CHRDL2 and BMP7

Number of citations of the paper that reports this interaction (PubMedID 14660436)
0

Data Source:
HPRD (in vivo)

		CHRDL2	BMP7
Description		chordin like 2	bone morphogenetic protein 7
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Extracellular Region Extracellular Space Vesicle
	Molecular Function	Protein Binding BMP Binding	Cytokine Activity Protein Binding Growth Factor Activity Heparin Binding Protein Serine/threonine Kinase Activator Activity Receptor Ligand Activity BMP Receptor Binding
	Biological Process	Ossification Cell Differentiation Negative Regulation Of BMP Signaling Pathway System Development Cartilage Development	Skeletal System Development Ossification Osteoblast Differentiation Eye Development Metanephros Development Ureteric Bud Development Mesoderm Formation Kidney Development Mesonephros Development Epithelial To Mesenchymal Transition Endocardial Cushion Formation Pericardium Morphogenesis Pattern Specification Process Axon Guidance Salivary Gland Morphogenesis Heart Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Embryonic Pattern Specification Animal Organ Morphogenesis Positive Regulation Of Gene Expression Negative Regulation Of Striated Muscle Cell Apoptotic Process Positive Regulation Of Epithelial To Mesenchymal Transition Dendrite Development Neural Fold Elevation Formation Cell Differentiation Embryonic Limb Morphogenesis Positive Regulation Of Bone Mineralization BMP Signaling Pathway Epithelial Cell Differentiation Positive Regulation Of Epithelial Cell Differentiation Hindbrain Development Response To Estradiol Response To Vitamin D Positive Regulation Of Heterotypic Cell-cell Adhesion Tube Morphogenesis Ameloblast Differentiation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Apoptotic Process Response To Peptide Hormone Positive Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Development Camera-type Eye Morphogenesis Embryonic Camera-type Eye Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Cardiac Muscle Tissue Development Branching Morphogenesis Of An Epithelial Tube Mesenchymal Cell Differentiation Neuron Projection Morphogenesis Negative Regulation Of Neurogenesis Cartilage Development Positive Regulation Of Multicellular Organismal Process Pharyngeal System Development Embryonic Skeletal Joint Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Cardiac Septum Morphogenesis Branching Involved In Salivary Gland Morphogenesis Mesenchyme Development Negative Regulation Of Prostatic Bud Formation Regulation Of Branching Involved In Prostate Gland Morphogenesis Chorio-allantoic Fusion Heart Trabecula Morphogenesis Monocyte Aggregation Cellular Response To Hypoxia Cellular Response To BMP Stimulus Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis Negative Regulation Of Glomerular Mesangial Cell Proliferation Metanephric Mesenchyme Morphogenesis Nephrogenic Mesenchyme Morphogenesis Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Positive Regulation Of Brown Fat Cell Differentiation Cell-cell Adhesion Positive Regulation Of Dendrite Development Positive Regulation Of Hyaluranon Cable Assembly Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Allantois Development Positive Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Multicellular Organismal Development Regulation Of Removal Of Superoxide Radicals
Pathways			Molecules associated with elastic fibres Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
Drugs
Diseases
GWAS		Allergic rhinitis ( 25085501) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Microalbuminuria ( 26631737) Spine bone size ( 31053729)	Apolipoprotein A1 levels ( 32203549) Cerebrospinal P-tau181p levels ( 28247064) Cognitive decline rate in late mild cognitive impairment ( 26252872) Cortisol levels (saliva) ( 28843169) Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Distal colorectal cancer ( 33632709) Distal/Left-sided colorectal cancer ( 33632709) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Metopic nonsyndromic craniosynostosis ( 32266521) Microalbuminuria in type 1 diabetes ( 31537649) Monobrow ( 27182965) Nose size ( 27182965) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 27021288) Response to citalopram treatment ( 19846067) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) White blood cell types ( 21738478)
Interacting Genes		21 interacting genes: BANP BMP2 BMP4 BMP5 BMP6 BMP7 CHRD ENKD1 FAH FAM90A1 GDF5 GPSM3 HOXA1 INHBA MAPRE3 OTX1 PIK3R3 POU4F2 SLIT1 ZNF417 ZNF587	32 interacting genes: ACTN4 ACVR1 ACVR2A ACVR2B BEGAIN BMPR1A BMPR1B BMPR2 CCDC125 CHRDL2 CRIPTO CYSRT1 ENG GDF7 KHDRBS2 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP3-1 KRTAP5-9 KRTAP9-8 MTUS2 NBPF19 NCOA3 NOG NOTCH2NLA SOSTDC1 TRIM27
Entrez ID		25884	655
HPRD ID		09881	00212
Ensembl ID		ENSG00000054938	ENSG00000101144
Uniprot IDs		Q6WN34	A8K571 P18075
PDB IDs			1BMP 1LX5 1LXI 1M4U
Enriched GO Terms of Interacting Partners?		Positive Regulation Of SMAD Protein Signal Transduction Regulation Of SMAD Protein Signal Transduction BMP Receptor Binding BMP Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Growth Factor Activity Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Activator Complex Cartilage Development Cytokine Activity Ossification Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Cell Differentiation Ameloblast Differentiation Cellular Response To BMP Stimulus Positive Regulation Of Cartilage Development Positive Regulation Of Neuron Differentiation Skeletal System Development Regulation Of Aldosterone Biosynthetic Process Regulation Of Neuron Differentiation Positive Regulation Of Bone Mineralization Endocardial Cushion Formation Type B Pancreatic Cell Development Positive Regulation Of Biomineral Tissue Development Regulation Of Cell Differentiation Positive Regulation Of Ossification Heart Development Negative Regulation Of Developmental Process Regulation Of Osteoblast Differentiation Regulation Of Steroid Hormone Biosynthetic Process Positive Regulation Of Epithelial Cell Differentiation Protein Serine/threonine Kinase Activator Activity Regulation Of Cartilage Development Positive Regulation Of Osteoblast Differentiation Regulation Of Locomotion Regulation Of Ketone Biosynthetic Process Regulation Of Bone Mineralization Regulation Of Hormone Biosynthetic Process Anatomical Structure Morphogenesis Negative Regulation Of Glomerular Mesangial Cell Proliferation Positive Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Neural Fold Elevation Formation Positive Regulation Of Cell Differentiation Regulation Of Animal Organ Formation Odontogenesis Pattern Specification Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Aldosterone Biosynthetic Process	BMP Signaling Pathway BMP Receptor Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Signaling Pathway Keratin Filament Intermediate Filament BMP Binding Cellular Response To BMP Stimulus Regulation Of SMAD Protein Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Binding Positive Regulation Of Osteoblast Differentiation Activin Receptor Activity, Type II Regulation Of Bone Mineralization Regulation Of Osteoblast Differentiation Enzyme-linked Receptor Protein Signaling Pathway Growth Factor Binding Regionalization Pattern Specification Process Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Activity, Type I Mesoderm Development Regulation Of Ossification Response To Growth Factor Osteoblast Differentiation Outflow Tract Septum Morphogenesis Activin Receptor Complex Cardiac Septum Morphogenesis Mitral Valve Morphogenesis Tissue Development Anterior/posterior Pattern Specification Ventricular Septum Morphogenesis Pharyngeal Arch Artery Morphogenesis Endocardial Cushion Formation Receptor Complex Mesoderm Formation Morphogenesis Of An Epithelial Fold Gastrulation With Mouth Forming Second Animal Organ Morphogenesis Formation Of Primary Germ Layer Artery Morphogenesis Atrioventricular Valve Morphogenesis Dorsal/ventral Pattern Formation
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