MTHFR and LSM8

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
HPRD (two hybrid)

		MTHFR	LSM8
Gene Name		methylenetetrahydrofolate reductase (NAD(P)H)	LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Neuron Projection	Spliceosomal Complex U4/U6 X U5 Tri-snRNP Complex
	Molecular Function	Methylenetetrahydrofolate Reductase (NAD(P)H) Activity Flavin Adenine Dinucleotide Binding NADP Binding Modified Amino Acid Binding	Protein Binding U6 SnRNA Binding U6 SnRNA 3'-end Binding Poly(A) RNA Binding
	Biological Process	Response To Hypoxia Cellular Amino Acid Metabolic Process One-carbon Metabolic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Blood Circulation Methionine Biosynthetic Process Response To Vitamin B2 Tetrahydrofolate Interconversion Response To Drug Response To Amino Acid Small Molecule Metabolic Process S-adenosylmethionine Metabolic Process Folic Acid Metabolic Process Homocysteine Metabolic Process Response To Folic Acid Oxidation-reduction Process Response To Interleukin-1	MRNA Splicing, Via Spliceosome
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Metabolism of folate and pterines Defective TCN2 causes hereditary megaloblastic anemia Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism
Drugs		Cyanocobalamin Tetrahydrofolic acid
Diseases
GWAS		Atrial fibrillation ( 19597492) Blood pressure ( 21909110) Folate pathway vitamin levels ( 19744961) Homocysteine levels ( 20031578) Systolic blood pressure ( 19430483)
Protein-Protein Interactions		1 interactors: LSM8	49 interactors: ARNT BCKDK COL23A1 DBF4 DCP1A DCP1B DPAGT1 ECHDC2 EFTUD2 EXOSC10 EXOSC6 FAM63A FERMT3 GMPPA GTF2I HSPA9 IFNLR1 IGHMBP2 ISOC2 ITSN2 KCTD3 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 MGA MPRIP MRPL48 MTHFR NAGK NME4 PDCD2 PGD PHF11 RBM5 RPL24 RSC1A1 RSL24D1 SEPT10 SEPT5 SMU1 SNRNP200 SNRPB SNRPD1 TALDO1 THUMPD3 UPF1
Entrez ID		4524	51691
HPRD ID		06158	06288
Ensembl ID		ENSG00000177000
Uniprot IDs		P42898 Q59GJ6 Q5SNW6 Q8IU67	A4D0W0 O95777
PDB IDs
Enriched GO Terms of Interacting Partners?			Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process MRNA Metabolic Process MRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RNA Catabolic Process Nucleobase-containing Compound Metabolic Process Aromatic Compound Catabolic Process RNA Splicing Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process MRNA Processing RNA Processing Catabolic Process Gene Expression RNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cellular Macromolecule Catabolic Process Ribonucleoprotein Complex Biogenesis Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cellular Metabolic Process Histone MRNA Metabolic Process Pentose Biosynthetic Process Metabolic Process Histone MRNA Catabolic Process Dosage Compensation By Inactivation Of X Chromosome Spliceosomal Complex Assembly Dosage Compensation Ribonucleoprotein Complex Assembly Ribosome Biogenesis Pentose-phosphate Shunt Glyceraldehyde-3-phosphate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Glucose 6-phosphate Metabolic Process RRNA Processing NcRNA Metabolic Process Starch Catabolic Process Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Response To Type III Interferon Dolichol Biosynthetic Process NADP Metabolic Process RRNA Metabolic Process Spliceosomal SnRNP Assembly Carbohydrate Biosynthetic Process D-gluconate Metabolic Process Response To Vitamin B2
Tagcloud ?		1298cc 2756a 2756aa 2756ag 677t 677tt bc cypriot cyprus dietary folate greek highlighting mastos mediterranean micronutrients modifiers modify mtr orq4vs ors pca q1 resembles rs1801131 rs1801133 rs1805087 snps taqman
Tagcloud (Difference) ?		1298cc 2756a 2756aa 2756ag 677t 677tt bc cypriot cyprus dietary folate greek highlighting mastos mediterranean micronutrients modifiers modify mtr orq4vs ors pca q1 resembles rs1801131 rs1801133 rs1805087 snps taqman
Tagcloud (Intersection) ?