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ATP2A1 and IRS2
Number of citations of the paper that reports this interaction (PMID
9295312
)
7
Data Source:
HPRD
(in vivo, in vitro)
ATP2A1
IRS2
Gene Name
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
insulin receptor substrate 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Endoplasmic Reticulum Membrane
Endoplasmic Reticulum-Golgi Intermediate Compartment
Membrane
Integral Component Of Membrane
Sarcoplasmic Reticulum
Platelet Dense Tubular Network Membrane
H Zone
I Band
Sarcoplasmic Reticulum Membrane
Calcium Channel Complex
Perinuclear Region Of Cytoplasm
Cytosol
Plasma Membrane
Molecular Function
Calcium-transporting ATPase Activity
Calcium Ion Binding
Protein Binding
ATP Binding
Protein Homodimerization Activity
Signal Transducer Activity
Insulin Receptor Binding
Protein Binding
Protein Kinase Binding
Protein Phosphatase Binding
Protein Domain Specific Binding
Phosphatidylinositol 3-kinase Binding
14-3-3 Protein Binding
Biological Process
Calcium Ion Transport
Regulation Of Striated Muscle Contraction
Blood Coagulation
Metabolic Process
Apoptotic Mitochondrial Changes
Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction
Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration
Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration
Ion Transmembrane Transport
Response To Endoplasmic Reticulum Stress
Negative Regulation Of Striated Muscle Contraction
Positive Regulation Of Mitochondrial Calcium Ion Concentration
Maintenance Of Mitochondrion Location
Transmembrane Transport
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Calcium Ion Import
Calcium Ion Transmembrane Transport
Relaxation Of Skeletal Muscle
Positive Regulation Of Mesenchymal Cell Proliferation
Negative Regulation Of B Cell Apoptotic Process
Glucose Metabolic Process
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Brain Development
Cell Proliferation
Positive Regulation Of Cell Proliferation
Insulin Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Response To Glucose
Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport
Positive Regulation Of Glucose Metabolic Process
Regulation Of Lipid Metabolic Process
Positive Regulation Of Cell Migration
Mammary Gland Development
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Fatty Acid Beta-oxidation
Positive Regulation Of Insulin Secretion
Cellular Response To Insulin Stimulus
Negative Regulation Of Kinase Activity
Fc-epsilon Receptor Signaling Pathway
Innate Immune Response
Positive Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of Glucose Import
Neurotrophin TRK Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Lipid Homeostasis
JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Cellular Response To Glucose Stimulus
Pathways
Ion transport by P-type ATPases
Ion channel transport
Pre-NOTCH Processing in Golgi
Platelet homeostasis
Reduction of cytosolic Ca++ levels
Signaling by NOTCH
Pre-NOTCH Expression and Processing
Platelet calcium homeostasis
Signaling by the B Cell Receptor (BCR)
Signaling by FGFR in disease
Signaling by EGFRvIII in Cancer
Signaling by SCF-KIT
DAP12 signaling
Downstream signaling events of B Cell Receptor (BCR)
PI3K/AKT activation
PI-3K cascade
SOS-mediated signalling
PI3K Cascade
Signaling by PDGF
DAP12 interactions
GAB1 signalosome
Signaling by ERBB4
Role of LAT2/NTAL/LAB on calcium mobilization
Constitutive PI3K/AKT Signaling in Cancer
PI3K events in ERBB4 signaling
Signaling by ERBB2
Signaling by EGFR
Downstream signal transduction
Fc epsilon receptor (FCERI) signaling
Signaling by EGFR in Cancer
PI3K/AKT Signaling in Cancer
Signaling by Leptin
Growth hormone receptor signaling
Adaptive Immune System
IRS-mediated signalling
PIP3 activates AKT signaling
IGF1R signaling cascade
IRS-related events triggered by IGF1R
IRS activation
PI3K events in ERBB2 signaling
Downstream signaling of activated FGFR
Signaling by Insulin receptor
Innate Immune System
Signalling by NGF
Insulin receptor signalling cascade
SOS-mediated signalling
Cytokine Signaling in Immune system
IRS-related events
Signaling by Ligand-Responsive EGFR Variants in Cancer
NGF signalling via TRKA from the plasma membrane
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by FGFR
IRS-mediated signalling
Signal attenuation
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
PI3K Cascade
Drugs
Diseases
GWAS
Body mass index (
19079260
)
Weight (
19079260
)
Protein-Protein Interactions
