MSX1 and LHX2

Number of citations: 0 (PubMedID 9697309)
Data Source: HPRD (in vitro)

		MSX1	LHX2
Name		msh homeobox 1	LIM homeobox 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nuclear Periphery	Chromatin Nucleus
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding DNA Binding Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis In Utero Embryonic Development Epithelial To Mesenchymal Transition Heart Morphogenesis Cardiac Conduction System Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Heart Development Muscle Organ Development Negative Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Anterior/posterior Pattern Specification Mesenchymal Cell Proliferation Negative Regulation Of Gene Expression Pituitary Gland Development Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Cell Growth Embryonic Limb Morphogenesis BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Forebrain Development Midbrain Development Protein Localization To Nucleus Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Embryonic Nail Plate Morphogenesis Middle Ear Morphogenesis Odontogenesis Of Dentin-containing Tooth Odontogenesis Regulation Of Odontogenesis Positive Regulation Of Odontogenesis Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Nose Development Positive Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Morphogenesis Inner Ear Development Stem Cell Differentiation Protein Stabilization Negative Regulation Of Striated Muscle Cell Differentiation Cartilage Development Roof Of Mouth Development Face Morphogenesis Bone Morphogenesis Cartilage Morphogenesis Mammary Gland Epithelium Development Cell Surface Receptor Signaling Pathway Involved In Heart Development Cellular Response To Nicotine Activation Of Meiosis Mesenchymal Cell Apoptotic Process Negative Regulation Of Odontoblast Differentiation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Mesenchymal Cell Apoptotic Process	Neural Tube Closure Hair Follicle Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Axon Guidance Brain Development Mesoderm Development Dorsal/ventral Pattern Formation Telencephalon Development Olfactory Bulb Development Telencephalon Regionalization Cerebral Cortex Development Neurogenesis Neuron Differentiation Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Formation Involved In Morphogenesis Axon Extension Negative Regulation Of Neurogenesis Retina Development In Camera-type Eye Positive Regulation Of Neural Precursor Cell Proliferation
Pathways		Specification of the neural plate border	Regulation of expression of SLITs and ROBOs Expression and translocation of olfactory receptors
Diseases		Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Tooth and nail syndrome; Witkop syndrome Tooth agenesis; Hypodontia	None
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Breast cancer and/or colorectal cancer ( 29698419 ) Congenital heart disease ( 23708191 ) Electrocardiographic conduction measures ( 19389651 ) Nonsyndromic cleft lip with cleft palate ( 28232668 )	Asthma exacerbations in inhaled corticosteroid treatment ( 30697902 ) Blond vs. brown/black hair color ( 30531825 ) Depression ( 29700475 ) Hair color ( 29662168 ) Mercury levels ( 26025379 ) Post-traumatic stress disorder ( 25456346 ) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355 ) Waist circumference ( 23966867 )
Interacting Genes		25 interacting genes: CREBBP DLX2 DLX5 HOXC8 ING4 LHX2 MED19 MSX2 NMNAT1 PAX3 PAX9 PIAS1 POU2F1 RBPMS RGS7 SP1 SUMO1 SUMO2 TAF1 TBP TLE1 TLE2 TLE4 TLE5 TP53	30 interacting genes: ANKS1A ARHGAP32 BEND2 CITED2 DNMT3L FLYWCH1 HOMER3 HOXC8 KHK LGALSL LNX1 LONRF1 MORF4L1 MORN3 MSX1 NFIA NFIB NFIC OSMR PAX6 POU4F2 PPIL1 RLIM TCEANC TCP11L1 TLK1 TRAPPC2L UBTFL1 ZFP42 ZNF511
Entrez ID		4487	9355
HPRD ID		00866	04786
Ensembl ID		ENSG00000163132	ENSG00000106689
Uniprot IDs		P28360	B3KNJ5 P50458
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Chromatin Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Nucleoplasm Transcription Regulator Complex Transcription Cis-regulatory Region Binding Transcription Corepressor Activity Negative Regulation Of Transcription By RNA Polymerase II Animal Organ Morphogenesis RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription Initiation By RNA Polymerase II RNA Polymerase II Core Promoter Sequence-specific DNA Binding Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II DNA-binding Transcription Factor Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription Initiation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Presynaptic Cytosol Postsynaptic Cytosol	Glial Cell Fate Specification Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Retina Development In Camera-type Eye Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Animal Organ Development Regulation Of Transcription By RNA Polymerase II DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Gene Expression Forebrain Development Regulation Of Timing Of Cell Differentiation Regulation Of Development, Heterochronic Exit From Mitosis Embryonic Camera-type Eye Morphogenesis Negative Regulation Of Biosynthetic Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Synapse Maturation Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription BMP Signaling Pathway Response To Wounding Sequence-specific Double-stranded DNA Binding Nucleus DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cell Fate Specification Regulation Of Primary Metabolic Process Generation Of Neurons Regulation Of Macromolecule Metabolic Process Neural Precursor Cell Proliferation Anatomical Structure Morphogenesis Regulation Of Chromatin Organization Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of RNA Metabolic Process Transcription Regulator Complex DNA-templated Transcription Histone Acetyltransferase Binding Embryonic Eye Morphogenesis