NRAP and KLHL41

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)
HPRD (in vitro, two hybrid)

		NRAP	KLHL41
Description		nebulin related anchoring protein	kelch like family member 41
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Fascia Adherens Muscle Tendon Junction Myofibril Z Disc	Ruffle Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Membrane Sarcoplasmic Reticulum Pseudopodium M Band Cul3-RING Ubiquitin Ligase Complex Sarcoplasmic Reticulum Membrane Cell Projection
	Molecular Function	Actin Binding Protein Binding Vinculin Binding Metal Ion Binding Actin Filament Binding Muscle Alpha-actinin Binding	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Cardiac Muscle Thin Filament Assembly	Striated Muscle Contraction Protein Ubiquitination Myofibril Assembly Skeletal Muscle Cell Differentiation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Myoblast Differentiation Regulation Of Myoblast Proliferation Regulation Of Skeletal Muscle Cell Differentiation
Pathways			Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Plasma factor VII activating protease levels ( 30070759) QT interval ( 29874175)
Interacting Genes		8 interacting genes: ACTA1 ACTB ACTN3 KLHL41 PRKAA2 TLN1 TRIM63 VCL	9 interacting genes: IFRD1 MYBPC1 NRAP POMP RBM4 RCHY1 SLC2A4 SPMIP2 TCAP
Entrez ID		4892	10324
HPRD ID		04189	07610
Ensembl ID		ENSG00000197893	ENSG00000239474
Uniprot IDs		A0A0A0MRM2 Q86VF7	O60662
PDB IDs
Enriched GO Terms of Interacting Partners?		Muscle System Process Actin Cytoskeleton Brush Border Cell Junction Assembly Platelet Aggregation Homotypic Cell-cell Adhesion Regulation Of Carbohydrate Catabolic Process Regulation Of ATP Metabolic Process Regulation Of Glycolytic Process Skeletal Muscle Atrophy Skeletal Muscle Adaptation Striated Muscle Atrophy Actin Filament Muscle Atrophy Regulation Of Purine Nucleotide Metabolic Process Structural Constituent Of Cytoskeleton Actin Cytoskeleton Organization Actin Filament-based Process Cell-cell Junction Assembly Adherens Junction Assembly Focal Adhesion Regulation Of Generation Of Precursor Metabolites And Energy Pseudopodium Cell Junction Organization Negative Regulation Of Glycolytic Process Negative Regulation Of ATP Metabolic Process M Band Cell-cell Junction Organization Adherens Junction Muscle Contraction Maintenance Of Blood-brain Barrier Cell-substrate Junction Assembly Cell-substrate Junction Organization Cytoskeleton Adherens Junction Organization Sarcomere Regulation Of Small Molecule Metabolic Process Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Regulation Of Focal Adhesion Assembly Inner Dense Plaque Of Desmosome Podosome Ring Outer Dense Plaque Of Desmosome Regulation Of Myoblast Differentiation Actin Binding Regulation Of Cell-substrate Junction Organization Cytoskeleton Organization Cytoplasm Muscle Cell Development	Titin Binding
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