HSH2D and TNK2

Number of citations of the paper that reports this interaction (PMID 11700021)
4

Data Source:
HPRD (two hybrid, in vivo)

		HSH2D	TNK2
Gene Name		hematopoietic SH2 domain containing	tyrosine kinase, non-receptor, 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Cytosol	Nucleus Cytoplasm Endosome Plasma Membrane Coated Pit Adherens Junction Membrane Clathrin-coated Vesicle Axon Dendrite Growth Cone Cytoplasmic Vesicle Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Neuronal Cell Body Grb2-EGFR Complex
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity GTPase Inhibitor Activity Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Metal Ion Binding WW Domain Binding Hormone Receptor Binding
	Biological Process	Negative Regulation Of B Cell Apoptotic Process Positive Regulation Of Signal Transduction T Cell Activation Negative Regulation Of Mitochondrial Depolarization	Endocytosis Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Small GTPase Mediated Signal Transduction Phosphorylation Cell Migration Cell Differentiation Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Negative Regulation Of Catalytic Activity Innate Immune Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Clathrin-mediated Endocytosis
Pathways
Drugs			Adenosine triphosphate Debromohymenialdisine
Diseases
GWAS
Protein-Protein Interactions		3 interactors: FES MPP3 TNK2	41 interactors: AQP1 AR ARSE BAG3 CDC42 CLTC CSPG4 CTTN EGFR FYN GALT GRB2 HCK HECW1 HSH2D HSP90AB2P ITFG2 KCNA5 KRTAP10-3 MAGI3 MCF2 MERTK NCK1 NEK6 NOTCH2NL NPHP1 RASGEF1C RASGRF1 RPL18A SEZ6 SH2D1A SIAH1 SMURF1 SNX9 SRC SRSF5 VTI1B WAS WWOX WWP2 YES1
Entrez ID		84941	10188
HPRD ID		12219	06104
Ensembl ID		ENSG00000196684	ENSG00000061938
Uniprot IDs		Q96JZ2	B3KXJ4 C9J1X3 Q07912
PDB IDs		2CS0	1CF4 1U46 1U4D 1U54 3EQP 3EQR 4EWH 4HZR 4HZS 4ID7
Enriched GO Terms of Interacting Partners?		Peptidyl-tyrosine Autophosphorylation Protein Autophosphorylation Peptidyl-tyrosine Phosphorylation Phosphorylation Regulation Of Vesicle-mediated Transport Regulation Of Clathrin-mediated Endocytosis Positive Regulation Of Microtubule Polymerization Phosphate-containing Compound Metabolic Process Positive Regulation Of Actin Cytoskeleton Reorganization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Mast Cell Degranulation Innate Immune Response Regulation Of Microtubule Polymerization Cell Migration Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Regulation Of Mast Cell Activation Peptidyl-amino Acid Modification Regulation Of Regulated Secretory Pathway Regulation Of Actin Cytoskeleton Reorganization Nucleotide Phosphorylation Locomotion Immune Response Protein Phosphorylation Regulation Of Microtubule Polymerization Or Depolymerization Defense Response Positive Regulation Of Myeloid Cell Differentiation	Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Phagocytosis Endocytosis Fc Receptor Signaling Pathway Signaling Positive Regulation Of Signal Transduction Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Differentiation Developmental Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Organization Neuron Development Positive Regulation Of Cellular Component Biogenesis Regulation Of Apoptotic Process Anatomical Structure Development Neuron Projection Development Locomotion Immune Response-regulating Signaling Pathway Cell Migration Regulation Of Cell Death Leukocyte Migration Regulation Of Cellular Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Motility Enzyme Linked Receptor Protein Signaling Pathway Response To Stimulus Neuron Differentiation T Cell Costimulation Cell Projection Organization Neurogenesis Axon Guidance Nervous System Development Vesicle-mediated Transport Positive Regulation Of Protein Complex Assembly Regulation Of Intracellular Signal Transduction Movement Of Cell Or Subcellular Component System Development Positive Regulation Of Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Generation Of Neurons Neuron Projection Morphogenesis Cellular Response To Platelet-derived Growth Factor Stimulus Multicellular Organismal Development Positive Regulation Of Immune Response Negative Regulation Of Signal Transduction
Tagcloud ?			ack1 acquire addiction cdc42 demethylase deprivation deregulated doi explosion facets fuel functionality genotoxic hoxa1 insults jhdm2a kdm3a modifies onc publication reality rtk rtks shuttles soon transduce uncovered unfold wherein
Tagcloud (Difference) ?			ack1 acquire addiction cdc42 demethylase deprivation deregulated doi explosion facets fuel functionality genotoxic hoxa1 insults jhdm2a kdm3a modifies onc publication reality rtk rtks shuttles soon transduce uncovered unfold wherein
Tagcloud (Intersection) ?