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MSX1 and TLE2
Number of citations of the paper that reports this interaction (PMID
20211142
)
148
Data Source:
BioGRID
(two hybrid)
MSX1
TLE2
Gene Name
msh homeobox 1
transducin-like enhancer of split 2
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Transcription Factor Complex
Cytoplasm
Extracellular Space
Nucleus
Nucleoplasm
Molecular Function
RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
P53 Binding
Transcription Corepressor Activity
Protein Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Cell Morphogenesis
In Utero Embryonic Development
Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Transcription From RNA Polymerase II Promoter
Muscle Organ Development
Negative Regulation Of Cell Proliferation
Anterior/posterior Pattern Specification
Mesenchymal Cell Proliferation
Pituitary Gland Development
Signal Transduction Involved In Regulation Of Gene Expression
Negative Regulation Of Cell Growth
Positive Regulation Of BMP Signaling Pathway
Midbrain Development
Protein Localization To Nucleus
Embryonic Forelimb Morphogenesis
Embryonic Hindlimb Morphogenesis
Embryonic Nail Plate Morphogenesis
Middle Ear Morphogenesis
Odontogenesis Of Dentin-containing Tooth
Regulation Of Odontogenesis
Negative Regulation Of Apoptotic Process
Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Protein Stabilization
Negative Regulation Of Striated Muscle Cell Differentiation
Palate Development
Face Morphogenesis
Bone Morphogenesis
Cartilage Morphogenesis
Mammary Gland Epithelium Development
BMP Signaling Pathway Involved In Heart Development
Cellular Response To Nicotine
Activation Of Meiosis
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Negative Regulation Of Transcription Regulatory Region DNA Binding
Positive Regulation Of Mesenchymal Cell Apoptotic Process
Transcription, DNA-templated
Signal Transduction
Notch Signaling Pathway
Organ Morphogenesis
Wnt Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways
Signaling by NOTCH1 HD Domain Mutants in Cancer
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
APC truncation mutants have impaired AXIN binding
misspliced GSK3beta mutants stabilize beta-catenin
T41 mutants of beta-catenin aren't phosphorylated
TCF7L2 mutants don't bind CTBP
truncated APC mutants destabilize the destruction complex
Signaling by Wnt
deactivation of the beta-catenin transactivating complex
APC truncation mutants are not K63 polyubiquitinated
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
S37 mutants of beta-catenin aren't phosphorylated
Degradation of beta-catenin by the destruction complex
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
RNF mutants show enhanced WNT signaling and proliferation
Signaling by NOTCH1
XAV939 inhibits tankyrase, stabilizing AXIN
Signaling by NOTCH1 in Cancer
truncations of AMER1 destabilize the destruction complex
FBXW7 Mutants and NOTCH1 in Cancer
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Signaling by NOTCH
formation of the beta-catenin:TCF transactivating complex
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
AXIN missense mutants destabilize the destruction complex
S45 mutants of beta-catenin aren't phosphorylated
repression of WNT target genes
NOTCH1 Intracellular Domain Regulates Transcription
deletions in the AMER1 gene destabilize the destruction complex
AMER1 mutants destabilize the destruction complex
TCF dependent signaling in response to WNT
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Signaling by WNT in cancer
Drugs
Diseases
GWAS
Congenital heart disease (
23708191
)
Electrocardiographic conduction measures (
19389651
)
Protein-Protein Interactions
24 interactors:
AES
CREBBP
DLX2
DLX5
HOXC8
ING4
LHX2
MED19
MSX2
NMNAT1
PAX3
PAX9
PIAS1
POU2F1
RGS7
SP1
SUMO1
SUMO2
TAF1
TBP
TLE1
TLE2
TLE4
TP53
16 interactors:
BARHL1
EMX2
FOXA3
H3F3A
HES1
HMGB1
LEF1
MSX1
MSX2
PAX9
PRDM1
RUNX1
TLE1
TLX3
UTY
VENTX
Entrez ID
4487
7089
HPRD ID
00866
03025
Ensembl ID
ENSG00000163132
ENSG00000065717
Uniprot IDs
P28360
B4DE62
K7EMK7
Q04725
PDB IDs
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Transcription From RNA Polymerase II Promoter
Regulation Of Transcription From RNA Polymerase II Promoter
Transcription, DNA-templated
RNA Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Gene Expression
Negative Regulation Of Cellular Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Macromolecule Biosynthetic Process
RNA Metabolic Process
Gene Expression
Nitrogen Compound Metabolic Process
Regulation Of Metabolic Process
Biosynthetic Process
Positive Regulation Of Gene Expression
Organ Morphogenesis
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Macromolecule Biosynthetic Process
Embryonic Morphogenesis
Positive Regulation Of Metabolic Process
Anatomical Structure Morphogenesis
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Peptidyl-lysine Modification
Notch Signaling Pathway
Pattern Specification Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Metabolic Process
Positive Regulation Of Proteasomal Protein Catabolic Process
Embryo Development
Organ Development
Regulation Of Cellular Process
Protein Sumoylation
Negative Regulation Of Binding
Regulation Of Signal Transduction
Regulation Of Gene Expression
Transcription From RNA Polymerase II Promoter
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of DNA Binding
Positive Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Multicellular Organismal Development
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
System Development
Organ Morphogenesis
Developmental Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Organ Development
Transcription, DNA-templated
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Anatomical Structure Development
RNA Biosynthetic Process
Anterior/posterior Pattern Specification
Cell Migration
Regulation Of Binding
Positive Regulation Of Transcription, DNA-templated
Cell Motility
Mesenchymal Cell Development
Cell Differentiation
Positive Regulation Of Mesenchymal Cell Apoptotic Process
Embryonic Nail Plate Morphogenesis
Gene Expression
Central Nervous System Development
Odontogenesis
Mesenchymal Cell Differentiation
Face Morphogenesis
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of BMP Signaling Pathway
Nucleobase-containing Compound Metabolic Process
Activation Of Meiosis
Generation Of Neurons
Head Morphogenesis
Positive Regulation Of Cellular Biosynthetic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Tagcloud
?
anomalies
cleft
clefts
cnv
cnvs
comprise
disrupting
doi
etiology
fgf8
foxe1
gli2
grouped
highlighting
irf6
jhg
journal
kif7
lip
mentioned
msx2
ofc
ofcs
orofacial
palate
postulated
satb2
ski
tceb3
Tagcloud (Difference)
?
anomalies
cleft
clefts
cnv
cnvs
comprise
disrupting
doi
etiology
fgf8
foxe1
gli2
grouped
highlighting
irf6
jhg
journal
kif7
lip
mentioned
msx2
ofc
ofcs
orofacial
palate
postulated
satb2
ski
tceb3
Tagcloud (Intersection)
?