AURKC and CENPA

Number of citations of the paper that reports this interaction (PMID 20663916)
17

Data Source:
BioGRID (enzymatic study)

		AURKC	CENPA
Gene Name		aurora kinase C	centromere protein A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Nuclear Chromosome, Centromeric Region Condensed Chromosome Cytoplasm Spindle Spindle Microtubule Midbody Spindle Pole Centrosome Chromosome Passenger Complex Spindle Midzone	Chromosome, Centromeric Region Condensed Nuclear Chromosome Kinetochore Condensed Nuclear Chromosome, Centromeric Region Nucleosome Condensed Chromosome Inner Kinetochore Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity ATP Binding Histone Serine Kinase Activity	DNA Binding Chromatin Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Cytokinesis Protein Phosphorylation Attachment Of Spindle Microtubules To Kinetochore Regulation Of Signal Transduction Histone Modification Positive Regulation Of Cytokinesis Histone-serine Phosphorylation Mitotic Spindle Midzone Assembly Meiotic Cell Cycle	Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Nucleosome Assembly Viral Process CENP-A Containing Nucleosome Assembly Kinetochore Assembly Protein Localization To Chromosome, Centromeric Region
Pathways			Mitotic Prometaphase Chromosome Maintenance Nucleosome assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: BIRC5 BRCA1 CENPA HIST1H3A INCENP LNX1 NEDD4 NEDD4L SRPK1 TACC2	8 interactors: AURKB AURKC DIAPH1 DIAPH2 HIST1H3C HIST1H4F PARP1 PARP2
Entrez ID		6795	1058
HPRD ID		04605	00313
Ensembl ID		ENSG00000105146	ENSG00000115163
Uniprot IDs		Q5Y191 Q9UQB9	P49450
PDB IDs			3AN2 3NQJ 3NQU 3R45
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Chromosome Segregation Protein Modification By Small Protein Conjugation Negative Regulation Of Sodium Ion Transport Microtubule Cytoskeleton Organization Cell Cycle Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Transcription, DNA-templated Protein Polyubiquitination Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Viral Process DNA Packaging Regulation Of Potassium Ion Transmembrane Transporter Activity Organelle Organization Negative Regulation Of Gene Expression Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Biosynthetic Process Cell Cycle Protein Monoubiquitination DNA Conformation Change Microtubule-based Process Regulation Of Potassium Ion Transport Regulation Of Sodium Ion Transport Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Histone H4-K20 Methylation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Positive Regulation Of Histone H4-K16 Acetylation Transmission Of Virus Development Involved In Symbiotic Interaction Protein Complex Assembly Organelle Localization Negative Regulation Of Ion Transport Cellular Protein Modification Process Cytoskeleton Organization Positive Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Caveolin-mediated Endocytosis Regulation Of Type B Pancreatic Cell Proliferation Cytokinesis Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Nucleosome Assembly Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Spindle Organization Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process	Cellular Macromolecular Complex Assembly Protein Complex Assembly Mitotic Spindle Midzone Assembly Mitotic Spindle Elongation Cellular Protein Complex Assembly DNA Replication-dependent Nucleosome Assembly Spindle Midzone Assembly Cytokinesis Attachment Of Spindle Microtubules To Kinetochore Organelle Organization Cellular Component Assembly DNA Methylation On Cytosine Chromosome Organization Chromatin Silencing At RDNA Histone-serine Phosphorylation Mitotic Spindle Assembly Protein ADP-ribosylation Chromatin Organization Chromatin Silencing Positive Regulation Of Cytokinesis Histone Phosphorylation Actin Filament Polymerization Mitotic Spindle Organization Regulation Of Cytokinesis Microtubule Anchoring DNA Methylation Base-excision Repair Histone Modification DNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression, Epigenetic Telomere Maintenance Cytoskeleton Organization Cell Division Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Actin Polymerization Or Depolymerization Spindle Assembly DNA Modification Protein Polymerization Gene Silencing Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cell Cycle Peptidyl-serine Phosphorylation Nucleosome Assembly Positive Regulation Of Cell Division Spindle Organization Chromatin Modification Chromatin Assembly
Tagcloud ?		alignment aneuploidy arms attachments aurkb aurora correction cpc generates haploids haspin highlighting implicate improper kinetochore kinetochores meiosis meiotic metaphase mi microtubule mitosis oocytes passenger perturbed phosphorylates prone recruiting segregation	annotated bca centromere chromosomes commercially consequent dfs division embedded evaluating exploration hallmark hazards ihc instability kaplan km mammaprint meier mgism microarrays nuclei paraffin scored segregation signature stained triplicate visibly
Tagcloud (Difference) ?		alignment aneuploidy arms attachments aurkb aurora correction cpc generates haploids haspin highlighting implicate improper kinetochore kinetochores meiosis meiotic metaphase mi microtubule mitosis oocytes passenger perturbed phosphorylates prone recruiting	annotated bca centromere chromosomes commercially consequent dfs division embedded evaluating exploration hallmark hazards ihc instability kaplan km mammaprint meier mgism microarrays nuclei paraffin scored signature stained triplicate visibly
Tagcloud (Intersection) ?		segregation