OAZ1 and PIAS4

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		OAZ1	PIAS4
Gene Name		ornithine decarboxylase antizyme 1	protein inhibitor of activated STAT, 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Nucleus Nucleoplasm Cytoplasm Nuclear Matrix PML Body
	Molecular Function	Protein Binding Ornithine Decarboxylase Inhibitor Activity	DNA Binding Protein Binding Zinc Ion Binding Ligase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding SUMO Ligase Activity
	Biological Process	Regulation Of Cellular Amino Acid Metabolic Process Polyamine Biosynthetic Process Transport Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Catalytic Activity Small Molecule Metabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Intracellular Protein Transport Negative Regulation Of Polyamine Transmembrane Transport	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Wnt Signaling Pathway Protein Sumoylation Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Sumoylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Keratinocyte Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways		Regulation of ornithine decarboxylase (ODC) Metabolism of amino acids and derivatives
Drugs		L-Ornithine
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ATXN1 EGFR OAZ2 OAZ3 ODC1 PIAS4 PSMB4 SMAD1	75 interactors: ACTN1 ALDOA AR BARD1 BRCA1 BTAF1 CALCOCO2 CEBPD CHD3 CLK1 COIL ESRRA FTH1 GADD45G HDAC1 HDAC2 HNF4A HNRNPUL1 HTT IL15RA IMMT IMPDH2 IRF3 IRF7 KPNB1 KRT18 LAMP2 LEF1 LRIF1 MAGEH1 MAP1LC3A MDC1 MPRIP NEFL NR4A2 OAZ1 OPTN PARP1 PDE4A PDE4D PDE4DIP PHF11 PHGDH PIAS1 PIAS2 PLAG1 PRPF40A PTN RIF1 SATB1 SERBP1 SERPINA5 SETDB1 SH3GL3 SKIL SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 SNIP1 SUMO1 SUMO2 SUMO3 TADA3 TCERG1 TICAM1 TP53 TRIM27 TRIM32 UBE2I UBE2K VIM ZHX1 ZNF512B
Entrez ID		4946	51588
HPRD ID		03346	06910
Ensembl ID		ENSG00000104904
Uniprot IDs		P54368	Q8N2W9
PDB IDs
Enriched GO Terms of Interacting Partners?		Polyamine Biosynthetic Process Amine Biosynthetic Process Regulation Of Protein Catabolic Process Regulation Of Cellular Amino Acid Metabolic Process Polyamine Metabolic Process Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Polyamine Transmembrane Transport Regulation Of Nitrogen Compound Metabolic Process Cellular Biogenic Amine Metabolic Process Positive Regulation Of Metabolic Process Amine Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Biosynthetic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transmembrane Transport Positive Regulation Of Response To DNA Damage Stimulus Nitrogen Compound Metabolic Process Alkanesulfonate Metabolic Process Putrescine Biosynthetic Process From Ornithine Positive Regulation Of Cellular Metabolic Process Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Positive Regulation Of Keratinocyte Apoptotic Process Putrescine Transport Astrocyte Activation Regulation Of Response To DNA Damage Stimulus Regulation Of Apoptotic Process Putrescine Biosynthetic Process Regulation Of Cell Death Cellular Metabolic Process G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Intracellular Protein Transport Tube Development Activation Of Phospholipase A2 Activity Positive Regulation Of Phospholipase A2 Activity Negative Regulation Of Catalytic Activity Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Reproductive Process Response To Cobalamin Response To UV-A Primary MiRNA Processing Multicellular Organism Reproduction Response To Hydroxyisoflavone Negative Regulation Of Mitotic Cell Cycle MAPK Cascade Gene Expression Ornithine Metabolic Process Osteoblast Fate Commitment	Negative Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Cellular Response To Organic Substance Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of Transcription, DNA-templated Response To Organic Substance Regulation Of Cellular Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Gene Expression Response To Stimulus Positive Regulation Of Gene Expression Protein Sumoylation DNA-templated Transcription, Initiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Cellular Response To Organic Cyclic Compound Positive Regulation Of Transcription, DNA-templated Transforming Growth Factor Beta Receptor Signaling Pathway Response To Stress Macromolecule Biosynthetic Process Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Cellular Metabolic Process Response To Transforming Growth Factor Beta Regulation Of Cell Death
Tagcloud ?		anticipate cbx3 cyp2a6 disc downloaded fntb gse1648 hyper hypo inferred intervertebral iso ivd normalization npm1 omnibus osmotic pair physicochemical physiologic prpf8 rps5 slc25a3 srsf9 stimuli tardbp thoughts top tsp	acceptor acetyltransferase alignment consensus consequently deacetylase dgcr8 e195a e3 ing ing1 ing1b ing2 ing3 ings isg15 k193 ligase marks mislocalized pdsm phosphomimic preferred reveals s199d stoichiometric sumo sumoylation suppressors
Tagcloud (Difference) ?		anticipate cbx3 cyp2a6 disc downloaded fntb gse1648 hyper hypo inferred intervertebral iso ivd normalization npm1 omnibus osmotic pair physicochemical physiologic prpf8 rps5 slc25a3 srsf9 stimuli tardbp thoughts top tsp	acceptor acetyltransferase alignment consensus consequently deacetylase dgcr8 e195a e3 ing ing1 ing1b ing2 ing3 ings isg15 k193 ligase marks mislocalized pdsm phosphomimic preferred reveals s199d stoichiometric sumo sumoylation suppressors
Tagcloud (Intersection) ?