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ATP2A1 and IRS1
Number of citations of the paper that reports this interaction (PMID
9295312
)
7
Data Source:
HPRD
(in vivo)
ATP2A1
IRS1
Gene Name
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
insulin receptor substrate 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Endoplasmic Reticulum Membrane
Endoplasmic Reticulum-Golgi Intermediate Compartment
Membrane
Integral Component Of Membrane
Sarcoplasmic Reticulum
Platelet Dense Tubular Network Membrane
H Zone
I Band
Sarcoplasmic Reticulum Membrane
Calcium Channel Complex
Perinuclear Region Of Cytoplasm
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Insulin Receptor Complex
Caveola
Ciliary Basal Body
Intracellular Membrane-bounded Organelle
Molecular Function
Calcium-transporting ATPase Activity
Calcium Ion Binding
Protein Binding
ATP Binding
Protein Homodimerization Activity
Signal Transducer Activity
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Protein Kinase C Binding
Insulin Receptor Binding
Insulin-like Growth Factor Receptor Binding
Protein Binding
SH2 Domain Binding
Phosphatidylinositol 3-kinase Binding
Biological Process
Calcium Ion Transport
Regulation Of Striated Muscle Contraction
Blood Coagulation
Metabolic Process
Apoptotic Mitochondrial Changes
Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction
Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration
Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration
Ion Transmembrane Transport
Response To Endoplasmic Reticulum Stress
Negative Regulation Of Striated Muscle Contraction
Positive Regulation Of Mitochondrial Calcium Ion Concentration
Maintenance Of Mitochondrion Location
Transmembrane Transport
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Calcium Ion Import
Calcium Ion Transmembrane Transport
Relaxation Of Skeletal Muscle
Positive Regulation Of Mesenchymal Cell Proliferation
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Cell Proliferation
Insulin Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Gene Expression
Positive Regulation Of Glucose Metabolic Process
Phosphatidylinositol 3-kinase Signaling
Lipid Catabolic Process
Positive Regulation Of Cell Migration
Mammary Gland Development
Positive Regulation Of Fatty Acid Beta-oxidation
Response To Insulin
Cellular Response To Insulin Stimulus
Protein Localization To Nucleus
Fc-epsilon Receptor Signaling Pathway
Glucose Homeostasis
Response To Peptide Hormone
Protein Kinase B Signaling
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Innate Immune Response
Positive Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of Glucose Import
Negative Regulation Of Insulin Receptor Signaling Pathway
Positive Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Insulin Secretion
Insulin-like Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Positive Regulation Of Glucose Import In Response To Insulin Stimulus
Pathways
Ion transport by P-type ATPases
Ion channel transport
Pre-NOTCH Processing in Golgi
Platelet homeostasis
Reduction of cytosolic Ca++ levels
Signaling by NOTCH
Pre-NOTCH Expression and Processing
Platelet calcium homeostasis
Signaling by the B Cell Receptor (BCR)
Signaling by FGFR in disease
Signaling by EGFRvIII in Cancer
Signaling by SCF-KIT
DAP12 signaling
Downstream signaling events of B Cell Receptor (BCR)
PI3K/AKT activation
PI-3K cascade
SOS-mediated signalling
PI3K Cascade
Signaling by PDGF
DAP12 interactions
GAB1 signalosome
Signaling by ERBB4
Role of LAT2/NTAL/LAB on calcium mobilization
Constitutive PI3K/AKT Signaling in Cancer
PI3K events in ERBB4 signaling
Signaling by ERBB2
Signaling by EGFR
Downstream signal transduction
Fc epsilon receptor (FCERI) signaling
Signaling by EGFR in Cancer
PI3K/AKT Signaling in Cancer
Signaling by Leptin
Growth hormone receptor signaling
Adaptive Immune System
IRS-mediated signalling
PIP3 activates AKT signaling
IGF1R signaling cascade
IRS-related events triggered by IGF1R
IRS activation
PI3K events in ERBB2 signaling
Downstream signaling of activated FGFR
Signaling by Insulin receptor
Innate Immune System
Signalling by NGF
Insulin receptor signalling cascade
SOS-mediated signalling
Cytokine Signaling in Immune system
IRS-related events
Signaling by Ligand-Responsive EGFR Variants in Cancer
NGF signalling via TRKA from the plasma membrane
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by FGFR
IRS-mediated signalling
Signal attenuation
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
PI3K Cascade
Drugs
[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID
Diseases
GWAS
Body mass index (
19079260
)
Weight (
19079260
)
Adiponectin levels (
22479202
)
Adiposity (
21706003
)
Fasting insulin-related traits (interaction with BMI) (
22581228
)
HDL cholesterol (
20686565
)
Triglycerides (
20686565
)
Type 2 diabetes (
20581827
)
Type 2 diabetes and other traits (