4 interactors:
IRS1
IRS2
PLN
SLN
38 interactors:
ATP2A1
ATP2A2
BCL2L1
CRK
EPOR
FES
GRB2
IGF1R
IL4R
INSR
JAK1
JAK2
JAK3
MPL
NTRK1
PIK3CA
PIK3CD
PIK3R1
PIK3R2
PIK3R3
PLCG1
PTPN11
PTPN6
PTPRF
RPTOR
SHC1
SIRT1
SOCS1
SOCS3
SOCS6
SOCS7
TYK2
UBTF
YWHAB
YWHAE
YWHAG
YWHAQ
YWHAZ
Entrez ID
487
8660
HPRD ID
00157
02878
Ensembl ID
ENSG00000196296
ENSG00000185950
Uniprot IDs
B3KY17
O14983
Q7Z675
Q9P084
Q9Y4H2
PDB IDs
3FQW
3FQX
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Calcium Ion Binding
Negative Regulation Of Ion Transmembrane Transport
Negative Regulation Of Transmembrane Transport
Regulation Of Calcium-transporting ATPase Activity
Negative Regulation Of Transport
Negative Regulation Of Calcium Ion Import
Negative Regulation Of Ion Transport
Regulation Of Relaxation Of Muscle
Positive Regulation Of Fatty Acid Beta-oxidation
Positive Regulation Of Glycogen Biosynthetic Process
Negative Regulation Of Calcium Ion Transmembrane Transporter Activity
Positive Regulation Of Fatty Acid Oxidation
Regulation Of Fatty Acid Beta-oxidation
JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Regulation Of Calcium Ion Import
Growth Hormone Receptor Signaling Pathway
Cellular Response To Growth Hormone Stimulus
Positive Regulation Of Lipid Catabolic Process
Response To Insulin
Positive Regulation Of Fatty Acid Metabolic Process
Regulation Of Glycogen Biosynthetic Process
Regulation Of Fatty Acid Oxidation
Positive Regulation Of Glucose Metabolic Process
Regulation Of Glycogen Metabolic Process
Response To Growth Hormone
Negative Regulation Of Transporter Activity
Regulation Of ATPase Activity
Negative Regulation Of Calcium Ion Transport
Positive Regulation Of Mesenchymal Cell Proliferation
Positive Regulation Of Glucose Import
Regulation Of Ion Transmembrane Transport
Regulation Of Mesenchymal Cell Proliferation
Positive Regulation Of Glucose Transport
Response To Peptide Hormone
JAK-STAT Cascade
Regulation Of Lipid Catabolic Process
Response To Peptide
Regulation Of Calcium Ion Transmembrane Transport
Regulation Of Calcium Ion Transmembrane Transporter Activity
Regulation Of Glucose Import
Positive Regulation Of Stem Cell Proliferation
Regulation Of Generation Of Precursor Metabolites And Energy
Regulation Of Ion Transport
Regulation Of Fatty Acid Metabolic Process
Regulation Of Cellular Component Movement
Regulation Of Glucose Transport
Negative Regulation Of Binding
Regulation Of Catalytic Activity
Regulation Of Glucose Metabolic Process
Regulation Of Stem Cell Proliferation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Intracellular Signal Transduction
Cellular Response To Organonitrogen Compound
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Organic Substance
Cellular Response To Peptide
Response To Peptide Hormone
Response To Peptide
Response To Organonitrogen Compound
Response To Organic Substance
Signal Transduction
Cellular Response To Hormone Stimulus
Signaling
Cell Communication
Insulin Receptor Signaling Pathway
Regulation Of Kinase Activity
Response To Hormone
Cellular Response To Insulin Stimulus
Cell Surface Receptor Signaling Pathway
Response To Insulin
Cellular Response To Stimulus
Regulation Of Immune Response
Regulation Of Phosphorus Metabolic Process
Immune Response
Regulation Of Phosphorylation
Innate Immune Response
Defense Response
Regulation Of Protein Kinase Activity
Response To Stress
Regulation Of Signal Transduction
Regulation Of Immune System Process
Response To Stimulus
Regulation Of Signaling
Positive Regulation Of Signal Transduction
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Blood Coagulation
Hemostasis
Cytokine-mediated Signaling Pathway
Response To Cytokine
Immune System Process
Cellular Response To Cytokine Stimulus
Regulation Of Protein Phosphorylation
Cell Migration
Epidermal Growth Factor Receptor Signaling Pathway
Response To Wounding
Regulation Of Intracellular Transport
ERBB Signaling Pathway
Locomotion
Tagcloud
?
aacr
adaptive
adaptor
compensatory
conversely
cotargeting
dampen
dasatinib
ddr2
driven
emerged
gab1
harboring
igf1r
implicating
library
met
option
overlaying
panel
phosphoproteomics
py
rationale
res
rescued
rtk
scc
synergistic
weakly
Tagcloud (Difference)
?
aacr
adaptive
adaptor
compensatory
conversely
cotargeting
dampen
dasatinib
ddr2
driven
emerged
gab1
harboring
igf1r
implicating
library
met
option
overlaying
panel
phosphoproteomics
py
rationale
res
rescued
rtk
scc
synergistic
weakly
Tagcloud (Intersection)
?