MTHFR and ZBTB17

Data Source: HiPPIP (Novel)

		MTHFR	ZBTB17
Name		methylenetetrahydrofolate reductase	zinc finger and BTB domain containing 17
Structure
GO Annotations	Cellular Component	Cytosol	Nucleus Nucleoplasm Protein-containing Complex Protein-DNA Complex
	Molecular Function	Catalytic Activity Methylenetetrahydrofolate Reductase [NAD(P)H] Activity Protein Binding Oxidoreductase Activity Protein-containing Complex Binding Flavin Adenine Dinucleotide Binding NADP Binding FAD Binding Modified Amino Acid Binding Methylenetetrahydrofolate Reductase (NADPH) Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Core Promoter Sequence-specific DNA Binding Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding DNA-binding Transcription Factor Binding
	Biological Process	Response To Hypoxia Neural Tube Closure Methionine Metabolic Process Methionine Biosynthetic Process Response To Xenobiotic Stimulus Response To Vitamin B2 Tetrahydrofolate Interconversion Response To Amino Acid S-adenosylmethionine Metabolic Process Tetrahydrofolate Metabolic Process Homocysteine Metabolic Process Response To Folic Acid Response To Interleukin-1 Heterochromatin Organization	Negative Regulation Of Transcription By RNA Polymerase II Gastrulation With Mouth Forming Second Regulation Of Cytokine Production Regulation Of Immune System Process Ectoderm Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II G1 To G0 Transition
Pathways		Metabolism of folate and pterines	XBP1(S) activates chaperone genes
Drugs		Cyanocobalamin Tetrahydrofolic acid	None
Diseases		Spina bifida Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Homocystinuria	None
GWAS		Atrial fibrillation ( 19597492 ) Blood pressure ( 21909110 ) Coronary artery disease ( 29212778 ) Diastolic blood pressure ( 29615537 28739976 27841878 27618452 ) Diastolic blood pressure (cigarette smoking interaction) ( 29455858 ) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962 ) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Early-onset schizophrenia ( 33907183 ) Folate pathway vitamin levels ( 19744961 ) High altitude adaptation ( 28373541 ) Hip index ( 34021172 ) Homocysteine levels ( 20031578 23696881 23824729 ) Hypertension ( 31879980 ) Mean arterial pressure ( 27618448 ) Mean corpuscular hemoglobin ( 32888494 ) Mean platelet volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Medication use (calcium channel blockers) ( 31015401 ) Midregional pro atrial natriuretic peptide levels ( 29237677 ) Moyamoya disease ( 29273593 ) Multiple sclerosis ( 31604244 ) Offspring birth weight ( 31043758 ) Plasma homocysteine levels ( 30339177 ) Pulse pressure ( 27841878 ) Red blood cell count ( 32888494 ) Red blood cell folate levels ( 30339177 ) Serum folate levels ( 29953918 30339177 ) Systolic blood pressure ( 27618452 28739976 19430483 27618447 27841878 ) Systolic blood pressure (cigarette smoking interaction) ( 29455858 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Tuberculosis ( 29036319 )	Dilated cardiomyopathy ( 33495596 ) Dilated cardiomyopathy (MTAG) ( 33495596 ) Erectile dysfunction ( 30583798 ) Glomerular filtration rate ( 29403010 ) Heel bone mineral density ( 30598549 ) Idiopathic dilated cardiomyopathy ( 21459883 )
Novel Interactors		7 novel interactors: DDX21 FHL2 MMP23B PRKCZ TP73 ZBTB17 ZNF239	2 novel interactors: MTHFR RERE
Interacting Genes		1 interacting genes: LSM8	28 interacting genes: BCL6 CDKN2B CREBBP DIS3 DNMT3A E2F6 EP300 ESR1 ESR2 GTF2I HCFC1 HK2 HK3 HSPB1 IRF8 ITGB5 MAX MSX2 MYC MYCN PGR TMPRSS11A TOPBP1 TRIM55 TRIM63 VHL ZBTB7C ZBTB8A
Entrez ID		4524	7709
HPRD ID		06158	04968
Ensembl ID		ENSG00000177000	ENSG00000116809
Uniprot IDs		A0A286YFD0 P42898 Q59GJ6 Q5SNW7 Q8IU67	Q13105 Q53EM1
PDB IDs		6FCX 8QA4 8QA5 8QA6	2LVR 2LVT 2LVU 2M0D 2M0E 2M0F 2N25 2N26 2Q81 3M52 4U2M 4U2N 5ION 7AZW 7AZX 7MC1 7MC2 7MC3 7T58
GO Terms Enriched among Interactors		None	Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Transcription Coactivator Binding Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Chromatin Organization DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Estrogen Response Element Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Response To Decreased Oxygen Levels Chromatin Chromatin Remodeling Regulation Of Gene Expression Response To Oxygen Levels Regulation Of Macromolecule Biosynthetic Process Histone H3K27 Acetyltransferase Activity Myc-Max Complex Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nuclear Steroid Receptor Activity Morphogenesis Of A Branching Structure Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Histone Acetyltransferase Complex Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process