AURKC and BIRC5

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		AURKC	BIRC5
Gene Name		aurora kinase C	baculoviral IAP repeat containing 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Nuclear Chromosome, Centromeric Region Condensed Chromosome Cytoplasm Spindle Spindle Microtubule Midbody Spindle Pole Centrosome Chromosome Passenger Complex Spindle Midzone	Nuclear Chromosome Chromosome, Centromeric Region Condensed Chromosome Kinetochore Nucleus Cytoplasm Centriole Spindle Cytosol Microtubule Spindle Microtubule Cytoplasmic Microtubule Midbody Interphase Microtubule Organizing Center Chromosome Passenger Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity ATP Binding Histone Serine Kinase Activity	Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Microtubule Binding Zinc Ion Binding Ran GTPase Binding Tubulin Binding Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Protein Heterodimerization Activity Cofactor Binding Cobalt Ion Binding Chaperone Binding
	Biological Process	Cytokinesis Protein Phosphorylation Attachment Of Spindle Microtubules To Kinetochore Regulation Of Signal Transduction Histone Modification Positive Regulation Of Cytokinesis Histone-serine Phosphorylation Mitotic Spindle Midzone Assembly Meiotic Cell Cycle	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Cytokinesis Transcription, DNA-templated Protein Phosphorylation Chromosome Segregation Mitotic Nuclear Division Positive Regulation Of Cell Proliferation Regulation Of Signal Transduction Protein Ubiquitination Protein Complex Localization Positive Regulation Of Exit From Mitosis Spindle Checkpoint Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle Cell Division Establishment Of Chromosome Localization Mitotic Spindle Assembly Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Pathways			Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS			Blood trace element (Se levels) ( 23720494)
Protein-Protein Interactions		10 interactors: BIRC5 BRCA1 CENPA HIST1H3A INCENP LNX1 NEDD4 NEDD4L SRPK1 TACC2	22 interactors: AURKA AURKB AURKC BIRC2 BIRC3 BIRC6 CASP3 CASP7 CASP9 CDCA8 CDK1 CDK4 DIABLO EVI5 HIST2H3C HIST3H3 HSP90AA1 INCENP KCNJ6 RASA1 XIAP XPO1
Entrez ID		6795	332
HPRD ID		04605	04520
Ensembl ID		ENSG00000105146	ENSG00000089685
Uniprot IDs		Q5Y191 Q9UQB9	H3BLT4 O15392
PDB IDs			1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Chromosome Segregation Protein Modification By Small Protein Conjugation Negative Regulation Of Sodium Ion Transport Microtubule Cytoskeleton Organization Cell Cycle Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Transcription, DNA-templated Protein Polyubiquitination Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Viral Process DNA Packaging Regulation Of Potassium Ion Transmembrane Transporter Activity Organelle Organization Negative Regulation Of Gene Expression Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Biosynthetic Process Cell Cycle Protein Monoubiquitination DNA Conformation Change Microtubule-based Process Regulation Of Potassium Ion Transport Regulation Of Sodium Ion Transport Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Histone H4-K20 Methylation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Positive Regulation Of Histone H4-K16 Acetylation Transmission Of Virus Development Involved In Symbiotic Interaction Protein Complex Assembly Organelle Localization Negative Regulation Of Ion Transport Cellular Protein Modification Process Cytoskeleton Organization Positive Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Caveolin-mediated Endocytosis Regulation Of Type B Pancreatic Cell Proliferation Cytokinesis Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Nucleosome Assembly Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Spindle Organization Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process	Cell Division Mitotic Cell Cycle Regulation Of Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Regulation Of Cell Death Regulation Of Proteolysis Mitotic Cell Cycle Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Cycle Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Mitotic Nuclear Division Cell Cycle Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Histone Phosphorylation Positive Regulation Of Protein Metabolic Process Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Cell Cycle Negative Regulation Of Programmed Cell Death Apoptotic Process Regulation Of Protein Metabolic Process Negative Regulation Of Cell Death Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Programmed Cell Death Cell Death Death Regulation Of Cytokinesis Histone-serine Phosphorylation Positive Regulation Of Proteolysis Regulation Of Cellular Protein Metabolic Process Intrinsic Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Metabolic Process Zymogen Activation Cytokinesis Peptidyl-serine Phosphorylation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cell Cycle Process Positive Regulation Of Cysteine-type Endopeptidase Activity Spindle Stabilization Positive Regulation Of Cell Cycle Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Endopeptidase Activity Mitotic Spindle Organization Positive Regulation Of Protein Ubiquitination Positive Regulation Of Peptidase Activity
Tagcloud ?		alignment aneuploidy arms attachments aurkb aurora correction cpc generates haploids haspin highlighting implicate improper kinetochore kinetochores meiosis meiotic metaphase mi microtubule mitosis oocytes passenger perturbed phosphorylates prone recruiting segregation	autophagy bcl2 buffer constituents damaged dataset degrades deregulation distant eif4ebp1 ero1l fos gapdh gse21653 gse3494 gse7390 inc itpr1 lived organelles periodicals prognostic proportional shortened signature starvation subgroups vegfa wiley
Tagcloud (Difference) ?		alignment aneuploidy arms attachments aurkb aurora correction cpc generates haploids haspin highlighting implicate improper kinetochore kinetochores meiosis meiotic metaphase mi microtubule mitosis oocytes passenger perturbed phosphorylates prone recruiting segregation	autophagy bcl2 buffer constituents damaged dataset degrades deregulation distant eif4ebp1 ero1l fos gapdh gse21653 gse3494 gse7390 inc itpr1 lived organelles periodicals prognostic proportional shortened signature starvation subgroups vegfa wiley
Tagcloud (Intersection) ?