ATP2A1 and SLN

Number of citations of the paper that reports this interaction (PMID 9575189)
32

Data Source:
HPRD (in vivo)

		ATP2A1	SLN
Gene Name		ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	sarcolipin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Integral Component Of Membrane Sarcoplasmic Reticulum Platelet Dense Tubular Network Membrane H Zone I Band Sarcoplasmic Reticulum Membrane Calcium Channel Complex Perinuclear Region Of Cytoplasm	Integral Component Of Membrane Sarcoplasmic Reticulum Sarcoplasmic Reticulum Membrane
	Molecular Function	Calcium-transporting ATPase Activity Calcium Ion Binding Protein Binding ATP Binding Protein Homodimerization Activity	Enzyme Inhibitor Activity ATPase Binding
	Biological Process	Calcium Ion Transport Regulation Of Striated Muscle Contraction Blood Coagulation Metabolic Process Apoptotic Mitochondrial Changes Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Ion Transmembrane Transport Response To Endoplasmic Reticulum Stress Negative Regulation Of Striated Muscle Contraction Positive Regulation Of Mitochondrial Calcium Ion Concentration Maintenance Of Mitochondrion Location Transmembrane Transport Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Calcium Ion Import Calcium Ion Transmembrane Transport Relaxation Of Skeletal Muscle	Calcium Ion Transport Negative Regulation Of Catalytic Activity Negative Regulation Of Protein Complex Disassembly Regulation Of Calcium Ion Transport Sarcoplasmic Reticulum Calcium Ion Transport Negative Regulation Of Calcium Ion Import Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Relaxation Of Muscle Negative Regulation Of Calcium Ion Binding Positive Regulation Of Protein Depolymerization Regulation Of Calcium-transporting ATPase Activity
Pathways		Ion transport by P-type ATPases Ion channel transport Pre-NOTCH Processing in Golgi Platelet homeostasis Reduction of cytosolic Ca++ levels Signaling by NOTCH Pre-NOTCH Expression and Processing Platelet calcium homeostasis
Drugs
Diseases
GWAS		Body mass index ( 19079260) Weight ( 19079260)
Protein-Protein Interactions		4 interactors: IRS1 IRS2 PLN SLN	5 interactors: ATP2A1 CCDC155 PLN SYNE4 TMEM79
Entrez ID		487	6588
HPRD ID		00157	03729
Ensembl ID		ENSG00000196296	ENSG00000170290
Uniprot IDs		B3KY17 O14983 Q7Z675	O00631
PDB IDs			1JDM
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Calcium Ion Binding Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Regulation Of Calcium-transporting ATPase Activity Negative Regulation Of Transport Negative Regulation Of Calcium Ion Import Negative Regulation Of Ion Transport Regulation Of Relaxation Of Muscle Positive Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of Fatty Acid Oxidation Regulation Of Fatty Acid Beta-oxidation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Calcium Ion Import Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Positive Regulation Of Lipid Catabolic Process Response To Insulin Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Fatty Acid Oxidation Positive Regulation Of Glucose Metabolic Process Regulation Of Glycogen Metabolic Process Response To Growth Hormone Negative Regulation Of Transporter Activity Regulation Of ATPase Activity Negative Regulation Of Calcium Ion Transport Positive Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Glucose Import Regulation Of Ion Transmembrane Transport Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Glucose Transport Response To Peptide Hormone JAK-STAT Cascade Regulation Of Lipid Catabolic Process Response To Peptide Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Glucose Import Positive Regulation Of Stem Cell Proliferation Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Ion Transport Regulation Of Fatty Acid Metabolic Process Regulation Of Cellular Component Movement Regulation Of Glucose Transport Negative Regulation Of Binding Regulation Of Catalytic Activity Regulation Of Glucose Metabolic Process Regulation Of Stem Cell Proliferation	Relaxation Of Muscle Regulation Of Striated Muscle Contraction Chromosome Localization To Nuclear Envelope Involved In Synapsis Negative Regulation Of Calcium-transporting ATPase Activity Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Relaxation Of Skeletal Muscle Negative Regulation Of Calcium Ion Binding Maintenance Of Mitochondrion Location Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Regulation Of The Force Of Heart Contraction By Cardiac Conduction Regulation Of Muscle Contraction Chemical Homeostasis Cuticle Development Regulation Of Calcium-transporting ATPase Activity Adrenergic Receptor Signaling Pathway Involved In Heart Process Cornification G-protein Coupled Receptor Signaling Pathway Involved In Heart Process Establishment Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Calcium Ion Import Muscle System Process Regulation Of Relaxation Of Cardiac Muscle Cellular Calcium Ion Homeostasis Establishment Of Apical/basal Cell Polarity Negative Regulation Of Striated Muscle Contraction Polarized Epithelial Cell Differentiation Calcium Ion Homeostasis Calcium Ion Transport Negative Regulation Of ATPase Activity Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of Relaxation Of Muscle Homeostatic Process Regulation Of Skeletal Muscle Contraction Negative Regulation Of Heart Rate Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Establishment Of Monopolar Cell Polarity Positive Regulation Of Striated Muscle Contraction Relaxation Of Cardiac Muscle Cellular Metal Ion Homeostasis Organelle Localization Cellular Cation Homeostasis Adrenergic Receptor Signaling Pathway Tissue Development Cellular Ion Homeostasis Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Mitochondrial Calcium Ion Homeostasis Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Establishment Of Skin Barrier Establishment Of Epithelial Cell Polarity
Tagcloud ?			abr acoustic agno antioxidants brainstem centered cochlea cochleas counted edaravone entrapment exerted guinea hair hearing intratympanic khz nihl noise noticeable ohcs pigs prepare silvernitrate slns sound spl thresholds ultrasound
Tagcloud (Difference) ?			abr acoustic agno antioxidants brainstem centered cochlea cochleas counted edaravone entrapment exerted guinea hair hearing intratympanic khz nihl noise noticeable ohcs pigs prepare silvernitrate slns sound spl thresholds ultrasound
Tagcloud (Intersection) ?