OTX2

Gene Name		orthodenticle homeobox 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Growth Cone Protein Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Binding Eukaryotic Initiation Factor 4E Binding Protein Heterodimerization Activity
	Biological Process	Cell Fate Specification Protein Complex Assembly Axon Guidance Endoderm Development Regulation Of Smoothened Signaling Pathway Dorsal/ventral Pattern Formation Metencephalon Development Forebrain Development Midbrain Development Somite Rostral/caudal Axis Specification Positive Regulation Of Embryonic Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Inner Ear Morphogenesis Eye Photoreceptor Cell Fate Commitment Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neuron Fate Determination Diencephalon Morphogenesis Primitive Streak Formation Positive Regulation Of Gastrulation
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		9 interactors: APP ATXN1 CDK4 DMBX1 FOXA2 LHX1 MITF TLE4 ZDHHC17
Entrez ID		5015
HPRD ID		07190
Ensembl ID		ENSG00000165588
Uniprot IDs		F1T0C9 F1T0D0 F1T0D1 P32243
PDB IDs
Enriched GO Terms of Interacting Partners?		Adult Locomotory Behavior Ectoderm Formation Adult Behavior Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Locomotory Behavior Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gastrulation Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Primitive Streak Formation Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Somite Rostral/caudal Axis Specification Single-organism Behavior RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Ectoderm Development Gene Expression Behavior Cellular Macromolecule Biosynthetic Process Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Cell Differentiation In Hindbrain Macromolecule Biosynthetic Process Positive Regulation Of Embryonic Development RNA Biosynthetic Process Signaling Regulation Of Gastrulation Cell Communication Positive Regulation Of Cellular Metabolic Process Brain Development Regulation Of G2/M Transition Of Mitotic Cell Cycle Developmental Growth System Development Regulation Of Cell Cycle G2/M Phase Transition Head Development Regulation Of Transcription, DNA-templated Embryonic Axis Specification Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Transcription From RNA Polymerase II Promoter Gastrulation With Mouth Forming Second
Tagcloud ?		accumulate anatomical argue arise assertions atavism cartilages chondrify claim condensation disrupted disruptions dlx evolutionary hoxa hypotheses investigators jaw knockout mesenchyme mhox migrate morphogenesis played primitive reversals reversion specification sufficiently