions atavism cartilages chondrify claim condensation disrupted disruptions dlx evolutionary hoxa hypotheses investigators jaw knockout mesenchyme mhox migrate morphogenesis played primitive reversals reversion specification sufficiently	acetylated battery brachyury confocal deta differentiating directed disrupting endoderm express flk1 gata4 matter mef2c mesc mesendoderm mesoderm mesodermal nanog occupancy oct4 pluripotency protocols reexpressed reexpression repression resp simultaneously undergoing
Tagcloud (Intersection) ?