MTHFR

Description		methylenetetrahydrofolate reductase
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GO Annotations	Cellular Component	Cytosol
	Molecular Function	Catalytic Activity Methylenetetrahydrofolate Reductase [NAD(P)H] Activity Protein Binding Oxidoreductase Activity Protein-containing Complex Binding Flavin Adenine Dinucleotide Binding NADP Binding FAD Binding Modified Amino Acid Binding Methylenetetrahydrofolate Reductase (NADPH) Activity
	Biological Process	Response To Hypoxia Neural Tube Closure Methionine Metabolic Process Methionine Biosynthetic Process Response To Xenobiotic Stimulus Response To Vitamin B2 Tetrahydrofolate Interconversion Response To Amino Acid S-adenosylmethionine Metabolic Process Tetrahydrofolate Metabolic Process Homocysteine Metabolic Process Response To Folic Acid Response To Interleukin-1 Heterochromatin Organization
Pathways		Metabolism of folate and pterines
Drugs		Cyanocobalamin Tetrahydrofolic acid
Diseases		Spina bifida Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Homocystinuria
GWAS		Atrial fibrillation ( 19597492) Blood pressure ( 21909110) Coronary artery disease ( 29212778) Diastolic blood pressure ( 29615537 28739976 27841878 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Early-onset schizophrenia ( 33907183) Folate pathway vitamin levels ( 19744961) High altitude adaptation ( 28373541) Hip index ( 34021172) Homocysteine levels ( 20031578 23696881 23824729) Hypertension ( 31879980) Mean arterial pressure ( 27618448) Mean corpuscular hemoglobin ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (calcium channel blockers) ( 31015401) Midregional pro atrial natriuretic peptide levels ( 29237677) Moyamoya disease ( 29273593) Multiple sclerosis ( 31604244) Offspring birth weight ( 31043758) Plasma homocysteine levels ( 30339177) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Red blood cell folate levels ( 30339177) Serum folate levels ( 29953918 30339177) Systolic blood pressure ( 27618452 28739976 19430483 27618447 27841878) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Tuberculosis ( 29036319)
Novel Interacting Genes		7 novel interacting genes: DDX21 FHL2 MMP23B PRKCZ TP73 ZBTB17 ZNF239
Interacting Genes		1 interacting genes: LSM8
Entrez ID		4524
HPRD ID		06158
Ensembl ID		ENSG00000177000
Uniprot IDs		A0A286YFD0 P42898 Q59GJ6 Q5SNW7 Q8IU67
PDB IDs		6FCX 8QA4 8QA5 8QA6
Enriched GO Terms of Interacting Partners?
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