LSM8 and IFNLR1

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
HPRD (two hybrid)

		LSM8	IFNLR1
Description		LSM8 homolog, U6 small nuclear RNA associated	interferon lambda receptor 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U6 SnRNP U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Lsm2-8 Complex Ribonucleoprotein Complex	Plasma Membrane Membrane Interleukin-28 Receptor Complex
	Molecular Function	RNA Binding MRNA Binding Protein Binding U6 SnRNA Binding	Cytokine Receptor Activity Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing	Mucosal Immune Response Negative Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Response To Type III Interferon Type III Interferon-mediated Signaling Pathway Regulation Of Defense Response To Virus By Host Defense Response To Virus Cellular Response To Virus Positive Regulation Of Cellular Respiration
Pathways		mRNA Splicing - Major Pathway	Other interleukin signaling Interleukin-20 family signaling
Drugs
Diseases
GWAS		Anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Glaucoma (primary open-angle) ( 29891935 33627673) Intraocular pressure ( 29617998) Plasma anti-thyroid peroxidase levels ( 29678681) Positive urgency ( 30718321) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Smoking initiation ( 33082346) Smoking status (current vs never) ( 33082346) Triglyceride levels ( 30108155)	Blood protein levels ( 30072576) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Inflammatory skin disease ( 25574825) Molybdenum levels ( 26025379) Psoriasis vulgaris ( 26626624)
Interacting Genes		49 interacting genes: ARNT BCKDK COL23A1 DBF4 DCP1A DCP1B DPAGT1 ECHDC2 EFTUD2 EXOSC10 EXOSC6 FERMT3 GMPPA GTF2I HSPA9 IFNLR1 IGHMBP2 ISOC2 ITSN2 KCTD3 LSM2 LSM3 LSM5 LSM6 LSM7 MAPK8IP2 MGA MINDY1 MPRIP MRPL48 MTHFR NAGK NME4 PDCD2 PGD PHF11 RBM5 RPL24 RSC1A1 RSL24D1 SEPTIN10 SEPTIN5 SMU1 SNRNP200 SNRPB SNRPD1 TALDO1 THUMPD3 UPF1	7 interacting genes: ANKRD46 BRICD5 CTXN3 IFNL1 IFNL2 LSM8 PAEP
Entrez ID		51691	163702
HPRD ID		06288	09589
Ensembl ID		ENSG00000128534	ENSG00000185436
Uniprot IDs		A4D0W0 O95777	Q8IU57
PDB IDs		3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG 8H6E 8H6J 8H6K 8H6L 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5	3OG4 3OG6 5IXD 5IXI 5L04 5T5W 9BPU 9BPV
Enriched GO Terms of Interacting Partners?		U2-type Precatalytic Spliceosome U4/U6 X U5 Tri-snRNP Complex Lsm2-8 Complex MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions U6 SnRNP MRNA Catabolic Process Spliceosomal Complex Lsm1-7-Pat1 Complex RNA Catabolic Process RNA Splicing Catalytic Step 2 Spliceosome Nucleobase-containing Compound Metabolic Process RNA Metabolic Process MRNA Processing RNA Processing RNA Binding Ribonucleoprotein Complex Small Nuclear Ribonucleoprotein Complex Precatalytic Spliceosome P-body Nucleobase-containing Compound Catabolic Process Nuclear-transcribed MRNA Catabolic Process Nucleic Acid Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Protein-RNA Complex Assembly Double-stranded DNA Helicase Activity U5 SnRNP Positive Regulation Of MRNA Cis Splicing, Via Spliceosome U12-type Spliceosomal Complex Deadenylation-independent Decapping Of Nuclear-transcribed MRNA U2-type Catalytic Step 2 Spliceosome Spliceosomal Tri-snRNP Complex U1 SnRNP Binding Nucleoplasm Poly(A)-dependent SnoRNA 3'-end Processing 7-methylguanosine Cap Hypermethylation Spliceosomal SnRNP Assembly Regulation Of MRNA Splicing, Via Spliceosome Spliceosomal Complex Assembly Nucleolar Exosome (RNase Complex) 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity Nuclear MRNA Surveillance U4 SnRNP Methylosome Macromolecule Metabolic Process Pentose-phosphate Shunt Regulation Of MRNA Processing Septin Ring	Type III Interferon-mediated Signaling Pathway Negative Regulation Of Sperm Capacitation Cell Surface Receptor Signaling Pathway Via JAK-STAT Cellular Response To Virus Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Interleukin-28 Receptor Binding Negative Regulation Of Memory T Cell Differentiation Interleukin-28 Receptor Complex Regulation Of Sperm Capacitation Regulation Of Binding Of Sperm To Zona Pellucida Positive Regulation Of MHC Class I Biosynthetic Process Lsm2-8 Complex Negative Regulation Of Interleukin-13 Production Regulation Of MHC Class I Biosynthetic Process Cytokine Activity Negative Regulation Of Interleukin-5 Production U6 SnRNP Negative Regulation Of Cell Development Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production U6 SnRNA Binding Regulation Of Memory T Cell Differentiation Defense Response To Virus Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Negative Regulation Of Type 2 Immune Response
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