MSX1 and POU2F1

Number of citations: 80 (PubMedID 16002402)
Data Source: HPRD (in vitro)

		MSX1	POU2F1
Name		msh homeobox 1	POU class 2 homeobox 1
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nuclear Periphery	Chromatin Nucleus Nucleoplasm Endoplasmic Reticulum RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding DNA Binding Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis In Utero Embryonic Development Epithelial To Mesenchymal Transition Heart Morphogenesis Cardiac Conduction System Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Heart Development Muscle Organ Development Negative Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Anterior/posterior Pattern Specification Mesenchymal Cell Proliferation Negative Regulation Of Gene Expression Pituitary Gland Development Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Cell Growth Embryonic Limb Morphogenesis BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Forebrain Development Midbrain Development Protein Localization To Nucleus Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Embryonic Nail Plate Morphogenesis Middle Ear Morphogenesis Odontogenesis Of Dentin-containing Tooth Odontogenesis Regulation Of Odontogenesis Positive Regulation Of Odontogenesis Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Nose Development Positive Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Morphogenesis Inner Ear Development Stem Cell Differentiation Protein Stabilization Negative Regulation Of Striated Muscle Cell Differentiation Cartilage Development Roof Of Mouth Development Face Morphogenesis Bone Morphogenesis Cartilage Morphogenesis Mammary Gland Epithelium Development Cell Surface Receptor Signaling Pathway Involved In Heart Development Cellular Response To Nicotine Activation Of Meiosis Mesenchymal Cell Apoptotic Process Negative Regulation Of Odontoblast Differentiation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Mesenchymal Cell Apoptotic Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of MiRNA Transcription
Pathways		Specification of the neural plate border	Interleukin-4 and Interleukin-13 signaling RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter Estrogen-dependent gene expression
Diseases		Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Tooth and nail syndrome; Witkop syndrome Tooth agenesis; Hypodontia	None
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Breast cancer and/or colorectal cancer ( 29698419 ) Congenital heart disease ( 23708191 ) Electrocardiographic conduction measures ( 19389651 ) Nonsyndromic cleft lip with cleft palate ( 28232668 )	Asthma ( 31619474 31959851 ) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444 ) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444 ) Diastolic blood pressure ( 30224653 ) Liver enzyme levels ( 18940312 ) Pre-treatment viral load in HIV-1 infection ( 31219150 )
Interacting Genes		25 interacting genes: CREBBP DLX2 DLX5 HOXC8 ING4 LHX2 MED19 MSX2 NMNAT1 PAX3 PAX9 PIAS1 POU2F1 RBPMS RGS7 SP1 SUMO1 SUMO2 TAF1 TBP TLE1 TLE2 TLE4 TLE5 TP53	67 interacting genes: APP AR ARPC3 ARRB1 BARD1 BRCA1 CEBPE CREB1 CREM ESR1 FDXR HCFC1 HIVEP1 HMGA1 HMGB2 HNF1A HOXB13 HOXC9 IRF9 LIFR MLLT10 MNAT1 MSX1 NCOR2 NFYA NPAT NR3C1 PARP1 PBX1 PGR PKNOX1 PLK3 POGZ POU2AF1 POU6F2 PPIP5K2 PRKACA PRKDC PRR20B PRR20C PRR20D PRR20E RARA RELA RXRA SNAPC4 SNIP1 SNX24 SOX2 SP1 SP4 STAT5A STAT5B STOX1 TBP THRA TLE4 TLE5 TLX2 TNF TXNRD1 UBE2I VDR XRCC6 ZC3H10 ZFHX3 ZMYM6
Entrez ID		4487	5451
HPRD ID		00866	01250
Ensembl ID		ENSG00000163132	ENSG00000143190
Uniprot IDs		P28360	A0A8A2IE78 P14859
PDB IDs		Not available	1CQT 1E3O 1GT0 1HF0 1O4X 1OCT 1POG 1POU
GO Terms Enriched among Interactors		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Chromatin Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Nucleoplasm Transcription Regulator Complex Transcription Cis-regulatory Region Binding Transcription Corepressor Activity Negative Regulation Of Transcription By RNA Polymerase II Animal Organ Morphogenesis RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription Initiation By RNA Polymerase II RNA Polymerase II Core Promoter Sequence-specific DNA Binding Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II DNA-binding Transcription Factor Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription Initiation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Presynaptic Cytosol Postsynaptic Cytosol	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin DNA Binding Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Nucleus Positive Regulation Of Metabolic Process Nucleoplasm Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Regulation Of Metabolic Process Sequence-specific DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Metabolic Process Enzyme Binding Sequence-specific Double-stranded DNA Binding Nuclear Receptor Activity Gland Development Nucleobase-containing Compound Biosynthetic Process Nucleic Acid Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Rhythmic Process Regulation Of MiRNA Transcription