AURKC and INCENP

Number of citations of the paper that reports this interaction (PMID 15316025)
22

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		AURKC	INCENP
Gene Name		aurora kinase C	inner centromere protein antigens 135/155kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Nuclear Chromosome, Centromeric Region Condensed Chromosome Cytoplasm Spindle Spindle Microtubule Midbody Spindle Pole Centrosome Chromosome Passenger Complex Spindle Midzone	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Lateral Element Central Element Pericentric Heterochromatin Spindle Cytosol Microtubule Chromocenter Midbody Protein Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity ATP Binding Histone Serine Kinase Activity	Protein Binding
	Biological Process	Cytokinesis Protein Phosphorylation Attachment Of Spindle Microtubules To Kinetochore Regulation Of Signal Transduction Histone Modification Positive Regulation Of Cytokinesis Histone-serine Phosphorylation Mitotic Spindle Midzone Assembly Meiotic Cell Cycle	Mitotic Cell Cycle Cytokinesis Chromosome Segregation Mitotic Nuclear Division
Pathways			Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS			Phospholipid levels (plasma) ( 21829377)
Protein-Protein Interactions		10 interactors: BIRC5 BRCA1 CENPA HIST1H3A INCENP LNX1 NEDD4 NEDD4L SRPK1 TACC2	10 interactors: AURKA AURKB AURKC BIRC5 CBX5 CDCA8 EVI5 FLOT1 H2AFZ HIST2H3C
Entrez ID		6795	3619
HPRD ID		04605	05103
Ensembl ID		ENSG00000105146	ENSG00000149503
Uniprot IDs		Q5Y191 Q9UQB9	Q9NQS7
PDB IDs			2QFA 4AF3
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Chromosome Segregation Protein Modification By Small Protein Conjugation Negative Regulation Of Sodium Ion Transport Microtubule Cytoskeleton Organization Cell Cycle Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Transcription, DNA-templated Protein Polyubiquitination Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Viral Process DNA Packaging Regulation Of Potassium Ion Transmembrane Transporter Activity Organelle Organization Negative Regulation Of Gene Expression Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Biosynthetic Process Cell Cycle Protein Monoubiquitination DNA Conformation Change Microtubule-based Process Regulation Of Potassium Ion Transport Regulation Of Sodium Ion Transport Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Histone H4-K20 Methylation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Positive Regulation Of Histone H4-K16 Acetylation Transmission Of Virus Development Involved In Symbiotic Interaction Protein Complex Assembly Organelle Localization Negative Regulation Of Ion Transport Cellular Protein Modification Process Cytoskeleton Organization Positive Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Caveolin-mediated Endocytosis Regulation Of Type B Pancreatic Cell Proliferation Cytokinesis Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Nucleosome Assembly Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Spindle Organization Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process	Mitotic Spindle Organization Cell Division Histone-serine Phosphorylation Spindle Assembly Mitotic Spindle Assembly Mitotic Nuclear Division Positive Regulation Of Cell Division Spindle Organization Histone Phosphorylation Spindle Stabilization Regulation Of Cytokinesis Positive Regulation Of Cell Cycle Process Chromosome Segregation Regulation Of Cell Division Mitotic Spindle Midzone Assembly Mitotic Spindle Elongation Positive Regulation Of Cell Cycle Mitotic Cell Cycle Process Cell Cycle Mitotic Cell Cycle Spindle Midzone Assembly Attachment Of Spindle Microtubules To Kinetochore Cellular Localization Cytokinesis Peptidyl-serine Phosphorylation Microtubule Cytoskeleton Organization Organelle Assembly Regulation Of Cell Cycle Process Cell Cycle Process Positive Regulation Of Cytokinesis Negative Regulation Of Microtubule Depolymerization Positive Regulation Of Mitotic Nuclear Division Spindle Checkpoint Establishment Of Chromosome Localization Negative Regulation Of Microtubule Polymerization Or Depolymerization Microtubule-based Process Negative Regulation Of Protein Binding Microtubule Anchoring Regulation Of Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Spindle Checkpoint Histone Modification Chromosome Organization Organelle Localization Protein Complex Assembly Protein Localization Negative Regulation Of Protein Complex Disassembly Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Binding
Tagcloud ?		alignment aneuploidy arms attachments aurkb aurora correction cpc generates haploids haspin highlighting implicate improper kinetochore kinetochores meiosis meiotic metaphase mi microtubule mitosis oocytes passenger perturbed phosphorylates prone recruiting segregation	allele aurkb birc5 cdca8 consortium contribution cpc division european exon familial fifteen fixed genotyped inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability
Tagcloud (Difference) ?		alignment aneuploidy arms attachments aurora correction generates haploids haspin highlighting implicate improper kinetochore kinetochores meiosis meiotic metaphase mi microtubule mitosis oocytes perturbed phosphorylates prone recruiting segregation	allele birc5 cdca8 consortium contribution division european exon familial fifteen fixed genotyped inherited investigates meta modest pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability
Tagcloud (Intersection) ?		aurkb cpc passenger