ATP2A1 and PLN

Number of citations of the paper that reports this interaction (PMID 10551848)
21

Data Source:
HPRD (in vitro, in vivo)

		ATP2A1	PLN
Gene Name		ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	phospholamban
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Integral Component Of Membrane Sarcoplasmic Reticulum Platelet Dense Tubular Network Membrane H Zone I Band Sarcoplasmic Reticulum Membrane Calcium Channel Complex Perinuclear Region Of Cytoplasm	Mitochondrion Endoplasmic Reticulum Membrane Mitochondrial Membrane Vesicle Sarcoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm Calcium Ion-transporting ATPase Complex
	Molecular Function	Calcium-transporting ATPase Activity Calcium Ion Binding Protein Binding ATP Binding Protein Homodimerization Activity	Enzyme Inhibitor Activity Calcium Channel Regulator Activity Protein Binding ATPase Inhibitor Activity Identical Protein Binding ATPase Binding
	Biological Process	Calcium Ion Transport Regulation Of Striated Muscle Contraction Blood Coagulation Metabolic Process Apoptotic Mitochondrial Changes Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Ion Transmembrane Transport Response To Endoplasmic Reticulum Stress Negative Regulation Of Striated Muscle Contraction Positive Regulation Of Mitochondrial Calcium Ion Concentration Maintenance Of Mitochondrion Location Transmembrane Transport Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Calcium Ion Import Calcium Ion Transmembrane Transport Relaxation Of Skeletal Muscle	Regulation Of The Force Of Heart Contraction Calcium Ion Transport Blood Circulation Regulation Of Heart Contraction Response To Zinc Ion Negative Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of ATPase Activity Response To Insulin Response To Testosterone Negative Regulation Of Catalytic Activity Cardiac Muscle Tissue Development Protein Homooligomerization Cytosolic Calcium Ion Homeostasis Regulation Of Calcium Ion Transport Negative Regulation Of Calcium Ion Transport Relaxation Of Cardiac Muscle Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Cell Contraction Adrenergic Receptor Signaling Pathway Involved In Heart Process Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of The Force Of Heart Contraction By Cardiac Conduction Negative Regulation Of Calcium Ion Import Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Calcium Ion Binding Regulation Of Calcium-transporting ATPase Activity Negative Regulation Of Calcium-transporting ATPase Activity Regulation Of Relaxation Of Cardiac Muscle Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum
Pathways		Ion transport by P-type ATPases Ion channel transport Pre-NOTCH Processing in Golgi Platelet homeostasis Reduction of cytosolic Ca++ levels Signaling by NOTCH Pre-NOTCH Expression and Processing Platelet calcium homeostasis	Ion transport by P-type ATPases Ion channel transport
Drugs
Diseases
GWAS		Body mass index ( 19079260) Weight ( 19079260)	Cardiac structure and function ( 19584346) QT interval ( 23166209 19305408 19305409 19587794) Ventricular conduction ( 21076409)
Protein-Protein Interactions		4 interactors: IRS1 IRS2 PLN SLN	11 interactors: ATP2A1 ATP2A2 DMPK DVL3 EDA LDLRAD1 PPP1R3A PRKACA S100A1 SLN TMEM79
Entrez ID		487	5350
HPRD ID		00157	01395
Ensembl ID		ENSG00000196296	ENSG00000198523
Uniprot IDs		B3KY17 O14983 Q7Z675	P26678 Q5R352
PDB IDs			1K9N 1KCH 1PLN 1PLP 1PSL 1ZLL 2HYN
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Calcium Ion Binding Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Regulation Of Calcium-transporting ATPase Activity Negative Regulation Of Transport Negative Regulation Of Calcium Ion Import Negative Regulation Of Ion Transport Regulation Of Relaxation Of Muscle Positive Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of Fatty Acid Oxidation Regulation Of Fatty Acid Beta-oxidation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Calcium Ion Import Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Positive Regulation Of Lipid Catabolic Process Response To Insulin Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Fatty Acid Oxidation Positive Regulation Of Glucose Metabolic Process Regulation Of Glycogen Metabolic Process Response To Growth Hormone Negative Regulation Of Transporter Activity Regulation Of ATPase Activity Negative Regulation Of Calcium Ion Transport Positive Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Glucose Import Regulation Of Ion Transmembrane Transport Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Glucose Transport Response To Peptide Hormone JAK-STAT Cascade Regulation Of Lipid Catabolic Process Response To Peptide Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Glucose Import Positive Regulation Of Stem Cell Proliferation Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Ion Transport Regulation Of Fatty Acid Metabolic Process Regulation Of Cellular Component Movement Regulation Of Glucose Transport Negative Regulation Of Binding Regulation Of Catalytic Activity Regulation Of Glucose Metabolic Process Regulation Of Stem Cell Proliferation	Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Regulation Of Heart Contraction Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Regulation Of Striated Muscle Contraction Sarcoplasmic Reticulum Calcium Ion Transport Chemical Homeostasis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Metal Ion Homeostasis Regulation Of Muscle Contraction Relaxation Of Muscle Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Cellular Chemical Homeostasis Ion Homeostasis Regulation Of Calcium Ion Transport Regulation Of Body Fluid Levels Regulation Of The Force Of Heart Contraction Calcium Ion Import Endoplasmic Reticulum Calcium Ion Homeostasis Homeostatic Process Cellular Homeostasis Epidermis Development Multicellular Organismal Water Homeostasis Calcium Ion Transport Water Homeostasis Nuclear Envelope Organization Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Positive Regulation Of Dense Core Granule Biogenesis Calcium Ion Import Into Sarcoplasmic Reticulum Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Regulation Of Cation Channel Activity Intracellular Signal Transduction Programmed Cell Death Regulation Of Ion Transmembrane Transport Blood Coagulation Hemostasis Cell Death Death Calcium-mediated Signaling Hair Follicle Development Hair Cycle Process Epithelium Development
Tagcloud ?			augment axillary ccr7 cd45 clue conditioned cues deadly drained emerge fivefold infiltrated infiltrating intriguingly leukocyte leukocytes lymph mcf microenvironment nln nlns nodes plns secreted secretions skbr3 subsets tals tributaries
Tagcloud (Difference) ?			augment axillary ccr7 cd45 clue conditioned cues deadly drained emerge fivefold infiltrated infiltrating intriguingly leukocyte leukocytes lymph mcf microenvironment nln nlns nodes plns secreted secretions skbr3 subsets tals tributaries
Tagcloud (Intersection) ?