MSX1 and HOXC8

Number of citations of the paper that reports this interaction (PMID 9111364)
61

Data Source:
BioGRID (pull down)

		MSX1	HOXC8
Gene Name		msh homeobox 1	homeobox C8
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm	Nucleoplasm Microtubule Cytoskeleton
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription P53 Binding	Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis In Utero Embryonic Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Transcription From RNA Polymerase II Promoter Muscle Organ Development Negative Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Mesenchymal Cell Proliferation Pituitary Gland Development Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Cell Growth Positive Regulation Of BMP Signaling Pathway Midbrain Development Protein Localization To Nucleus Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Embryonic Nail Plate Morphogenesis Middle Ear Morphogenesis Odontogenesis Of Dentin-containing Tooth Regulation Of Odontogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Stabilization Negative Regulation Of Striated Muscle Cell Differentiation Palate Development Face Morphogenesis Bone Morphogenesis Cartilage Morphogenesis Mammary Gland Epithelium Development BMP Signaling Pathway Involved In Heart Development Cellular Response To Nicotine Activation Of Meiosis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Mesenchymal Cell Apoptotic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Anterior/posterior Pattern Specification Neuron Differentiation Skeletal System Morphogenesis
Pathways
Drugs
Diseases
GWAS		Congenital heart disease ( 23708191) Electrocardiographic conduction measures ( 19389651)
Protein-Protein Interactions		24 interactors: AES CREBBP DLX2 DLX5 HOXC8 ING4 LHX2 MED19 MSX2 NMNAT1 PAX3 PAX9 PIAS1 POU2F1 RGS7 SP1 SUMO1 SUMO2 TAF1 TBP TLE1 TLE2 TLE4 TP53	11 interactors: BMPR1A BTG2 DLX2 DLX5 GMNN HOMEZ JUN MSX1 SMAD1 SMAD4 SMAD6
Entrez ID		4487	3224
HPRD ID		00866	00856
Ensembl ID		ENSG00000163132
Uniprot IDs		P28360	P31273
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process RNA Metabolic Process Gene Expression Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Biosynthetic Process Positive Regulation Of Gene Expression Organ Morphogenesis Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Embryonic Morphogenesis Positive Regulation Of Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-lysine Modification Notch Signaling Pathway Pattern Specification Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Embryo Development Organ Development Regulation Of Cellular Process Protein Sumoylation Negative Regulation Of Binding Regulation Of Signal Transduction	BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Pattern Specification Process Transforming Growth Factor Beta Receptor Signaling Pathway Tissue Development Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Organ Development Regulation Of RNA Metabolic Process Response To Transforming Growth Factor Beta Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Proliferation Regulation Of Gene Expression Endocardial Cushion Formation Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Organ Morphogenesis Endocardial Cushion Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus Response To Growth Factor Epithelium Development Palate Development Embryonic Morphogenesis Embryo Development Negative Regulation Of Cell Proliferation System Development Endocardial Cushion Development Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Head Development RNA Metabolic Process Nervous System Development Multicellular Organismal Development Cell Differentiation Gene Expression Anatomical Structure Development Cartilage Development Generation Of Neurons Regulation Of Cell Differentiation
Tagcloud ?		anomalies cleft clefts cnv cnvs comprise disrupting doi etiology fgf8 foxe1 gli2 grouped highlighting irf6 jhg journal kif7 lip mentioned msx2 ofc ofcs orofacial palate postulated satb2 ski tceb3	abrogates cdkn1b correlates cyclophilin33 cyp33 downregulation h3k4me3 h4 homeodomain hoxa9 implying isomerase lineage lost mediates mll mutually phd3 preferentially proline reinsertion repression rrm selectivity structurally switch transforming translocations trimethylated
Tagcloud (Difference) ?		anomalies cleft clefts cnv cnvs comprise disrupting doi etiology fgf8 foxe1 gli2 grouped highlighting irf6 jhg journal kif7 lip mentioned msx2 ofc ofcs orofacial palate postulated satb2 ski tceb3	abrogates cdkn1b correlates cyclophilin33 cyp33 downregulation h3k4me3 h4 homeodomain hoxa9 implying isomerase lineage lost mediates mll mutually phd3 preferentially proline reinsertion repression rrm selectivity structurally switch transforming translocations trimethylated
Tagcloud (Intersection) ?