MSN and TRIM15

Number of citations of the paper that reports this interaction (PubMedID 25450970)
0

Data Source:
BioGRID (protein complementation assay)

		MSN	TRIM15
Description		moesin	tripartite motif containing 15
Image
GO Annotations	Cellular Component	Uropod Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Microvillus Adherens Junction Focal Adhesion Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Filopodium Pseudopodium Microvillus Membrane Vesicle Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Blood Microparticle	Nucleus Cytoplasm Focal Adhesion Anchoring Junction
	Molecular Function	Double-stranded RNA Binding Actin Binding Signaling Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Enzyme Binding Protein Kinase Binding Cell Adhesion Molecule Binding	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Molecular Sequestering Activity
	Biological Process	Immunological Synapse Formation Cytoskeleton Organization Leukocyte Cell-cell Adhesion Regulation Of Cell Shape Regulation Of Cell Size Positive Regulation Of Gene Expression Gland Morphogenesis Membrane To Membrane Docking T Cell Proliferation Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Protein Catabolic Process Leukocyte Migration Establishment Of Endothelial Barrier T Cell Aggregation Positive Regulation Of Podosome Assembly T Cell Migration Regulation Of Organelle Assembly Positive Regulation Of Protein Localization To Early Endosome Regulation Of Lymphocyte Migration Positive Regulation Of Early Endosome To Late Endosome Transport	Canonical NF-kappaB Signal Transduction Mesodermal Cell Fate Determination Positive Regulation Of Type I Interferon Production Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA-templated Transcription Protein K63-linked Ubiquitination Positive Regulation Of RIG-I Signaling Pathway Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Intracellular Transport Of Viral Material
Pathways		Recycling pathway of L1 Recycling pathway of L1 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea Signaling by ALK fusions and activated point mutants
Drugs
Diseases
GWAS		Male-pattern baldness ( 28196072)	Anger ( 24489884) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease ( 33909500) Hemoglobin ( 32888494) Mean corpuscular hemoglobin ( 32888494) Neurociticism ( 29500382) Neuroticism ( 29255261) Red cell distribution width ( 32888494) Tonsillitis ( 30037793)
Interacting Genes		31 interacting genes: BCAP31 CD46 CD93 CDK11B CEBPA ERBB2 EZR ICAM1 ICAM2 ICAM3 L1CAM LINC01554 LMO2 MYBPC2 NCF1 NCF4 NHERF1 PLEC PPM1A PPM1B PRKCQ ROCK1 SELL SELPLG SMURF1 SPN TERF1 TRIM15 TSC1 VCAM1 VPS11	42 interacting genes: ACD ACTB APOA1 AXIN1 CDK6 CFL1 CORO1B CTTN EHMT1 FAM151B FAM161A FAM161B FBLIM1 FERMT2 FERMT3 GAB1 GTF2E1 IRF5 KEAP1 MAPK3 MED7 MSN MYBL2 NEXN PFN1 PRNP PTK2 PXN RABGEF1 ROCK1 SHC1 SNW1 SYK TAF9B TINF2 TRIM8 UBE2N UBE2U VASP VCL VIM YJU2
Entrez ID		4478	89870
HPRD ID		02399	15551
Ensembl ID		ENSG00000147065	ENSG00000204610
Uniprot IDs		P26038 V9HWC0	Q5SRL0 Q9C019
PDB IDs		1E5W 1EF1 1SGH 6TXQ 6TXS 8CIR 8CIS 8CIT 8CIU	7QS2
Enriched GO Terms of Interacting Partners?		Leukocyte Cell-cell Adhesion Membrane To Membrane Docking Leukocyte Tethering Or Rolling Leukocyte Adhesion To Vascular Endothelial Cell Cell-cell Adhesion Cell Adhesion Uropod Plasma Membrane Microvillus Membrane Docking Immune System Process Negative Regulation Of Signal Transduction Leukocyte Activation Negative Regulation Of Cell Communication Negative Regulation Of Signaling Focal Adhesion Phagolysosome N-terminal Protein Myristoylation Regulation Of T Cell Proliferation Cell Activation Membrane Cell Migration Cell Periphery Positive Regulation Of Cell Adhesion Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Plasma Membrane Raft Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of T Cell Proliferation Activin Receptor Binding Protein Domain Specific Binding Protein Localization To Cell Periphery Leukocyte Migration Microvillus Assembly Negative Regulation Of Intracellular Signal Transduction Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Immunological Synapse Microvillus Organization Regulation Of Mononuclear Cell Proliferation Cell Motility Superoxide-generating NADPH Oxidase Activator Activity Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Intracellular Transport Regulation Of Leukocyte Proliferation Integrin Binding Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Cell Surface Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Lymphocyte Activation	Focal Adhesion Cytoskeleton Regulation Of Cellular Component Organization Anchoring Junction Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Actin Filament Organization Regulation Of Locomotion Cellular Component Assembly Positive Regulation Of Organelle Organization Regulation Of Cell Motility Cytosol Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cellular Component Organization Actin Binding Regulation Of Cell Adhesion Regulation Of Actin Filament-based Process Positive Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cellular Component Biogenesis Lamellipodium Regulation Of Cell-matrix Adhesion Regulation Of Focal Adhesion Assembly Regulation Of Cell-substrate Adhesion Cell Projection Organization Regulation Of Cell-substrate Junction Organization Positive Regulation Of Intracellular Signal Transduction Actin Cytoskeleton Organization Stress Fiber Regulation Of Cell Migration Cell-cell Adhesion Cytoskeleton Organization Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Metabolic Process Regulation Of Stress Fiber Assembly Integrin-mediated Signaling Pathway Cell Cortex Actin Filament-based Process Regulation Of Multicellular Organismal Process Cell Adhesion Cell Motility Regulation Of Developmental Process Negative Regulation Of Cellular Component Organization Plasma Membrane Bounded Cell Projection Organization Phosphotyrosine Residue Binding Regulation Of Protein-containing Complex Assembly Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein-containing Complex Assembly Leukocyte Cell-cell Adhesion
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