LSM8 and MPRIP

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		LSM8	MPRIP
Gene Name		LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae)	myosin phosphatase Rho interacting protein
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Spliceosomal Complex U4/U6 X U5 Tri-snRNP Complex	Cytoplasm Focal Adhesion Actin Cytoskeleton
	Molecular Function	Protein Binding U6 SnRNA Binding U6 SnRNA 3'-end Binding Poly(A) RNA Binding	Actin Binding Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome
Pathways
Drugs
Diseases
GWAS			Diabetic retinopathy ( 21441570) Obesity-related traits ( 23251661)
Protein-Protein Interactions		49 interactors: ARNT BCKDK COL23A1 DBF4 DCP1A DCP1B DPAGT1 ECHDC2 EFTUD2 EXOSC10 EXOSC6 FAM63A FERMT3 GMPPA GTF2I HSPA9 IFNLR1 IGHMBP2 ISOC2 ITSN2 KCTD3 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 MGA MPRIP MRPL48 MTHFR NAGK NME4 PDCD2 PGD PHF11 RBM5 RPL24 RSC1A1 RSL24D1 SEPT10 SEPT5 SMU1 SNRNP200 SNRPB SNRPD1 TALDO1 THUMPD3 UPF1	13 interactors: ATXN7 IKBKG LSM8 NOS3 PIAS4 PPP1R12A PPP1R12C RACGAP1 RHOA YTHDC1 YWHAB YWHAG YWHAQ
Entrez ID		51691	23164
HPRD ID		06288	17591
Ensembl ID			ENSG00000133030
Uniprot IDs		A4D0W0 O95777	Q6WCQ1 Q8N236
PDB IDs
Enriched GO Terms of Interacting Partners?		Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process MRNA Metabolic Process MRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RNA Catabolic Process Nucleobase-containing Compound Metabolic Process Aromatic Compound Catabolic Process RNA Splicing Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process MRNA Processing RNA Processing Catabolic Process Gene Expression RNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cellular Macromolecule Catabolic Process Ribonucleoprotein Complex Biogenesis Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cellular Metabolic Process Histone MRNA Metabolic Process Pentose Biosynthetic Process Metabolic Process Histone MRNA Catabolic Process Dosage Compensation By Inactivation Of X Chromosome Spliceosomal Complex Assembly Dosage Compensation Ribonucleoprotein Complex Assembly Ribosome Biogenesis Pentose-phosphate Shunt Glyceraldehyde-3-phosphate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Glucose 6-phosphate Metabolic Process RRNA Processing NcRNA Metabolic Process Starch Catabolic Process Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Response To Type III Interferon Dolichol Biosynthetic Process NADP Metabolic Process RRNA Metabolic Process Spliceosomal SnRNP Assembly Carbohydrate Biosynthetic Process D-gluconate Metabolic Process Response To Vitamin B2	Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Signal Transduction Regulation Of Intracellular Transport Regulation Of Signaling Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Positive Regulation Of Intracellular Transport Regulation Of Cellular Localization Intracellular Signal Transduction Regulation Of Mitochondrion Organization Positive Regulation Of Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Protein Localization Regulation Of Apoptotic Process Positive Regulation Of Organelle Organization Regulation Of Phosphorus Metabolic Process Mitotic Spindle Assembly Regulation Of Cell Death Regulation Of Organelle Organization Microtubule Cytoskeleton Organization Intrinsic Apoptotic Signaling Pathway Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Substantia Nigra Development Positive Regulation Of Cytokinesis Small GTPase Mediated Signal Transduction Positive Regulation Of Cell Death Mitotic Spindle Organization Signaling Regulation Of Establishment Of Protein Localization Negative Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Process Cell Communication Neural Nucleus Development Positive Regulation Of Transport Mitotic Cell Cycle Regulation Of Cytokinesis Microtubule-based Process Mitotic Nuclear Division Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Cytokinesis, Initiation Of Separation Actomyosin Contractile Ring Assembly Regulation Of Catalytic Activity Apoptotic Signaling Pathway Spindle Assembly Positive Regulation Of Cellular Metabolic Process
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