19734900
)
Visceral adipose tissue/subcutaneous adipose tissue ratio (
22589738
)
Protein-Protein Interactions
4 interactors:
IRS1
IRS2
PLN
SLN
73 interactors:
AKT1
ALK
AP3S1
APP
ATP2A1
ATP2A2
ATP2A3
BCL2L1
BCR
CAV1
CDH1
CHUK
CRK
CSNK2A1
CSNK2B
EGFR
ERBB2
FBXO25
FBXW8
FER
FES
FYN
GHR
GRB10
GRB14
GRB2
IGF1R
IKBKB
IL4R
INSR
JAK1
JAK2
JAK3
MAPK1
MAPK8
MAPK9
MTOR
NCK2
NEDD4
NPM1
NTRK1
PDPK1
PHIP
PIK3R1
PIK3R2
PIK3R3
PLCG2
PRKCD
PRKCG
PRKCQ
PRKCZ
PTK2
PTPN1
PTPN11
PTPRC
PTPRF
PTPRU
RAD51
ROCK1
RPS6KB1
RPTOR
SH2B1
SHC1
SIK2
SOCS1
SOCS3
TUB
TYK2
UBTF
YWHAB
YWHAE
YWHAG
YWHAZ
Entrez ID
487
3667
HPRD ID
00157
00943
Ensembl ID
ENSG00000196296
ENSG00000169047
Uniprot IDs
B3KY17
O14983
Q7Z675
P35568
PDB IDs
1IRS
1K3A
1QQG
2Z8C
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Calcium Ion Binding
Negative Regulation Of Ion Transmembrane Transport
Negative Regulation Of Transmembrane Transport
Regulation Of Calcium-transporting ATPase Activity
Negative Regulation Of Transport
Negative Regulation Of Calcium Ion Import
Negative Regulation Of Ion Transport
Regulation Of Relaxation Of Muscle
Positive Regulation Of Fatty Acid Beta-oxidation
Positive Regulation Of Glycogen Biosynthetic Process
Negative Regulation Of Calcium Ion Transmembrane Transporter Activity
Positive Regulation Of Fatty Acid Oxidation
Regulation Of Fatty Acid Beta-oxidation
JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Regulation Of Calcium Ion Import
Growth Hormone Receptor Signaling Pathway
Cellular Response To Growth Hormone Stimulus
Positive Regulation Of Lipid Catabolic Process
Response To Insulin
Positive Regulation Of Fatty Acid Metabolic Process
Regulation Of Glycogen Biosynthetic Process
Regulation Of Fatty Acid Oxidation
Positive Regulation Of Glucose Metabolic Process
Regulation Of Glycogen Metabolic Process
Response To Growth Hormone
Negative Regulation Of Transporter Activity
Regulation Of ATPase Activity
Negative Regulation Of Calcium Ion Transport
Positive Regulation Of Mesenchymal Cell Proliferation
Positive Regulation Of Glucose Import
Regulation Of Ion Transmembrane Transport
Regulation Of Mesenchymal Cell Proliferation
Positive Regulation Of Glucose Transport
Response To Peptide Hormone
JAK-STAT Cascade
Regulation Of Lipid Catabolic Process
Response To Peptide
Regulation Of Calcium Ion Transmembrane Transport
Regulation Of Calcium Ion Transmembrane Transporter Activity
Regulation Of Glucose Import
Positive Regulation Of Stem Cell Proliferation
Regulation Of Generation Of Precursor Metabolites And Energy
Regulation Of Ion Transport
Regulation Of Fatty Acid Metabolic Process
Regulation Of Cellular Component Movement
Regulation Of Glucose Transport
Negative Regulation Of Binding
Regulation Of Catalytic Activity
Regulation Of Glucose Metabolic Process
Regulation Of Stem Cell Proliferation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Cellular Response To Organonitrogen Compound
Cell Surface Receptor Signaling Pathway
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Peptide
Response To Organic Substance
Cellular Response To Organic Substance
Response To Organonitrogen Compound
Signal Transduction
Intracellular Signal Transduction
Signaling
Regulation Of Signal Transduction
Response To Peptide Hormone
Cell Communication
Cellular Response To Hormone Stimulus
Insulin Receptor Signaling Pathway
Response To Peptide
Cellular Response To Stimulus
Response To Hormone
Regulation Of Signaling
Regulation Of Immune Response
Positive Regulation Of Signal Transduction
Cellular Response To Insulin Stimulus
Innate Immune Response
Regulation Of Kinase Activity
Regulation Of Phosphorylation
Regulation Of Immune System Process
Immune Response
Response To Stimulus
Response To Insulin
Defense Response
Regulation Of Phosphorus Metabolic Process
Response To Stress
Immune System Process
Fc Receptor Signaling Pathway
Blood Coagulation
Hemostasis
Protein Phosphorylation
Regulation Of Protein Kinase Activity
Regulation Of Body Fluid Levels
Regulation Of Protein Metabolic Process
Phosphate-containing Compound Metabolic Process
Neurotrophin TRK Receptor Signaling Pathway
Phosphorylation
Neurotrophin Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Protein Autophosphorylation
Response To Wounding
Regulation Of Protein Phosphorylation
Tagcloud
?
action
adipocytes
biochem
biophys
coimmunoprecipitation
coincided
commun
docking
evidenced
extent
gh
initiating
insulin
involvement
kda
kinase
phosphatidylinositol
phosphorylated
pi
postreceptor
res
ridderstrale
seems
substrate
thereby
tornqvist
tyrosine
wortmannin
Tagcloud (Difference)
?
action
adipocytes
biochem
biophys
coimmunoprecipitation
coincided
commun
docking
evidenced
extent
gh
initiating
insulin
involvement
kda
kinase
phosphatidylinositol
phosphorylated
pi
postreceptor
res
ridderstrale
seems
substrate
thereby
tornqvist
tyrosine
wortmannin
Tagcloud (Intersection)
?