MSN and CD46

Number of citations of the paper that reports this interaction (PubMedID 12082081)
52

Data Source:
HPRD (in vivo, in vitro)

		MSN	CD46
Description		moesin	CD46 molecule
Image
GO Annotations	Cellular Component	Uropod Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Microvillus Adherens Junction Focal Adhesion Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Filopodium Pseudopodium Microvillus Membrane Vesicle Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Blood Microparticle	Inner Acrosomal Membrane Extracellular Space Plasma Membrane Focal Adhesion Cell Surface Membrane Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Double-stranded RNA Binding Actin Binding Signaling Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Enzyme Binding Protein Kinase Binding Cell Adhesion Molecule Binding	Virus Receptor Activity Protein Binding Signaling Receptor Activity Cadherin Binding
	Biological Process	Immunological Synapse Formation Cytoskeleton Organization Leukocyte Cell-cell Adhesion Regulation Of Cell Shape Regulation Of Cell Size Positive Regulation Of Gene Expression Gland Morphogenesis Membrane To Membrane Docking T Cell Proliferation Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Protein Catabolic Process Leukocyte Migration Establishment Of Endothelial Barrier T Cell Aggregation Positive Regulation Of Podosome Assembly T Cell Migration Regulation Of Organelle Assembly Positive Regulation Of Protein Localization To Early Endosome Regulation Of Lymphocyte Migration Positive Regulation Of Early Endosome To Late Endosome Transport	Adaptive Immune Response Immune System Process T Cell Mediated Immunity Complement Activation, Classical Pathway Single Fertilization Regulation Of Notch Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Interleukin-10 Production Sequestering Of Extracellular Ligand From Receptor Positive Regulation Of T Cell Proliferation Positive Regulation Of Memory T Cell Differentiation Innate Immune Response Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Complement Activation, Classical Pathway Symbiont Entry Into Host Cell Regulation Of Immune Response Positive Regulation Of Transforming Growth Factor Beta Production
Pathways		Recycling pathway of L1 Recycling pathway of L1 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea Signaling by ALK fusions and activated point mutants	Regulation of Complement cascade
Drugs
Diseases
GWAS		Male-pattern baldness ( 28196072)	Age-related macular degeneration ( 23326517) Biomedical quantitative traits ( 19396169) Chronic central serous retinopathy ( 30073298) Drug experimentation measurement ( 30718321) Early age-related macular degeneration ( 32843070) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Febrile seizures ( 25344690) Febrile seizures (MMR vaccine-related) ( 25344690) Heart rate ( 23583979) Immune response to measles vaccine (measles-specific neutralising antibody titre) ( 28289848) Keratoconus ( 33649486) Obesity-related traits ( 23251661) Pulse pressure ( 27841878) Refractive error ( 32231278) Resting heart rate ( 29769521 27798624) Schizophrenia ( 29483656 25056061) Systolic blood pressure ( 27841878 30578418) White blood cell count ( 32888494)
Interacting Genes		31 interacting genes: BCAP31 CD46 CD93 CDK11B CEBPA ERBB2 EZR ICAM1 ICAM2 ICAM3 L1CAM LINC01554 LMO2 MYBPC2 NCF1 NCF4 NHERF1 PLEC PPM1A PPM1B PRKCQ ROCK1 SELL SELPLG SMURF1 SPN TERF1 TRIM15 TSC1 VCAM1 VPS11	14 interacting genes: AGR3 ANKRD46 C3 DLG4 GPR37L1 ITGB1 LLGL1 MGAT5B MSN POU4F2 SRC TSPAN4 VTI1B YES1
Entrez ID		4478	4179
HPRD ID		02399	00406
Ensembl ID		ENSG00000147065	ENSG00000117335
Uniprot IDs		P26038 V9HWC0	A0A8Q3WLA6 P15529
PDB IDs		1E5W 1EF1 1SGH 6TXQ 6TXS 8CIR 8CIS 8CIT 8CIU	1CKL 2O39 3INB 3L89 3O8E 5FO8 8QK3
Enriched GO Terms of Interacting Partners?		Leukocyte Cell-cell Adhesion Membrane To Membrane Docking Leukocyte Tethering Or Rolling Leukocyte Adhesion To Vascular Endothelial Cell Cell-cell Adhesion Cell Adhesion Uropod Plasma Membrane Microvillus Membrane Docking Immune System Process Negative Regulation Of Signal Transduction Leukocyte Activation Negative Regulation Of Cell Communication Negative Regulation Of Signaling Focal Adhesion Phagolysosome N-terminal Protein Myristoylation Regulation Of T Cell Proliferation Cell Activation Membrane Cell Migration Cell Periphery Positive Regulation Of Cell Adhesion Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Plasma Membrane Raft Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of T Cell Proliferation Activin Receptor Binding Protein Domain Specific Binding Protein Localization To Cell Periphery Leukocyte Migration Microvillus Assembly Negative Regulation Of Intracellular Signal Transduction Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Immunological Synapse Microvillus Organization Regulation Of Mononuclear Cell Proliferation Cell Motility Superoxide-generating NADPH Oxidase Activator Activity Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Intracellular Transport Regulation Of Leukocyte Proliferation Integrin Binding Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Cell Surface Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Lymphocyte Activation	Positive Regulation Of Cellular Component Organization Regulation Of Transport Leukocyte Migration Regulation Of D-glucose Transmembrane Transport Protein Kinase Binding Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Neuromuscular Junction Negative Regulation Of Neuron Differentiation Focal Adhesion Positive Regulation Of Podosome Assembly Regulation Of Podosome Assembly Regulation Of Anatomical Structure Morphogenesis Neuron Projection Morphogenesis Regulation Of Cellular Localization Regulation Of Vesicle-mediated Transport Cell Projection Morphogenesis Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Anoikis Regulation Of Endocytosis Cellular Response To Platelet-derived Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Fc Receptor Mediated Stimulatory Signaling Pathway Response To Platelet-derived Growth Factor Regulation Of Anoikis Integrin Binding Perinuclear Region Of Cytoplasm Ionotropic Glutamate Receptor Binding Negative Regulation Of Inflammatory Response To Antigenic Stimulus Signaling Receptor Binding Establishment Or Maintenance Of Cell Polarity Cellular Response To Fluid Shear Stress Antigen Binding Plasma Membrane Fc-gamma Receptor Signaling Pathway Negative Regulation Of Smoothened Signaling Pathway Cellular Response To Peptide Hormone Stimulus Vesicle Cell Projection Positive Regulation Of Protein Localization Regulation Of Cellular Component Organization Developmental Maturation Positive Regulation Of Transport C5L2 Anaphylatoxin Chemotactic Receptor Binding Positive Regulation Of D-glucose Transmembrane Transport Regulation Of Developmental Process P2Y1 Nucleotide Receptor Binding Adherens Junction
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