LGALS13 and ANXA2

Number of citations of the paper that reports this interaction (PubMedID 15009185)
0

Data Source:
HPRD (in vitro)

		LGALS13	ANXA2
Description		galectin 13	annexin A2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Nuclear Body	Cornified Envelope Extracellular Region Basement Membrane Extracellular Space Nucleus Cytoplasm Lysosomal Membrane Endosome Early Endosome Lipid Droplet Cytosol Plasma Membrane Adherens Junction Cell Surface Vesicle Membrane Membrane Basolateral Plasma Membrane Nuclear Matrix Midbody Extracellular Matrix Late Endosome Membrane Vesicle Azurophil Granule Lumen Myelin Sheath Adaxonal Region Sarcolemma Melanosome Schmidt-Lanterman Incisure Membrane Raft Extracellular Exosome RNA Polymerase II Transcription Regulator Complex Plasma Membrane Protein Complex AnxA2-p11 Complex PCSK9-AnxA2 Complex
	Molecular Function	Phosphatidylcholine Lysophospholipase Activity Protein Binding Carbohydrate Binding	Phosphatidylserine Binding Protease Binding RNA Binding Phospholipase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Protein Binding Phospholipase A2 Inhibitor Activity Identical Protein Binding S100 Protein Binding Calcium-dependent Protein Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Phospholipid Metabolic Process Apoptotic Process	Angiogenesis Membrane Raft Assembly Positive Regulation Of Receptor Recycling Negative Regulation Of Receptor Internalization Vesicle Budding From Membrane Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Plasminogen Activation Response To Activity Collagen Fibril Organization Lung Development Positive Regulation Of Vesicle Fusion Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Osteoclast Development Fibrinolysis MRNA Transcription By RNA Polymerase II Positive Regulation Of Vacuole Organization Positive Regulation Of Exocytosis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Negative Regulation Of Transport Positive Regulation Of Multicellular Organismal Process Cell-cell Adhesion Epithelial Cell Apoptotic Process Positive Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport Positive Regulation Of Plasma Membrane Repair
Pathways			Smooth Muscle Contraction Neutrophil degranulation Dissolution of Fibrin Clot Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Developmental Lineage of Pancreatic Ductal Cells
Drugs			Tenecteplase Fluocinolone acetonide Lanoteplase Artenimol
Diseases
GWAS		Lead levels ( 26025379)	Asthma ( 31959851) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Blood protein levels ( 30072576) Night sleep phenotypes ( 27126917) Type 2 diabetes ( 25102180)
Interacting Genes		10 interacting genes: ACTB ACTG1 ANXA2 CREB5 HOXA1 NUFIP2 OTX1 PACSIN3 PHLDA1 POU4F2	51 interacting genes: ACTA1 APOH APP CCDC32 CD99 CDC42 CEACAM1 CTSB CTSS DYSF EIF4ENIF1 FNDC3B FOXP1 GRB2 HMGA1 LGALS13 LINC00941 LINC01554 LYPLA1 MAP3K4 MYOC NOD2 OGDH PHB1 PLA1A PLA2G4A PLAT PLG POT1 PRKCA PRKCB PTEN RPS2 S100A10 S100A4 S100A6 SLC26A4-AS1 SMN1 SNCA SNX17 SOS1 SRC STAT6 TENT2 TERF1 TERT TNC TRPV5 WEE2-AS1 YWHAQ ZBTB4
Entrez ID		29124	302
HPRD ID		16375	01061
Ensembl ID		ENSG00000105198	ENSG00000182718
Uniprot IDs		Q9UHV8	A0A024R5Z7 H0YL33 P07355
PDB IDs		5XG7 5XG8 5Y03 6A62 6A63 6A64 6A65 6A66 6KJW 6KJX 6KJY	1W7B 1XJL 2HYU 2HYV 2HYW 4DRW 4FTG 4HRH 5LPU 5LPX 5LQ0 5LQ2 5N7D 5N7F 5N7G 6TWQ 6TWU 6TWX 6TWY 7DTO 7EQ7 7NMI 7P70 7P71 7P72 7P73 7P74 7PC3 7PC4 7PC5 7PC7 7PC8 7PC9 7PCB 7QQL 7QQM 7QQN 7ZVN 7ZVX 8AEL
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Metabolic Process Structural Constituent Of Postsynaptic Actin Cytoskeleton Regulation Of Transepithelial Transport Dense Body Morphogenesis Of A Polarized Epithelium Positive Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Identical Protein Binding Regulation Of Endocytosis DNA-binding Transcription Factor Activity Positive Regulation Of Biosynthetic Process Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Localization To Cell-cell Junction Calyx Of Held Postsynaptic Cytoskeleton Organization Axonogenesis Regulation Of Synaptic Vesicle Endocytosis DNA-binding Transcription Activator Activity, RNA Polymerase II-specific NuA4 Histone Acetyltransferase Complex Apical Junction Complex Regulation Of Synaptic Vesicle Recycling Maintenance Of Blood-brain Barrier Regulation Of Transcription By RNA Polymerase II Regulation Of Vesicle-mediated Transport DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleus Sequence-specific Double-stranded DNA Binding Platelet Aggregation Cell Projection Morphogenesis Neuron Projection Morphogenesis Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Basal Body Patch Positive Regulation Of Transcription By RNA Polymerase II Semicircular Canal Formation Diencephalon Morphogenesis Homotypic Cell-cell Adhesion Negative Regulation Of Endocytosis Cytoskeletal Protein Binding Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Protein Localization To Cell Junction Regulation Of RNA Biosynthetic Process Regulation Of Norepinephrine Uptake Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport	Regulation Of Vesicle-mediated Transport Extracellular Exosome Regulation Of Cell Population Proliferation Enzyme Binding Regulation Of Locomotion Negative Regulation Of Wound Healing Regulation Of Transport Nuclear Telomere Cap Complex Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Migration Positive Regulation Of Metabolic Process Negative Regulation Of Fibrinolysis Leukocyte Activation Regulation Of Cell Motility Positive Regulation Of Immune System Process Histone H3T6 Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Regulation Of Cell Junction Assembly Regulation Of Fibrinolysis Negative Regulation Of Coagulation Regulation Of Cell Activation Positive Regulation Of Organelle Organization Regulation Of Immune Response Cell Activation Regulation Of Cell Adhesion Regulation Of MAPK Cascade Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Immune Response Phosphatidylcholine Lysophospholipase Activity Extracellular Matrix Identical Protein Binding Macrophage Activation Positive Regulation Of Cell Migration Regulation Of Endocytosis Negative Regulation Of Cell-substrate Adhesion Telomere Maintenance Via Telomerase Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Biosynthetic Process Regulation Of Immune System Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Myeloid Leukocyte Activation Positive Regulation Of Signal Transduction Regulation Of Cell-substrate Adhesion Regulation Of Focal Adhesion Assembly Trans-synaptic Signaling By BDNF Protein Kinase C Signaling
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