MSX1 and LHX2

Number of citations of the paper that reports this interaction (PMID 9697309)
10

Data Source:
HPRD (in vitro)

		MSX1	LHX2
Gene Name		msh homeobox 1	LIM homeobox 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm	Nucleus
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription P53 Binding	RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Chromatin Binding Zinc Ion Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis In Utero Embryonic Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Transcription From RNA Polymerase II Promoter Muscle Organ Development Negative Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Mesenchymal Cell Proliferation Pituitary Gland Development Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Cell Growth Positive Regulation Of BMP Signaling Pathway Midbrain Development Protein Localization To Nucleus Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Embryonic Nail Plate Morphogenesis Middle Ear Morphogenesis Odontogenesis Of Dentin-containing Tooth Regulation Of Odontogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Stabilization Negative Regulation Of Striated Muscle Cell Differentiation Palate Development Face Morphogenesis Bone Morphogenesis Cartilage Morphogenesis Mammary Gland Epithelium Development BMP Signaling Pathway Involved In Heart Development Cellular Response To Nicotine Activation Of Meiosis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Mesenchymal Cell Apoptotic Process	Neural Tube Closure Transcription From RNA Polymerase II Promoter Axon Guidance Mesoderm Development Dorsal/ventral Pattern Formation Olfactory Bulb Development Telencephalon Regionalization Cerebral Cortex Development Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Axon Extension Retina Development In Camera-type Eye Negative Regulation Of Transcription Regulatory Region DNA Binding
Pathways
Drugs
Diseases
GWAS		Congenital heart disease ( 23708191) Electrocardiographic conduction measures ( 19389651)
Protein-Protein Interactions		24 interactors: AES CREBBP DLX2 DLX5 HOXC8 ING4 LHX2 MED19 MSX2 NMNAT1 PAX3 PAX9 PIAS1 POU2F1 RGS7 SP1 SUMO1 SUMO2 TAF1 TBP TLE1 TLE2 TLE4 TP53	5 interactors: CITED2 LDB1 MSX1 PAX6 RLIM
Entrez ID		4487	9355
HPRD ID		00866	04786
Ensembl ID		ENSG00000163132	ENSG00000106689
Uniprot IDs		P28360	B3KNJ5 P50458
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process RNA Metabolic Process Gene Expression Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Biosynthetic Process Positive Regulation Of Gene Expression Organ Morphogenesis Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Embryonic Morphogenesis Positive Regulation Of Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-lysine Modification Notch Signaling Pathway Pattern Specification Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Embryo Development Organ Development Regulation Of Cellular Process Protein Sumoylation Negative Regulation Of Binding Regulation Of Signal Transduction	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Pattern Specification Process Axis Specification Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Mesenchyme Development Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Stem Cell Development Anterior/posterior Pattern Specification Positive Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Involved In Regulation Of Gene Expression Anatomical Structure Formation Involved In Morphogenesis Epithelium Development Stem Cell Differentiation Embryo Development Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Pituitary Gland Development Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Embryonic Organ Development Cellular Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Gland Development Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Tissue Development Diencephalon Development Embryonic Morphogenesis Regulation Of Transcription, DNA-templated Histone H3-K4 Acetylation Pancreatic A Cell Development Forebrain-midbrain Boundary Formation Regulation Of Transcription From RNA Polymerase II Promoter Involved In Somatic Motor Neuron Fate Commitment Random Inactivation Of X Chromosome Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cerebellum Development Mesenchymal Cell Development Regulation Of RNA Metabolic Process Cell Proliferation Metencephalon Development
Tagcloud ?		anomalies cleft clefts cnv cnvs comprise disrupting doi etiology fgf8 foxe1 gli2 grouped highlighting irf6 jhg journal kif7 lip mentioned msx2 ofc ofcs orofacial palate postulated satb2 ski tceb3	ablated conditionally cuboid delete displaying embryonically ependymal expresses homeodomain hypothalamic intersectional isl lim lin mec multiciliated neuroepithelium posteroventral postnatally radial rarres2 rax retaining specification specifying sustaining tanycyte tanycytes ultrastructural
Tagcloud (Difference) ?		anomalies cleft clefts cnv cnvs comprise disrupting doi etiology fgf8 foxe1 gli2 grouped highlighting irf6 jhg journal kif7 lip mentioned msx2 ofc ofcs orofacial palate postulated satb2 ski tceb3	ablated conditionally cuboid delete displaying embryonically ependymal expresses homeodomain hypothalamic intersectional isl lim lin mec multiciliated neuroepithelium posteroventral postnatally radial rarres2 rax retaining specification specifying sustaining tanycyte tanycytes ultrastructural
Tagcloud (Intersection) ?