MTHFR and MMP23B

		MTHFR	MMP23B
Description		methylenetetrahydrofolate reductase	matrix metallopeptidase 23B
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Extracellular Matrix
	Molecular Function	Catalytic Activity Methylenetetrahydrofolate Reductase [NAD(P)H] Activity Protein Binding Oxidoreductase Activity Protein-containing Complex Binding Flavin Adenine Dinucleotide Binding NADP Binding FAD Binding Modified Amino Acid Binding Methylenetetrahydrofolate Reductase (NADPH) Activity	Metalloendopeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Response To Hypoxia Neural Tube Closure Methionine Metabolic Process Methionine Biosynthetic Process Response To Xenobiotic Stimulus Response To Vitamin B2 Tetrahydrofolate Interconversion Response To Amino Acid S-adenosylmethionine Metabolic Process Tetrahydrofolate Metabolic Process Homocysteine Metabolic Process Response To Folic Acid Response To Interleukin-1 Heterochromatin Organization	Proteolysis Extracellular Matrix Organization Collagen Catabolic Process
Pathways		Metabolism of folate and pterines
Drugs		Cyanocobalamin Tetrahydrofolic acid	Marimastat
Diseases		Spina bifida Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Homocystinuria
GWAS		Atrial fibrillation ( 19597492) Blood pressure ( 21909110) Coronary artery disease ( 29212778) Diastolic blood pressure ( 29615537 28739976 27841878 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Early-onset schizophrenia ( 33907183) Folate pathway vitamin levels ( 19744961) High altitude adaptation ( 28373541) Hip index ( 34021172) Homocysteine levels ( 20031578 23696881 23824729) Hypertension ( 31879980) Mean arterial pressure ( 27618448) Mean corpuscular hemoglobin ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (calcium channel blockers) ( 31015401) Midregional pro atrial natriuretic peptide levels ( 29237677) Moyamoya disease ( 29273593) Multiple sclerosis ( 31604244) Offspring birth weight ( 31043758) Plasma homocysteine levels ( 30339177) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Red blood cell folate levels ( 30339177) Serum folate levels ( 29953918 30339177) Systolic blood pressure ( 27618452 28739976 19430483 27618447 27841878) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Tuberculosis ( 29036319)	Body mass index ( 26426971)
Interacting Genes		1 interacting genes: LSM8	2 interacting genes: GLRX SRPK2
Entrez ID		4524	8510
HPRD ID		06158	04503
Ensembl ID		ENSG00000177000	ENSG00000189409
Uniprot IDs		A0A286YFD0 P42898 Q59GJ6 Q5SNW7 Q8IU67	O75900
PDB IDs		6FCX 8QA4 8QA5 8QA6
Enriched GO Terms of Interacting Partners?			Glutathione Disulfide Oxidoreductase Activity Methylenetetrahydrofolate Reductase (NADPH) Activity Methylenetetrahydrofolate Reductase [NAD(P)H] Activity Response To Vitamin B2 Disulfide Oxidoreductase Activity Nucleobase-containing Small Molecule Interconversion Positive Regulation Of Membrane Potential Methionine Biosynthetic Process S-adenosylmethionine Metabolic Process Modified Amino Acid Binding Heterochromatin Organization Response To Folic Acid Tetrahydrofolate Interconversion R-loop Processing Nuclear Speck Organization Methionine Metabolic Process Homocysteine Metabolic Process Sulfur Amino Acid Biosynthetic Process Tetrahydrofolate Metabolic Process Nuclear Body Organization One-carbon Metabolic Process Folic Acid-containing Compound Metabolic Process Sodium Channel Regulator Activity Sulfur Amino Acid Metabolic Process Pteridine-containing Compound Metabolic Process 14-3-3 Protein Binding Positive Regulation Of Viral Genome Replication Aspartate Family Amino Acid Metabolic Process NADP Binding FAD Binding Anatomical Structure Formation Involved In Morphogenesis Chromatin Organization Peptidyl-serine Phosphorylation Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Flavin Adenine Dinucleotide Binding Positive Regulation Of Viral Process Amino Acid Biosynthetic Process
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