NRAP and TLN1

Number of citations of the paper that reports this interaction (PubMedID 10320340)
0

Data Source:
HPRD (in vitro)

		NRAP	TLN1
Description		nebulin related anchoring protein	talin 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Fascia Adherens Muscle Tendon Junction Myofibril Z Disc	Ruffle Extracellular Region Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Cell Surface Membrane Ruffle Membrane Cell Projection Extracellular Exosome Anchoring Junction
	Molecular Function	Actin Binding Protein Binding Vinculin Binding Metal Ion Binding Actin Filament Binding Muscle Alpha-actinin Binding	Phosphatidylserine Binding Actin Binding Integrin Binding Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding LIM Domain Binding Phosphatidylinositol Binding Cadherin Binding Actin Filament Binding
	Biological Process	Cardiac Muscle Thin Filament Assembly	Cell-cell Junction Assembly Cell-substrate Junction Assembly Cell Adhesion Integrin-mediated Signaling Pathway Actin Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Integrin Activation Cortical Microtubule Organization Regulation Of Focal Adhesion Assembly Platelet Aggregation Cell-cell Adhesion
Pathways			Platelet degranulation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins XBP1(S) activates chaperone genes SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Smooth Muscle Contraction MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Plasma factor VII activating protease levels ( 30070759) QT interval ( 29874175)	Brain morphology (MOSTest) ( 32665545) IgE levels in asthmatics ( 23967269) Lymphocyte count ( 32888494) Monocyte count ( 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494)
Interacting Genes		8 interacting genes: ACTA1 ACTB ACTN3 KLHL41 PRKAA2 TLN1 TRIM63 VCL	37 interacting genes: ABI1 ACTA1 ARHGAP31 AZIN2 CDK5 CEBPA DAG1 DOK1 EGFR ERBB2 FMO1 HSP90AA1 ITGA1 ITGA2B ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 LRP2 MTNR1A MTNR1B NRAP NYAP1 PIP5K1C PKD1 PTK2 PTK2B PXN RET SMURF1 SUMO2 TES TPTE TUBA1A VCL YWHAQ
Entrez ID		4892	7094
HPRD ID		04189	01726
Ensembl ID		ENSG00000197893	ENSG00000137076
Uniprot IDs		A0A0A0MRM2 Q86VF7	Q9Y490
PDB IDs			1SYQ 2MWN 4DJ9 6R9T
Enriched GO Terms of Interacting Partners?		Muscle System Process Actin Cytoskeleton Brush Border Cell Junction Assembly Platelet Aggregation Homotypic Cell-cell Adhesion Regulation Of Carbohydrate Catabolic Process Regulation Of ATP Metabolic Process Regulation Of Glycolytic Process Skeletal Muscle Atrophy Skeletal Muscle Adaptation Striated Muscle Atrophy Actin Filament Muscle Atrophy Regulation Of Purine Nucleotide Metabolic Process Structural Constituent Of Cytoskeleton Actin Cytoskeleton Organization Actin Filament-based Process Cell-cell Junction Assembly Adherens Junction Assembly Focal Adhesion Regulation Of Generation Of Precursor Metabolites And Energy Pseudopodium Cell Junction Organization Negative Regulation Of Glycolytic Process Negative Regulation Of ATP Metabolic Process M Band Cell-cell Junction Organization Adherens Junction Muscle Contraction Maintenance Of Blood-brain Barrier Cell-substrate Junction Assembly Cell-substrate Junction Organization Cytoskeleton Adherens Junction Organization Sarcomere Regulation Of Small Molecule Metabolic Process Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Regulation Of Focal Adhesion Assembly Inner Dense Plaque Of Desmosome Podosome Ring Outer Dense Plaque Of Desmosome Regulation Of Myoblast Differentiation Actin Binding Regulation Of Cell-substrate Junction Organization Cytoskeleton Organization Cytoplasm Muscle Cell Development	Focal Adhesion Cell-matrix Adhesion Cell-substrate Adhesion Integrin Complex Integrin-mediated Signaling Pathway Cell Migration Receptor Complex Cell Motility Cell Adhesion Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Signal Transduction Cell Adhesion Mediated By Integrin Lamellipodium Enzyme-linked Receptor Protein Signaling Pathway Filopodium Virus Receptor Activity Regulation Of Protein Metabolic Process Cell Surface Anchoring Junction Cell Projection Symbiont Entry Into Host Cell Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Plasma Membrane Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Extracellular Exosome Signal Complex Assembly Developmental Process Integrin Binding Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Protein Metabolic Process Heterotypic Cell-cell Adhesion Biological Process Involved In Interaction With Host Neuron Projection Morphogenesis Protein Phosphatase Binding Vinculin Binding Cell Projection Morphogenesis Cell Projection Organization Ruffle Membrane Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Wound Healing, Spreading Of Epidermal Cells Integrin Alpha1-beta1 Complex Regulation Of Cell Migration Positive Regulation Of Fibroblast Migration Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Adhesion Anatomical Structure Morphogenesis Regulation Of Cell-matrix Adhesion Regulation Of Cell Development
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