ATP2A1

Name	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
Structure	No pdb structure
Interactors	8 interactors: APPL1 CCR8 IRS1 IRS2 PLN RNF167 SLN TULP3
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Sarcoplasmic Reticulum Platelet Dense Tubular Network Membrane H Zone I Band Sarcoplasmic Reticulum Membrane Calcium Channel Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding P-type Calcium Transporter Activity Calcium Ion Binding Protein Binding ATP Binding ATP Hydrolysis Activity Calcium-dependent ATPase Activity Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Regulation Of Striated Muscle Contraction Apoptotic Mitochondrial Changes Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Monoatomic Ion Transmembrane Transport Response To Endoplasmic Reticulum Stress Negative Regulation Of Striated Muscle Contraction Positive Regulation Of Mitochondrial Calcium Ion Concentration Maintenance Of Mitochondrion Location Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Calcium Ion Import Calcium Ion Transmembrane Transport Relaxation Of Skeletal Muscle Positive Regulation Of Cardiac Muscle Cell Contraction Positive Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Positive Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Regulation Of Cardiac Conduction Calcium Ion Import Into Sarcoplasmic Reticulum
Pathways	Pre-NOTCH Processing in Golgi Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases
Drugs	Enflurane Ritodrine Desflurane Sevoflurane Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate Tetrafluoroaluminate Ion 2,5-di-tert-butylhydroquinone (6AR,11AS,11BR)-10-ACETYL-9-HYDROXY-7,7-DIMETHYL-2,6,6A,7,11A,11B-HEXAHYDRO-11H-PYRROLO[1',2':2,3]ISOINDOLO[4,5,6-CD]INDOL-11-ONE
Diseases	Brody myopathy
GWAS	BMI (adjusted for smoking behaviour) ( 28443625 ) BMI in non-smokers ( 28443625 ) Body fat distribution (arm fat ratio) ( 30664634 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Body mass index ( 25673413 26961502 28892062 19079260 ) Body mass index (joint analysis main effects and smoking interaction) ( 28443625 ) Brain morphology (MOSTest) ( 32665545 ) Cannabis use ( 30150663 ) Crohn's disease ( 28067908 ) Extremely high intelligence ( 29520040 ) Hip circumference ( 31453325 25673412 ) Hip circumference variance ( 31453325 ) Inflammatory bowel disease ( 28067908 ) Intelligence ( 28530673 ) Intelligence (MTAG) ( 29326435 ) Lamb consumption ( 32066663 ) Type 2 diabetes ( 30297969 ) Waist circumference ( 31453325 ) Waist circumference variance ( 31453325 ) Weight ( 19079260 )
Entrez ID	487
HPRD ID	00157
Ensembl ID	ENSG00000196296
Uniprot IDs	O14983
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Negative Regulation Of Transport Positive Regulation Of D-glucose Import Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Positive Regulation Of D-glucose Transmembrane Transport Regulation Of D-glucose Import Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Regulation Of D-glucose Transmembrane Transport Insulin Receptor Signaling Pathway Positive Regulation Of Fatty Acid Beta-oxidation Negative Regulation Of ATP-dependent Activity Positive Regulation Of Fatty Acid Oxidation Negative Regulation Of Calcium Ion Import Negative Regulation Of Transmembrane Transport Regulation Of Fatty Acid Beta-oxidation Phosphatidylinositol 3-kinase Binding Positive Regulation Of Glycogen Biosynthetic Process Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Relaxation Of Muscle Insulin Receptor Binding Response To Insulin Cell Surface Receptor Signaling Pathway Positive Regulation Of Lipid Catabolic Process Negative Regulation Of Transporter Activity Regulation Of Glycogen Biosynthetic Process Regulation Of Fatty Acid Oxidation Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of ATP-dependent Activity Positive Regulation Of Fatty Acid Metabolic Process Sarcoplasmic Reticulum Membrane Negative Regulation Of Calcium Ion Transmembrane Transport Regulation Of Glycogen Metabolic Process Regulation Of Calcium Ion Import Positive Regulation Of Glucose Metabolic Process Negative Regulation Of Calcium Ion Transport Regulation Of Transport Response To Peptide Hormone Negative Regulation Of Intracellular Transport Regulation Of Lipid Catabolic Process Enzyme Inhibitor Activity Sarcoplasmic Reticulum Negative Regulation Of Cation Transmembrane Transport Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Monoatomic Ion Transmembrane Transport Signaling Adaptor Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity